SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

Deletion of the DistalTnfsf11RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice

(2016) Melda Onal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes

(2016) Henry Huang et al.   PLoS One

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

(2015) Jianwen Wei et al.   CELL

DLC1-dependent parathyroid hormone–like hormone inhibition suppresses breast cancer bone metastasis

(2014) Yufeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

(2014) Janet L. Crane et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

(2014) Christopher S. Kovacs   PHYSIOLOGICAL REVIEWS

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Vitamin D Receptor in Osteoblasts Is a Negative Regulator of Bone Mass Control

(2013) Yoko Yamamoto et al.   ENDOCRINOLOGY

A nonclassical vitamin D receptor pathway suppresses renal fibrosis

(2013) Ichiaki Ito et al.   JOURNAL OF CLINICAL INVESTIGATION

The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2

(2013) Weiguo Zou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gastric Acid, Calcium Absorption, and Their Impact on Bone Health

(2013) Sascha Kopic et al.   PHYSIOLOGICAL REVIEWS

Molecular Mechanisms of Vitamin D Action

(2012) Mark R. Haussler et al.   CALCIFIED TISSUE INTERNATIONAL

Smurf2 Regulates the Senescence Response and Suppresses Tumorigenesis in Mice

(2012) C. Ramkumar et al.   CANCER RESEARCH

Molecular Mechanisms in Coupling of Bone Formation to Resorption

(2012) T. John Martin et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43

(2012) Tone Aase Fykerud et al.   JOURNAL OF CELL SCIENCE

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of bone resorption in mice by Schnurri-3

(2012) M. N. Wein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

(2011) Liu-Ya Tang et al.   EMBO JOURNAL

The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein

(2011) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice

(2011) Weiguo Zou et al.   JOURNAL OF CLINICAL INVESTIGATION

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development

(2011) Pei-lin Cheng et al.   NEURON

TGF-β in cancer and bone: Implications for treatment of bone metastases

(2010) Patricia Juárez et al.   BONE

Extracellular Microfibrils Control Osteoblast-supported Osteoclastogenesis by Restricting TGFβ Stimulation of RANKL Production

(2010) Harikiran Nistala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

(2010) Matthew B. Greenblatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

Smurf2 induces degradation of GSK-3β and upregulates β-catenin in chondrocytes: A potential mechanism for Smurf2-induced degeneration of articular cartilage

(2009) Qiuqian Wu et al.   EXPERIMENTAL CELL RESEARCH

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice

(2008) Qiuqian Wu et al.   ARTHRITIS AND RHEUMATISM

Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression

(2008) Kinglun Kingston Mak et al.   DEVELOPMENTAL CELL

Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

(2008) Roger Bouillon et al.   ENDOCRINE REVIEWS

Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-κB Ligand Gene Reduces Bone Remodeling and Increases Bone Mass

(2007) Carlo Galli et al.   ENDOCRINOLOGY