Article
Oncology
Mee Joo Kang, Jiwon Lim, Sung-Sik Han, Hyeong Min Park, Sang-Jae Park, Young-Joo Won, Sun-Whe Kim
Summary: This study investigated the trends in initial treatment and corresponding prognosis of patients with exocrine pancreatic cancer (EPC) in Korea. The findings showed that less than half of the patients with localized EPC underwent surgical treatment, and this proportion decreased significantly in elderly patients. Surgical treatment led to higher 5-year relative survival rates compared to no active treatment for localized EPC. Therefore, clinicians should pay attention to elderly patients with EPC and provide appropriate medical advice.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Eileen Morgan, Melina Arnold, Mark J. Rutherford, Aude Bardot, Jacques Ferlay, Prithwish De, Gerda Engholm, Christopher Jackson, Alana Little, Nathalie Saint-Jacques, Paul Walsh, Ryan R. Woods, Dianne L. O'Connell, Freddie Bray, D. Max Parkin, Isabelle Soerjomataram
Summary: Research has shown variations in lung cancer survival rates among different countries, partially attributable to differences in the distribution of unspecified histology cases. International differences in SCLC and NSCLC survival rates are only partially attributable to differences in the distribution of unspecified histology, with other factors such as underlying risk factors, stage, comorbidity, and care management also playing significant roles.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Sang Yull Kang, Sae Byul Lee, Yoo Seok Kim, Zisun Kim, Hyun Yul Kim, Hee Jeong Kim, Sungmin Park, Soo Youn Bae, Kwanghyun Yoon, Se Kyung Lee, Kyu Won Jung, Jaihong Han, Hyun Jo Youn
Summary: Breast cancer is the most common malignancy in Korean women, and its incidence continues to increase. The clinical characteristics of breast cancer in Korea have been changing over time, with a significant increase in the 5-year relative survival rate of patients from 2014 to 2018 compared to 1993 to 1995. Additionally, there has been a shift towards more breast-conserving surgery and an increase in the proportion of patients with early-stage breast cancer.
JOURNAL OF BREAST CANCER
(2021)
Article
Oncology
Allini Mafra, Mathieu Laversanne, Mary Gospodarowicz, Paulo Klinger, Neimar De Paula Silva, Marion Pineros, Eva Steliarova-Foucher, Freddie Bray, Ariana Znaor
Summary: Global patterns of non-Hodgkin lymphoma (NHL) in 2020 were evaluated using the GLOBOCAN 2020 database. The study found that Eastern Asia, Northern America, and South-Central Asia had the highest number of NHL cases. Incidence rates were higher in men than in women, with the highest rates in Australia, New Zealand, Northern America, Northern Europe, and Western Europe. The highest mortality rates were found in regions in Africa, Western Asia, and Oceania.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Ho Kang, Sang Woo Song, Johyun Ha, Young-Joo Won, Chul-Kee Park, Heon Yoo, Kyu-Won Jung
Summary: In Korea, malignant brain and other CNS tumors have a lower incidence and better survival outcome compared to the United States. Meningeal tumors are the most common histologic group among all tumors, and the 5-year survival rate of all malignant tumors is higher than that observed in the United States.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Ana Paula de Souza Franco, Eric Renato Lima Figueiredo, Giovana Salomao Melo, Josiel de Souza e Souza, Nelson Veiga Goncalves, Fabiana de Campos Gomes, Joao Simao de Melo Neto
Summary: This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic and treatment procedures on reducing mortality. The retrospective ecological study analyzed mortality data from testicular cancer in Brazil from 2001 to 2020. Data revealed an increasing trend in mortality after 2011 among persons born after 1976 in the 15-40 age group.
Article
Oncology
Jung Eun Choi, Zisun Kim, Chan Sub Park, Eun Hwa Park, Sae Byul Lee, Se Kyung Lee, Young Jin Choi, Jaihong Han, Kyu-Won Jung, Hee Jeong Kim, Hyun-Ah Kim
Summary: This article presents the latest statistics on breast cancer in South Korea, including incidence, tumor stage, treatment options, and mortality. The data was collected from reliable registries. It reveals that breast cancer has been on the rise since 2002 and has become the most common cancer in Korean women since 2019. The report also highlights an increase in early-stage cases and improved survival rates.
JOURNAL OF BREAST CANCER
(2023)
Article
Oncology
Rithva Rahman, Jonas F. Ludvigsson, Erik von Seth, Jesper Lagergren, Annika Bergquist, Cecilia Radkiewicz
Summary: The incidence of intrahepatic and perihilar cholangiocarcinoma is increasing in Sweden, especially among younger adults, while the incidence of gallbladder cancer is decreasing.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Kyuwoong Kim, Bohyun Park, Bonju Gu, Eun Jeong Nam, Sue Hyun Kye, Jin Young Choi
Summary: The National Hospice and Palliative Care (NHPC) registry is a nationwide database in Korea that collects information on terminally ill cancer patients receiving inpatient hospice care. The database contains socio-demographic and clinical information of the registered patients. The majority of the patients were 60 years or older, with a male-to-female ratio of 1:1.41. The most common cancer sites among the registered patients were lung, liver, colorectal, pancreatic, and gastric cancer. Around 80% of the patients were aware of their terminal illness upon admission to the hospice ward. The duration of hospice care was 14 days in 2019 and 2020.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Oncology
Mariana Brandao, Diogo Martins-Branco, Claudia De Angelis, Peter Vuylsteke, Richard D. Gelber, Nancy Van Damme, Lien van Walle, Arlindo R. Ferreira, Matteo Lambertini, Francesca Poggio, Didier Verhoeven, Annelore Barbeaux, Francois P. Duhoux, Hans Wildiers, Carmela Caballero, Ahmad Awada, Martine Piccart-Gebhart, Kevin Punie, Evandro de Azambuja
Summary: Among patients with de novo metastatic breast cancer who received systemic treatment and survived for nine months or more, those who underwent surgery of the primary tumor within nine months of diagnosis had longer overall survival compared to those who did not.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Respiratory System
Kerri A. Johannson, Brendan C. Lethebe, Deborah Assayag, Jolene H. Fisher, Martin Kolb, Julie Morisset, Shane Shapera, Andrea S. Gershon, Nathan Hambly, Nasreen Khalil, Teresa To, Charlene D. Fell, Gerard Cox, Helene Manganas, Andrew J. Halayko, Veronica Marcoux, Mohsen Sadatsafavi, Pearce G. Wilcox, Stefania Bertazzon, Christopher J. Ryerson
Summary: Patients with fibrotic interstitial lung disease who live farther away from their clinic have more severe disease at time of referral and worse clinical outcomes, particularly among those with connective tissue disease-related ILD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Oncology
Camila Macedo Lima Nagamine, Barbara Niegia Garcia de Goulart, Patricia Klarmann Ziegelmann
Summary: This scoping review examines the use and justifications of the Pohar Perme Estimator (PPE) in estimating net survival in oncology. The review finds that PPE is recognized as the gold standard for estimating net survival and is valued for its unbiased estimates and comparability among different populations. No limitations of using PPE are identified. The review concludes that PPE should be more widely used in oncology, especially for population-based studies with long follow-up time.
Article
Oncology
Tayna Sequeira Valerio, Isabel Cristina Martins Emmerick, Mario Jorge Sobreira-da-Silva
Summary: This study compares the factors associated with late-stage diagnosis and overall survival rates of lung cancer in Brazilian and US hospitals. Late-stage diagnosis was found to be the most significant factor influencing overall survival in both cohorts, but the factors related to late-stage diagnosis differed between Brazil and the US. The study provides important insights into inequities and barriers to access for lung cancer patients in upper-middle-income and high-income countries.
CANCER EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Chunhe Yao, Jean-Michel Billette
Summary: The study presents detailed tumour-based cancer prevalence estimates in Canada, showing that cancer prevalence increases significantly with age, especially among those aged 60 and older. The four most prevalent cancers (breast, prostate, colorectal, lung) accounted for 49.6% of total five-year cancer prevalence in Canada.
Article
Oncology
Ida Wiken, Therese M-L Andersson, Cecilia Radkiewicz
Summary: This study investigates the impact of holidays on cancer incidence and survival rates in Sweden. It finds that cancer cases decline during holidays and increase post-holidays for certain types of cancer. The study also reveals higher mortality rates for cancers diagnosed during holidays, emphasizing the need for consistent cancer care throughout the year.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung Wan Kang, Won Gi Jeong, Jong Eun Lee, In-Jae Oh, Sang Yun Song, Byung Chan Lee, Yun-Hyeon Kim
Summary: This study aimed to determine the prognostic significance of central lung cancer in resected T1-sized early-stage non-small cell lung cancer (NSCLC). The results showed that central lung cancer, defined by a location index, was adversely associated with relapse-free survival and overall survival. It was found to be an independent adverse prognostic factor in early-stage NSCLC.
Article
Allergy
Seong Mi Moon, Hayoung Choi, Hyung Koo Kang, Sei Won Lee, Yun Su Sim, Hye Yun Park, Yong-Soo Kwon, Sang-Heon Kim, Yeon-Mok Oh, Hyun Lee
Summary: This study evaluated 598 patients from the Korean Bronchiectasis Registry and found that bronchiectasis patients with asthma had higher BMI, more dyspnea, larger sputum volume, and lower FEV1 than those without asthma. Asthma was also associated with lower quality of life. Therefore, understanding the impacts of asthma in bronchiectasis is crucial for appropriate management.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jieun Kang, Man Pyo Chung, Moo Suk Park, In Jae Oh, Heung Bum Lee, Young Whan Kim, Jong Sun Park, Soo Taek Uh, Yun Seong Kim, Yangjin Jegal, Jin Woo Song
Summary: This study evaluated the impact of reduced dose of pirfenidone on clinical outcomes in patients with IPF. The results showed that reduced doses did not have a negative impact on clinical outcomes compared to standard-dose pirfenidone, suggesting that dose reduction may be a useful method to manage adverse events while maintaining therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Cheol-Kyu Park, Nakyung Jeon, Hwa-Kyung Park, Hyung-Joo Oh, Young-Chul Kim, Ha-Lim Jeon, Yong-Hyub Kim, Sung-Ja Ahn, In-Jae Oh
Summary: In this retrospective cohort study, durvalumab consolidation (DC) after concurrent chemoradiotherapy (CCRT) was found to be associated with survival benefits in real-world contexts, supporting its establishment as a new standard of care for stage III NSCLC. The study aimed to provide real-world evidence regarding the effectiveness and safety of DC after CCRT in the treatment of unresectable stage III NSCLC.
Article
Oncology
Gowoon Yang, Chang Young Lee, Eun Young Kim, Chang Geol Lee, Min Hee Hong, Byung Jo Park, Hong In Yoon, Kyung Hwan Kim, Sang Hoon Lee, Hwa Kyung Byun, Jaeho Cho
Summary: This study aimed to determine the role of radiotherapy (RT) and the optimal RT target volume in the treatment of thymic carcinoma. A total of 116 patients who received multimodal treatment were included. The target volume was defined as the tumor bed or gross tumor with margin, and selective irradiation of the regional nodal area was performed when involved. The results showed a high local control rate with RT, and a target volume confined to the tumor bed or gross tumor plus margin with the involved lymph node stations seems reasonable.
Article
Oncology
Cheol-Kyu Park, Sung-Woo Lee, Hyun-Ju Cho, Hyung-Joo Oh, Young-Chul Kim, Yong-Hyub Kim, Sung-Ja Ahn, Jae-Ho Cho, In-Jae Oh
Summary: A total of 50 patients with unresectable stage III NSCLC who received CCRT between March 2020 and March 2021 were recruited. Durvalumab consolidation (DC) was administered to patients (n=23) without progression after CCRT and programmed death-ligand 1 (PD-L1) ≥1%. Blood samples collected before (C0) and after CCRT (C1) were analyzed to calculate PBC counts and examine CTCs. The study found that the presence of residual CTC clusters at C1 and high platelet counts at C1 (PLThi) were independent risk factors for worse progression-free survival (PFS). The study suggests that the clearance of CTC clusters and platelet counts at C1 could serve as potential biomarkers for predicting survival.
Article
Cell Biology
Cheol-Kyu Park, Ha Ra Jun, Hyung-Joo Oh, Ji-Young Lee, Hyun-Ju Cho, Young-Chul Kim, Jeong Eun Lee, Seong Hoon Yoon, Chang Min Choi, Jae Cheol Lee, Sung Yong Lee, Shin Yup Lee, Sung-Min Chun, In-Jae Oh
Summary: This study aimed to investigate the feasibility of blood-based biomarkers, including blood tumor mutation burden (bTMB), to predict atezolizumab efficacy in relapsed and advanced non-small cell lung cancer (NSCLC). The results suggest that baseline levels and dynamic changes of blood-based biomarkers can predict atezolizumab efficacy in previously treated NSCLC patients.
