Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

Differential requirement forde novolipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans

(2016) Lei Li et al.   HEPATOLOGY

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

(2016) Lei Li et al.   JOURNAL OF HEPATOLOGY

Bothde novosynthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells

(2016) Dan Cao et al.   LIVER INTERNATIONAL

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Dietary sugar intake increases liver tumor incidence in female mice

(2016) Marin E. Healy et al.   Scientific Reports

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

(2016) Junjie Hu et al.   Scientific Reports

Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life

(2015) Susan C. Modesitt et al.   GYNECOLOGIC ONCOLOGY

Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine

(2015) Marin E. Healy et al.   JOURNAL OF HEPATOLOGY

Metabolic Vulnerabilities in Endometrial Cancer

(2014) F. L. Byrne et al.   CANCER RESEARCH

SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma

(2014) Chao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

(2014) Jenny D.Y. Chow et al.   Molecular Metabolism

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

(2013) Nousheen Zaidi et al.   PROGRESS IN LIPID RESEARCH

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

(2013) Brandon M. Kenwood et al.   Molecular Metabolism

FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma

(2012) Tokuzo Arao et al.   HEPATOLOGY

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

De-novo-Lipogenese

(2011) D.F. Calvisi   PATHOLOGE

A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients

(2010) S. Roessler et al.   CANCER RESEARCH

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatocellular Carcinoma: Consensus Recommendations of the National Cancer Institute Clinical Trials Planning Meeting

(2010) Melanie B. Thomas et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma

(2009) Giuseppe Cabibbo et al.   HEPATOLOGY

Experimental mouse models for hepatocellular carcinoma research

(2009) Femke Heindryckx et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma

(2008) Taro Yamashita et al.   JOURNAL OF HEPATOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE