Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

Unloading of homologous recombination factors is required for restoring double‐stranded DNA at damage repair loci

(2016) Yulia Vasianovich et al.   EMBO JOURNAL

RPA Stabilization of Single-Stranded DNA Is Critical for Break-Induced Replication

(2016) Patrick Ruff et al.   Cell Reports

Role of Double-Strand Break End-Tethering during Gene Conversion in Saccharomyces cerevisiae

(2016) Suvi Jain et al.   PLoS Genetics

Srs2 and Mus81–Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates

(2016) Kenji Keyamura et al.   PLoS Genetics

Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication

(2015) Madhusoodanan Urulangodi et al.   GENES & DEVELOPMENT

Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements

(2015) Cynthia J. Sakofsky et al.   MOLECULAR CELL

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Chromosome rearrangements via template switching between diverged repeated sequences

(2014) Ranjith P. Anand et al.   GENES & DEVELOPMENT

Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability

(2014) Miguel G. Blanco et al.   MOLECULAR CELL

The Cdk/Cdc14 Module Controls Activation of the Yen1 Holliday Junction Resolvase to Promote Genome Stability

(2014) Christie L. Eissler et al.   MOLECULAR CELL

Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms

(2014) Catherine J. Potenski et al.   NATURE

Break-Induced Replication Is a Source of Mutation Clusters Underlying Kataegis

(2014) Cynthia J. Sakofsky et al.   Cell Reports

Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication

(2014) Soumini Vasan et al.   PLoS Genetics

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

(2013) Marenda A. Wilson et al.   NATURE

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Break-induced replication occurs by conservative DNA synthesis

(2013) R. A. Donnianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes

(2013) Katrina Mitchel et al.   PLoS Genetics

Unwinding of synthetic replication and recombination substrates by Srs2

(2012) Victoria Marini et al.   DNA REPAIR

Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

(2011) Erin K. Schwartz et al.   CHROMOSOMA

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin

(2011) ManTek Yeung et al.   DNA REPAIR

Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

(2011) Jie Liu et al.   NATURE

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly

(2010) J. R. Lydeard et al.   GENES & DEVELOPMENT

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

(2010) Woo-Hyun Chung et al.   PLoS Genetics

Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo

(2009) Rebecca C. Burgess et al.   JOURNAL OF CELL BIOLOGY

Aberrant Double-Strand Break Repair Resulting in Half Crossovers in Mutants Defective for Rad51 or the DNA Polymerase   Complex

(2009) C. E. Smith et al.   MOLECULAR AND CELLULAR BIOLOGY

SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

(2009) Alix Kerrest et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption

(2009) S. Colavito et al.   NUCLEIC ACIDS RESEARCH

Defective Break-Induced Replication Leads to Half-Crossovers in Saccharomyces cerevisiae

(2008) A. Deem et al.   GENETICS

The Srs2 Helicase Activity Is Stimulated by Rad51 Filaments on dsDNA: Implications for Crossover Incidence during Mitotic Recombination

(2008) Pauline Dupaigne et al.   MOLECULAR CELL

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA

(2008) C. Le Breton et al.   NUCLEIC ACIDS RESEARCH