Article
Pharmacology & Pharmacy
Agathe Thouvenin, Balthazar Toussaint, Jelena Marinovic, Anne-Laure Gilles, Amelie Dufay Wojcicki, Vincent Boudy
Summary: This study designed a smart formulation of (S)-ketamine for buccal administration to improve absorption by increasing contact with mucosa components. Rheological and mucoadhesion tests were conducted to determine the optimal concentrations and components of the formulation. The study also found that batch-to-batch variability did not have a significant impact on drug release profile. This optimized formulation has fast release and potential clinical value, especially in emergencies.
Review
Pharmacology & Pharmacy
Natalia Veronica, Paul Wan Sia Heng, Celine Valeria Liew
Summary: This review provides an overview of the applications of alginate in solid dosage form formulations, with a focus on its role in oral sustained release formulations. The mechanisms of drug release from alginate matrices, as well as the influence of alginate properties and formulation components on drug release, are discussed. In addition, modifications of alginate to improve its ability to regulate drug release are also explored.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Multidisciplinary Sciences
Santosh Koirala, Prabin Nepal, Govinda Ghimire, Rojina Basnet, Ishwori Rawat, Aashma Dahal, Jitendra Pandey, Kalpana Parajuli-Baral
Summary: The project aimed to formulate and characterize mucoadhesive buccal tablets of aceclofenac using different ratios of three polymers. Twelve batches were prepared and evaluated for physicochemical parameters and in vitro dissolution. The study concluded that buccal mucoadhesive aceclofenac tablets can be successfully formulated with appropriate properties.
Article
Chemistry, Medicinal
Rouheena Shakir, Sana Hanif, Ahmad Salawi, Rabia Arshad, Rai Muhammad Sarfraz, Muhammad Irfan, Syed Atif Raza, Kashif Barkat, Fahad Y. Sabei, Yosif Almoshari, Meshal Alshamrani, Muhammad Ali Syed
Summary: The aim of this study was to develop a buccal delivery system with mucoadhesive properties for sustained release of metformin and sitagliptin in the treatment of diabetes mellitus. The use of Carbopol 940, agarose, and polyvinylpyrrolidone K30 as mucoadhesive agents in tablet formulations resulted in favorable mucoadhesive properties. Formulation R4 showed complete drug release within 6 hours, with a mucoadhesive strength of 26.99 g and a mucoadhesive time of 8.1 h in ex vivo studies. The CP and PVP blend demonstrated stability for up to 6 months. Overall, the CP and PVP blend was found to be appropriate for achieving the desired release and mucoadhesive properties in buccal tablets.
Article
Pharmacology & Pharmacy
Sabrina Barbosa de Souza Ferreira, Giovana Okuda Fukase, Raquel Guttierres Gomes, Marcos Luciano Bruschi
Summary: The development of probiotic formulations for oral health has gained attention, with mucoadhesive wafers being an important system to promote contact between probiotics and oral mucosa. The study aimed to develop wafers containing probiotic microorganisms with suitable mechanical properties for buccal application. The wafers demonstrated good viability and mechanical properties for probiotic use in the oral cavity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Ayesha Mahmood, Asif Mahmood, Mohamed A. Ibrahim, Zahid Hussain, Muhammad Umar Ashraf, Mounir M. Salem-Bekhit, Ibrahim Elbagory
Summary: This research aimed to develop a pH-responsive polymeric system for targeted drug delivery of Diloxanide furoate. Sodium alginate (Na-Alg) and Carbopol 934P were used as building blocks and SCH1-SCH12 were created with different polymer ratios. Positive outcomes were observed in swelling and release profiles at higher pH levels. Hydrogel formation, component compatibility, thermal stability, and Diloxanide furoate loading were all validated. The results showed the potential of this polymeric system for pH-dependent localized and regulated drug delivery.
Article
Biochemistry & Molecular Biology
Ahmed Alzainy, Joshua Boateng
Summary: This research aimed to develop, characterize, and optimize freeze-dried wafers loaded with metronidazole (MTz) to treat vaginal bacterial infections. The study improved the physico-chemical properties of the wafer formulations and successfully achieved sustained drug release and antimicrobial activity, demonstrating potential clinical applications.
Article
Food Science & Technology
Rui Cui, Bifen Zhu, Jiatong Yan, Yuyue Qin, Mingwei Yuan, Guiguang Cheng, Minglong Yuan
Summary: The study prepared antimicrobial food packaging film with controlled release by loading cinnamaldehyde on etched halloysite nanotubes and adding it to sodium alginate matrix. The film showed improved water vapor barrier properties, tensile strength, and reduced negative effects of UV rays. Controlled release of cinnamaldehyde in the film was confirmed, suggesting broad application prospects in fatty food packaging.
