Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

Ixazomib: First Global Approval

(2016) Matt Shirley   DRUGS

The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression

(2016) Leah Randles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting proteasome ubiquitin receptor Rpn13 in multiple myeloma

(2016) Y Song et al.   LEUKEMIA

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome

(2016) Xiang Chen et al.   STRUCTURE

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ADRM1-amplified metastasis gene in gastric cancer

(2015) Marlena S. Fejzo et al.   GENES CHROMOSOMES & CANCER

Synthesis, Characterization, and Optimization for in Vivo Delivery of a Nonselective Isopeptidase Inhibitor as New Antineoplastic Agent

(2015) Ulma Cersosimo et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Reversible and Highly Selective Inhibitor of the Proteasomal Ubiquitin Receptor Rpn13 Is Toxic to Multiple Myeloma Cells

(2015) Darci J. Trader et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Plasticity Allows UCH37 to Be Primed by RPN13 or Locked Down by INO80G

(2015) Xiang Chen et al.   MOLECULAR CELL

Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

(2015) Danny D. Sahtoe et al.   MOLECULAR CELL

Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase

(2015) Ryan T. VanderLinden et al.   MOLECULAR CELL

A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells

(2015) Xiuxiu Lu et al.   PLoS One

ADRM1 gene amplification is a candidate driver for metastatic gastric cancers

(2014) Seok Hoon Jang et al.   CLINICAL & EXPERIMENTAL METASTASIS

The Intrinsically Disordered Sem1 Protein Functions as a Molecular Tether during Proteasome Lid Biogenesis

(2014) Robert J. Tomko et al.   MOLECULAR CELL

Dss1 Is a 26S Proteasome Ubiquitin Receptor

(2014) Konstantinos Paraskevopoulos et al.   MOLECULAR CELL

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

(2014) P. Unverdorben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer

(2014) Lin Wang et al.   TUMOR BIOLOGY

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Mechanism of the Rpn13-induced activation of Uch37

(2014) Lianying Jiao et al.   Protein & Cell

Structural Insights into Proteasome Activation by the 19S Regulatory Particle

(2013) Aaron Ehlinger et al.   BIOCHEMISTRY

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

(2013) Ravi K. Anchoori et al.   CANCER CELL

U.S. Food and Drug Administration Approval: Carfilzomib for the Treatment of Multiple Myeloma

(2013) T. M. Herndon et al.   CLINICAL CANCER RESEARCH

Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer

(2013) Marlena Fejzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19

(2012) Ying Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma

(2012) Yanjie Chen et al.   DIGESTIVE DISEASES AND SCIENCES

Rpn1 and Rpn2 Coordinate Ubiquitin Processing Factors at Proteasome

(2012) Rina Rosenzweig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy

(2012) E. Sakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings

(2012) Jun He et al.   STRUCTURE

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Structural characterization of human Uch37

(2011) Sethe E. Burgie et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Early phase TGFβ receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses

(2010) Anthony J. Cutts et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2

(2010) Xiang Chen et al.   MOLECULAR CELL

Multitasking with ubiquitin through multivalent interactions

(2010) Fen Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Together, Rpn10 and Dsk2 Can Serve as a Polyubiquitin Chain-Length Sensor

(2009) Daoning Zhang et al.   MOLECULAR CELL

Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13

(2009) Naixia Zhang et al.   MOLECULAR CELL

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

(2009) A Arlt et al.   ONCOGENE

Neutralization of complement regulatory proteins CD55 and CD59 augments therapeutic effect of herceptin against lung carcinoma cells

(2009) Chen   ONCOLOGY REPORTS

Comprehensive analysis of 20q13 genes in ovarian cancer identifiesADRM1as amplification target

(2008) Marlena S. Fejzo et al.   GENES CHROMOSOMES & CANCER

Distinct Modes of Regulation of the Uch37 Deubiquitinating Enzyme in the Proteasome and in the Ino80 Chromatin-Remodeling Complex

(2008) Tingting Yao et al.   MOLECULAR CELL

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

(2008) Patrick Schreiner et al.   NATURE

Proteasome subunit Rpn13 is a novel ubiquitin receptor

(2008) Koraljka Husnjak et al.   NATURE

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities

(2008) Benjamin Nicholson et al.   PROTEIN SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome

(2007) Elena Koulich et al.   MOLECULAR BIOLOGY OF THE CELL