Article
Medicine, General & Internal
Zhuangkai Liu, Hong Xu, Xiang Li, Ruishan Zhang, Jinghui Bai, Xinfeng Zhang
Summary: Recent studies have identified the potential therapeutic role of miR-325-3p in breast cancer. The expression of miR-325 was found to be significantly suppressed in breast cancer tissues and cell lines. Ectopic expression of miR-325 inhibited cell growth and colony formation in breast cancer cells.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Oncology
Xuesong Deng, Jun Cheng, Naiyang Zhan, Jianwei Chen, Yongqiang Zhan, Yong Ni, Caixian Liao
Summary: This study found that TONSL-AS1 expression is downregulated in hepatocellular carcinoma tissues, associated with lower survival rates. There is an interaction between miR-135a and TONSL-AS1, where overexpression of miR-135a decreases TONSL-AS1 expression. Overexpression of TONSL-AS1 inhibits HCC cell proliferation, while overexpression of miR-135a promotes cell proliferation.
Review
Oncology
Upendra K. Soni, Liam Jenny, Rashmi S. Hegde
Summary: The insulin-like growth factor receptor (IGF-1R) has been extensively studied as a potential target in oncology, but the initial promise has not been fulfilled due to resistance mechanisms and toxicities. Lack of patient stratification based on biomarkers in previous clinical trials has been recognized as a limitation. There is now growing interest in revisiting IGF-1R targeted therapeutics with predictive biomarker-driven patient stratification. The sub-cellular localization of IGF-1R has emerged as a potential biomarker.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Maria Dobre, Vlad Herlea, Catalina Vladut, Mihai Ciocirlan, Vasile Daniel Balaban, Gabriel Constantinescu, Mircea Diculescu, Elena Milanesi
Summary: The study identified a panel of downregulated miRNAs in PDAC tissue, which could serve as potential therapeutic targets for the development of new miRNA-based therapies for PDAC.
Article
Oncology
Neng Tang, Xiaolin Dou, Xing You, Yixiong Li, Xi Li, Guodong Liu
Summary: The study revealed that androgen receptor can suppress HCC cells invasion and migration capacities via miR-122-5p/RABL6 signaling, providing a new potential therapeutic target for better treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Xia-Hui Lin, Dan-Ying Zhang, Zhi-Yong Liu, Wen-qing Tang, Rong-Xin Chen, Dong-ping Li, Shuqiang Weng, Ling Dong
Summary: The lncRNA-AC079061.1/VIPR1 axis was identified as a novel biomarker that inhibited the proliferation and invasion of hepatocellular carcinoma, affecting the ultimate disease outcome.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yinqi Zhang, Chengqi Gao, Fei Cao, Ying Wu, Shuanggang Chen, Xue Han, Jingqin Mo, Zhiyu Qiu, Weijun Fan, Penghui Zhou, Lujun Shen
Summary: IGF-1 and IGF-1R show inconsistent gene expression levels in various cancer cell lines, with high expression typically detected in most malignant tumors. High expression of IGF-1 is closely associated with unfavorable overall survival in BLCA, CHOL, and LAML patients, while high expression of IGF-1R is closely linked to poor overall survival in BLCA, LIHC, and LUAD patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Wei Tang, Qian Lv, Xiao Huang, Yuzhen Li, JunJie Zou, Jiaoyang Zheng, Liangliang Sun, Yi Bao, Haiyan Chen, Tuo Li, Bei Zhang, Song Xue, Yan Song, Xingxing Zhang, Xiangfang Chen, Jiping Cai, Yongquan Shi
Summary: This study found that miR-143 directly targets IGF-1R to alleviate the inflammatory response in TAO by indirectly decreasing levels of TSHR and NLRP3.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Ming Xiu, Xia Huan, Yang Ou, Sha Ying, Jianmeng Wang
Summary: The study investigated the cellular behavior and characteristics of IGF-1/IGF-1R in intestinal cells, revealing that IGF-1 can internalize into the cytoplasm and transport into the cell nuclei. It was found that IGF-1R undergoes clathrin-mediated endocytosis and enters into Rab-5-positive endosomes before being transported to the cell nuclei along microtubules, promoting cell proliferation.
CELL PROLIFERATION
(2021)
Article
Oncology
Shuhong Man, Xiaohan Li, Wei Zhu
Summary: This study reveals that PSMG3-AS1 is upregulated in CSCC tissues and its high expression levels predict poor survival, while miR-4417 is downregulated and inversely correlated with PSMG3-AS1. miR-4417 may target PSMG3-AS1 to suppress cancer cell invasion and migration in CSCC.
Article
Multidisciplinary Sciences
Song Wu, Tao Tang, Hongchi Zhou, Jing Huang, Xiaoliang Kang, Junli Zhang
Summary: This study reveals that LINC01343 acts as a crucial oncogene in hepatocellular carcinoma (HCC). LINC01343 negatively regulates the expression of miR-526b-5p, which in turn modulates ROBO1 expression, affecting HCC cell proliferation and migration.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Zhiqing Cheng, Limei Gong, Qinghe Cai
Summary: This study found that LINC00978 is upregulated in HCC and is associated with poor prognosis. Silencing LINC00978 can inhibit the growth and metastasis of HCC cells. Mechanistically, LINC00978 functions as a sponge for miR-125b-5p and regulates the expression of SOX12, promoting liver cancer migration, invasion, and proliferation.
Article
Environmental Sciences
Yujie Tan, Hao Wang, Chan Zhang
Summary: The study revealed that miRNA-381 is downregulated in human cervical cancer, and its tumor-suppressive effects are mediated through the regulation of GPR34 gene, leading to inhibition of proliferation and migration of cervical cancer cells, as well as induction of cell apoptosis. Targeting the miRNA-381/GPR34 axis may represent a potential therapeutic approach for human cervical cancer.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Wenqi Chen, Yuehua Li, Jing Zhong, Gebo Wen
Summary: The study elucidated that circ-PRKCI may promote the viability, invasion and migration of HCC cells by sponging miR-1294 and miR-186-5p to upregulate FOXK1 expression levels.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Xun Zhang, Zhong Yao, Zhiyi Xue, Shuai Wang, Xuemeng Liu, Yaotian Hu, Yan Zhang, Jian Wang, Xingang Li, Anjing Chen
Summary: Resibufogenin (RB), a major component of traditional Chinese medicine Chansu, has shown potential in cancer treatment. This study found that RB induced G2/M phase arrest and inhibited invasion in glioblastoma cells. The mechanism involves the downregulation of CDC25C and upregulation of p21 through the MAPK/ERK pathway, as well as the elevation of intracellular Ca2+ to suppress the Src/FAK/Paxillin focal adhesion pathway. RB binds to ATP1A1, activating Na+-K+-ATPase and triggering the MAPK/ERK pathway and Ca2+-mediated Src/FAK/Paxillin pathway, resulting in G2/M phase arrest and inhibition of invasion in glioblastoma cells.
FRONTIERS IN PHARMACOLOGY
(2022)