Dermal IL-17-producing γδ T cells establish long-lived memory in the skin

Dermal γδ T cells – What have we learned?

(2015) Rebecca L. O’Brien et al.   CELLULAR IMMUNOLOGY

Dermal Vγ4 + γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8 + T-Cell Activity through TNF-α Production

(2015) Satoshi Nakamizo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammation induces dermal Vγ4+γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17–driven responses

(2015) Francisco Ramírez-Valle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldara®-induced skin inflammation: studies of patients with psoriasis

(2014) H. Vinter et al.   BRITISH JOURNAL OF DERMATOLOGY

γδ T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis

(2014) Sarah E. Blink et al.   CELLULAR IMMUNOLOGY

Cutting Edge: An IL-17F-CreEYFP Reporter Mouse Allows Fate Mapping of Th17 Cells

(2014) A. L. Croxford et al.   JOURNAL OF IMMUNOLOGY

Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation

(2014) Yihua Cai et al.   Nature Communications

Gamma delta T cells recognize haptens and mount a hapten-specific response

(2014) Xun Zeng et al.   eLife

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

γδ T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues

(2013) Brian S. Sheridan et al.   IMMUNITY

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

(2013) Melanie Wencker et al.   NATURE IMMUNOLOGY

Langerinneg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice

(2013) C. Wohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldara activates TLR7-independent immune defence

(2013) Anne Walter et al.   Nature Communications

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

IL-23: One cytokine in control of autoimmunity

(2012) Andrew L. Croxford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A canonical Vγ4Vδ4+ γδ T cell population with distinct stimulation requirements which promotes the Th17 response

(2012) Christina L. Roark et al.   IMMUNOLOGIC RESEARCH

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

(2012) Stanislav Pantelyushin et al.   JOURNAL OF CLINICAL INVESTIGATION

Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk

(2012) Luigi Tortola et al.   JOURNAL OF CLINICAL INVESTIGATION

Multieffector-Functional Immune Responses of HMBPP-Specific V 2V 2 T Cells in Nonhuman Primates Inoculated with Listeria monocytogenes  actA prfA*

(2012) B. Ryan-Payseur et al.   JOURNAL OF IMMUNOLOGY

γδ T Cells Augment Rejection of Skin Grafts by Enhancing Cross-Priming of CD8 T Cells to Skin-Derived Antigen

(2012) Azad Rahimpour et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An Alternative Pathway of Imiquimod-Induced Psoriasis-Like Skin Inflammation in the Absence of Interleukin-17 Receptor A Signaling

(2012) Khalifa El Malki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing    cells

(2012) M.-L. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The natural and the inducible: interleukin (IL)-17-producing γδ T cells

(2012) Yueh-hsiu Chien et al.   TRENDS IN IMMUNOLOGY

Psoriasis

(2011) Gayathri K. Perera et al.   Annual Review of Pathology-Mechanisms of Disease

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

(2011) Yihua Cai et al.   IMMUNITY

CD4 T cells play important roles in maintaining IL-17-producing γδ T-cell subsets in naive animals

(2011) Jeong-Su Do et al.   IMMUNOLOGY AND CELL BIOLOGY

Psoriasis and metabolic syndrome

(2011) Hidetoshi TAKAHASHI et al.   JOURNAL OF DERMATOLOGY

Cutaneous immunosurveillance by self-renewing dermal γδ T cells

(2011) Nital Sumaria et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

(2011) A. B. Van Belle et al.   JOURNAL OF IMMUNOLOGY

Identification of a Novel Proinflammatory Human Skin-Homing V 9V 2 T Cell Subset with a Potential Role in Psoriasis

(2011) U. Laggner et al.   JOURNAL OF IMMUNOLOGY

γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism

(2010) Franziska Petermann et al.   IMMUNITY

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

(2010) John S. Cho et al.   JOURNAL OF CLINICAL INVESTIGATION

Treatment Failure of a TLR-7 Agonist Occurs Due to Self-Regulation of Acute Inflammation and Can Be Overcome by IL-10 Blockade

(2010) H. Lu et al.   JOURNAL OF IMMUNOLOGY

Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions

(2010) Batya B. Davidovici et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Economic burden of psoriasis compared to the general population and stratified by disease severity

(2009) Andrew P. Yu et al.   CURRENT MEDICAL RESEARCH AND OPINION

In vivo application of mAb directed against the γδ TCR does not deplete but generates “invisible” γδ T cells

(2009) Christian Koenecke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

(2009) Amit Awasthi et al.   JOURNAL OF IMMUNOLOGY

Expansion, Reexpansion, and Recall-Like Expansion of V 2V 2 T Cells in Smallpox Vaccination and Monkeypox Virus Infection

(2009) L. Shao et al.   JOURNAL OF VIROLOGY

CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

(2009) Julie C Ribot et al.   NATURE IMMUNOLOGY

Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

(2008) Kirk D.C. Jensen et al.   IMMUNITY