Article
Oncology
Ha-Young Park, Joo-Heon Park, Myung-Geun Shin, Seung Jung Han, Yong-Sok Ji, Hyung-Joo Oh, Young-Chul Kim, Taebum Lee, Yoo-Duk Choi, In-Jae Oh
Summary: This case report presents a rare case of ultra-late recurrence of NSCLC with choroidal metastasis and KIF13A-RET fusion in a 48-year-old female never-smoker. The patient had undergone lobectomy followed by adjuvant chemotherapy 14 years prior. Choroidal metastatic lesions were observed, along with bone and uterine metastases. Liquid-based NGS confirmed the presence of KIF13A-RET fusion, and the patient showed a partial response to selpercatinib therapy.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Oncology
Cheol-Kyu Park, In-Jae Oh, Young-Chul Kim
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
David Hong, Sang Min Kim, Sang Yeub Lee, Ki Hong Choi, Young Bin Song, Jong-Young Lee, Seung-Jae Lee, Kyeong Ho Yun, Jae Young Cho, Chan Joon Kim, Hyo-Suk Ahn, Chang-Wook Nam, Hyuck-Jun Yoon, Yong Hwan Park, Wang Soo Lee, Jin-Ok Jeong, Pil Sang Song, Joon-Hyung Doh, Sang-Ho Jo, Chang-Hwan Yoon, Min Gyu Kang, Jin-Sin Koh, Kwan Yong Lee, Young-Hyo Lim, Yun-Hyeong Cho, Jin-Man Cho, Woo Jin Jang, Kook-Jin Chun, Taek Kyu Park, Jeong Hoon Yang, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, Joo Myung Lee
Article
Cardiac & Cardiovascular Systems
Seung Hun Lee, David Hong, Doosup Shin, Hyun Kuk Kim, Keun Ho Park, Eun Ho Choo, Chan Joon Kim, Min Chul Kim, Young Joon Hong, Sung Gyun Ahn, Joon-Hyung Doh, Sang Yeub Lee, Sang Don, Hyun-Jong Lee, Min Gyu Kang, Jin-Sin Koh, Yun-Kyeong Cho, Chang-Wook Nam, Hyun Sung Joh, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Myung Ho Jeong, Hyeon-Cheol Gwon, Joo-Yong Hahn, Joo Myung Lee
Summary: In AMI patients with multivessel disease, 30.0% of angiography-guided PCI resulted in un-necessary PCI for the non-IRA with QFR >0.80, which was significantly associated with an increased risk of MACEs than in those with deferred PCI for non-IRA lesions.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Oncology
In-Jae Oh, Cheol-Kyu Park, Kyoung-Bok Min, Jin-Young Min, Chaeuk Chung, Seong-Hoon Yoon, Changsoo Kim, Sei-Hoon Yang
Summary: A study in Korea found that lung cancer patients exposed to high concentrations of PM2.5 had significantly increased healthcare utilization and drug prescriptions.
Article
Medicine, General & Internal
Min-Gwan Sun, Sue Jee Park, Yeong Jin Kim, Kyung-Sub Moon, In-Young Kim, Shin Jung, Hyung-Joo Oh, In-Jae Oh, Tae-Young Jung
Summary: There is ongoing controversy regarding whether to use radiologic follow-up or local treatment for asymptomatic small-sized brain metastases from primary lung cancer. This study evaluated the potential factors related to brain progression and the effectiveness of systemic therapy in controlling tumors without local treatment. The results showed that targeted therapy was superior to cytotoxic chemotherapy in the treatment of these brain metastases, offering the opportunity to determine the optimal timing for local treatment while reducing the risk of brain-related mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Hwa Kyung Park, Yoo Duk Choi, Ju-Sik Yun, Sang-Yun Song, Kook-Joo Na, Joon Young Yoon, Chang-Seok Yoon, Hyung-Joo Oh, Young-Chul Kim, In-Jae Oh
Summary: This study investigated the prevalence of genetic alterations in early-stage non-small cell lung cancer (NSCLC) and the association between EGFR mutations and recurrence after surgical resection. The presence of EGFR mutations was found to be an independent risk factor for recurrence and was associated with systemic recurrence. Targeted therapy should be considered more actively as an adjuvant or neoadjuvant treatment option.
Article
Oncology
Wonjun Ji, In-Jae Oh, Cheol-Kyu Park, Sung Yong Lee, Juwhan Choi, Jae Cheol Lee, Jiwon Kim, Seung Hyeun Lee
Summary: This study provides real-world evidence of the effectiveness and safety of afatinib as a treatment option for patients with squamous cell carcinoma of the lung (LSCC) who have progressed after chemotherapy and immunotherapy. The study also highlights the potential predictive value of the ERBB2 mutation as a biomarker in clinical settings.