Article
Polymer Science
Fhataheya Buang, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. V. Khutoryanskiy
Summary: Non-ionic hydroxyethylcellulose (HEC) was chemically modified with glycidyl methacrylate to enhance its mucoadhesive properties. The modification was confirmed by H-1 NMR and FTIR spectroscopy, and quantification of methacryloyl groups was done using HPLC. Toxicity studies showed no toxicological effects of the modified HEC. Mucoadhesive wafers developed from the modified HEC exhibited significantly better mucoadhesive properties compared to unmodified HEC.
Article
Chemistry, Physical
Aiman Karim, Abdur Rehman, Jianguo Feng, Asia Noreen, Elham Assadpour, Mohammad Saeed Kharazmi, Zhang Lianfu, Seid Mahdi Jafari
Summary: Alginate-based nanocarriers have great potential in the delivery of bioactive compounds. Calcium alginate and sodium alginate, as the most promising wall materials, are non-toxic, relatively cheap, simple to produce, and biocompatible and biodegradable. The review discusses different alginate-based nanocarriers and their entrapment of bioactives, as well as their bioavailability in the gastric environment. Alginate-based nanocarriers can be used as emulsifiers/encapsulants for various bioactives, including vitamins, minerals, peptides, essential oils, and carotenoids. The combination of alginate-based nanocarriers with other polysaccharides/emulsifiers is recognized as the most effective approach for the protection, delivery, and sustained release of bioactives.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Agricultural Engineering
Huazhong Ma, Jianglin Zhao, Ying Liu, Liang Liu, Juan Yu, Yimin Fan
Summary: An interpenetrating network (IPN) hydrogel was developed by crosslinking nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. The nanofibers in the hydrogel greatly extended the release time of aspirin to 60 hours, thanks to the well-structured network. Carboxyl groups played a role in the release capacity in different pH environments. This study provides a guide for the preparation of physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility for drug delivery applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Madhu Tanya Singh, Nunavath Raja Shekhar, Goutham Yerrakula, Senthil Venkatachalam
Summary: The aim of this study is to formulate and evaluate buccal mucoadhesive tablets by a 23 factorial method that can prevent the first-pass metabolism of Diclofenac sodium and increase its bioavailability. Eight different formulations were prepared and evaluated, with formulation F8 showing better properties compared to others.
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
(2023)
Article
Pharmacology & Pharmacy
Napaphak Jaipakdee, Thitiphorn Rongthong, Watchara Kanjanakawinkul, Thaned Pongjanyakul
Summary: Complexation of nicotine with magnesium aluminum silicate was achieved through physical blending. The formed complexes demonstrated potential as drug carriers in buccal matrix formulations due to their sustained release capabilities.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Xiaocheng Wang, Xiaojun Hou, Peiyu Zou, Aimin Huang, Min Zhang, Lin Ma
Summary: This study investigates the controlled release efficacy of nanocomposites based on alginate and bentonite. It was found that (3-chloro-2hydroxypropyl)trimethyl ammonium grafted starch can enhance the swelling property and adsorption capability of the nanocomposites, resulting in a slower release of alachlor.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Raul Diaz-Salmeron, Balthazar Toussaint, Nicolas Huang, Etienne Bourgeois Ducournau, Gabriel Alviset, Sophie Goulay Dufay, Herve Hillaireau, Amelie Dufay Wojcicki, Vincent Boudy
Summary: Oral lichen planus is a chronic inflammatory disease treated with corticosteroid-containing formulations, but this administration route has limitations. The development of a new pharmaceutical formulation with mucoadhesive, sprayable, sustained, and controlled release properties may overcome these limitations for more effective treatment.
Article
Nanoscience & Nanotechnology
Burak Celik, Ali Asram Sagiroglu, Samet Ozdemir
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Review
Pharmacology & Pharmacy
Melike Uner, Sukran Damgali, Samet Ozdemir, Burak Celik
CURRENT PHARMACEUTICAL DESIGN
(2017)
Article
Pharmacology & Pharmacy
Samet Ozdemir, Burak Celik, Ebru Turkoz Acar, Gulengul Duman, Melike Uner
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Samet Ozdemir, Burak Celik, Engin Sumer, Ebru Turkoz Acar, Melike Uner
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Fatma Kazdal, Fatemeh Bahadori, Burak Celik, Abdulselam Ertas, Gulacti Topcu
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Ecem Fatma Karaman, Burak Celik, Samet Ozdemir, Evrim Kepekci Tekkeli, Asli Barla Demirkoz, Umit Gonullu, Melike Uner
Article
Pharmacology & Pharmacy
Ali Asram Sagiroglu, Burak Celik, Eray Metin Guler, Abdurrahim Kocyigit, Ozgen Ozer
Summary: Utilizing response surface methodology, liposomal film formulations containing PTA and CoQ10 were optimized and analyzed for their wound healing efficacy and cytotoxicity on fibroblast and keratinocyte cells. Results indicated that the optimized formulation could be safely used on both cell types and achieved complete wound closure within 24 hours.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zahra Eskandari, Fatemeh Bahadori, Burak Celik, Hayat Onyuksel
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
Burak Celik, Samet Ozdemir, Asli Barla Demirkoz, Melike Uner
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2017)