CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

Is TMC1 the Hair Cell Mechanotransducer Channel?

(2016) Robert Fettiplace   BIOPHYSICAL JOURNAL

Molecular Identity of the Mechanotransduction Channel in Hair Cells: Not Quiet There Yet

(2016) Z. Wu et al.   JOURNAL OF NEUROSCIENCE

Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

(2016) D. P. Corey et al.   JOURNAL OF NEUROSCIENCE

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

(2016) Zizhen Wu et al.   NATURE NEUROSCIENCE

Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells

(2016) Maryline Beurg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells

(2015) Celia Zazo Seco et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family

(2015) Kunjan Patel et al.   PLoS One

Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear

(2015) Meghan C. Drummond et al.   Nature Communications

SHIELD: an integrative gene expression database for inner ear research

(2015) Jun Shen et al.   Database-The Journal of Biological Databases and Curation

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

(2015) Kiyoto Kurima et al.   Cell Reports

The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

(2015) Qing Fang et al.   eLife

Transduction without Tip Links in Cochlear Hair Cells Is Mediated by Ion Channels with Permeation Properties Distinct from Those of the Mechano-Electrical Transducer Channel

(2014) W. Marcotti et al.   JOURNAL OF NEUROSCIENCE

TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells

(2014) Bo Zhao et al.   NEURON

Subunit determination of the conductance of hair-cell mechanotransducer channels

(2014) Maryline Beurg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

(2014) R. Maeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels

(2013) Kyunghee X. Kim et al.   JOURNAL OF GENERAL PHYSIOLOGY

TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear

(2013) Bifeng Pan et al.   NEURON

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2

(2013) David N. Furness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells

(2012) Wei Xiong et al.   CELL

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

(2012) Steve D. M. Brown et al.   MAMMALIAN GENOME

Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia

(2012) Duan-Sun Zhang et al.   NATURE

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48

(2012) Saima Riazuddin et al.   NATURE GENETICS

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

(2011) Yoshiyuki Kawashima et al.   JOURNAL OF CLINICAL INVESTIGATION

Actin-Bundling Protein TRIOBP Forms Resilient Rootlets of Hair Cell Stereocilia Essential for Hearing

(2010) Shin-ichiro Kitajiri et al.   CELL

Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression

(2010) Meghna U. Naik et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CIB1 is a regulator of pathological cardiac hypertrophy

(2010) Joerg Heineke et al.   NATURE MEDICINE

Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling

(2009) Magdalena Blazejczyk et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast Adaptation and Ca2+ Sensitivity of the Mechanotransducer Require Myosin-XVa in Inner But Not Outer Cochlear Hair Cells

(2009) R. Stepanyan et al.   JOURNAL OF NEUROSCIENCE

CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3

(2009) M. U. NAIK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE