The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

(2016) S. C. Melkonian et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

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WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenylm-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site

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Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

(2016) Emma M. Kerr et al.   NATURE

Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers

(2016) Guoli Chen et al.   Translational Cancer Research

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

(2015) Fuming Li et al.   CANCER CELL

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers

(2015) M. Momcilovic et al.   CANCER RESEARCH

Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes

(2015) M. Robertson-Tessi et al.   CANCER RESEARCH

Safety and Efficacy of Buparlisib (BKM120) in Patients with PI3K Pathway-Activated Non-Small Cell Lung Cancer

(2015) Johan F. Vansteenkiste et al.   Journal of Thoracic Oncology

Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial

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(2015) Gina M DeNicola et al.   NATURE GENETICS

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Is the Glut expression related to FDG uptake in PET/CT of non-small cell lung cancer patients?

(2015) Woo Hee Choi et al.   TECHNOLOGY AND HEALTH CARE

Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression

(2014) Chunxiao Xu et al.   CANCER CELL

Glucose Metabolism in NSCLC Is Histology-Specific and Diverges the Prognostic Potential of 18FDG-PET for Adenocarcinoma and Squamous Cell Carcinoma

(2014) Olga C.J. Schuurbiers et al.   Journal of Thoracic Oncology

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1 

(2014) B. Faubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

The pentose phosphate pathway and cancer

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LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Spheroid Culture of Primary Lung Cancer Cells with Neuregulin 1/HER3 Pathway Activation

(2013) Hiroko Endo et al.   Journal of Thoracic Oncology

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(2013) John N Weinstein et al.   NATURE GENETICS

TCPA: a resource for cancer functional proteomics data

(2013) Jun Li et al.   NATURE METHODS

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Glucose transporters in cancer metabolism

(2012) Kehinde Adekola et al.   CURRENT OPINION IN ONCOLOGY

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(2012) C. V. Dang   GENES & DEVELOPMENT

Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy

(2012) Alexander Drilon et al.   LANCET ONCOLOGY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

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Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Histological Subtypes of Lung Adenocarcinoma Have Differential 18F-Fluorodeoxyglucose Uptakes on the Positron Emission Tomography/Computed Tomography Scan

(2011) Chao-Hua Chiu et al.   Journal of Thoracic Oncology

Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: Spatial distribution and prognostic value of GLUT1 and MCT4

(2011) Tineke W.H. Meijer et al.   LUNG CANCER

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

(2011) V. S. Rodrik-Outmezguine et al.   Cancer Discovery

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Metabolism strikes back: metabolic flux regulates cell signaling

(2010) C. M. Metallo et al.   GENES & DEVELOPMENT

Lung Cancer Cell Lines as Tools for Biomedical Discovery and Research

(2010) Adi F. Gazdar et al.   JNCI-Journal of the National Cancer Institute

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

PIK3CA Mutations and Copy Number Gains in Human Lung Cancers

(2008) H. Yamamoto et al.   CANCER RESEARCH

First-Line Chemotherapy for Non–Small-Cell Lung Cancer: Is There a Superior Regimen Based on Histology?

(2008) Lawrence H. Einhorn   JOURNAL OF CLINICAL ONCOLOGY

Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis: A Korean Lung Cancer Registry Study

(2008) Kwang-Ho In et al.   LUNG CANCER