Article
Food Science & Technology
Wei-Jian Li, Xuan Zhang, Ming Shen, Hong-Lin Liu, Li-Ren Ding
Summary: This study investigated the cytotoxicity of 3-Nitropropionic acid (3-NP) during mouse oocyte maturation and the protective effects of Sulforaphane (SFN). The results showed that 3-NP inhibited oocyte maturation in a dose-dependent manner, while SFN significantly alleviated the defects caused by 3-NP. In addition, 3-NP disrupted mitochondrial functions in oocytes, leading to oxidative stress and increased apoptosis. SFN supplementation had significant cytoprotective effects, mitigating these damages.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junjie Du, Dongmin Yu, Jinghang Li, Linjie Si, Dawei Zhu, Ben Li, Yizhou Gao, Lifu Sun, Xufeng Wang, Xiaowei Wang
Summary: Through mouse experiments and in vitro cell experiments, it was found that Asiatic acid (AA) enhances the survival of cardiomyocytes and alleviates cardiac dysfunction by protecting mitochondrial structure, reducing oxidative stress, inhibiting mitochondrial-dependent apoptosis pathway, and inhibiting the activation of the JNK pathway, which highlights its potential therapeutic value in chronic pressure overload-induced heart failure and oxidative stress-induced cardiomyocyte apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Organic
Min Peng, Quan-Rong Du, Xue Yao, Chun-Ni Li, Yang Tian, Yu Peng, Ya-Wen Wang
Summary: A simple fluorescein derivative was synthesized as a fluorescent probe for detecting malondialdehyde (MDA). The probe achieved ring-opening of fluorescein and formation of a benzohydrazide derivative through a synergistic reaction. It exhibited high sensitivity and selectivity for MDA detection, and could quickly and visually detect MDA within 60 s using UV-vis and fluorescent modes. Moreover, the probe showed excellent performance in imaging MDA in living cells and bacteria.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Arunraj Namachivayam, Abilash Valsala Gopalakrishnan
Summary: This study investigated the protective effects of lauric acid (LA) against ethanol-induced hepatotoxicity. The results showed that LA alleviated oxidative stress, lipid peroxidation, inflammation, and apoptosis caused by ethanol. Additionally, LA upregulated the expression of HNF4 alpha.
Article
Agriculture, Dairy & Animal Science
Dan Xu, Lizi Yin, Juchun Lin, Hualin Fu, Xi Peng, Lijen Chang, Yilei Zheng, Xiaoling Zhao, Gang Shu
Summary: Aristolochic acid (AA) is a component of traditional Chinese herbs and commonly used for farm animals in China. Over-exposure to AA has been associated with hepatotoxicity, and this study reveals that AA-I-induced hepatotoxicity is linked to oxidative-stress-mediated apoptosis and mitochondrial damage.
Article
Cell Biology
Yan Che, Zhaopeng Wang, Yuan Yuan, Heng Zhou, Haiming Wu, Shasha Wang, Qizhu Tang
Summary: Corosolic acid (CRA) has shown protective effects against doxorubicin (Dox)-induced cardiotoxicity by promoting transcription factor EB (TFEB) nuclear translocation, reducing apoptosis, and decreasing oxidative stress. CRA activates TFEB in an AMPK alpha 2-dependent manner to protect against Dox cardiotoxicity by restoring autophagic flux and improving mitochondrial structure and function.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Daria Mrugala, Jessica L. Leatherwood, Elizabeth F. Morris, Emily C. Dickson, Christine M. Latham, Randi N. Owen, Marcy M. Beverly, Stanley F. Kelley, Sarah H. White-Springer
Summary: Conjugated linoleic acid (CLA) supplementation in lightly exercising horses may result in mitochondrial adaptations and protection against myofiber perturbation in skeletal muscle. Significant differences were observed in mitochondrial enzyme activities and antioxidant status between horses supplemented with soybean oil and CLA. Superoxide dismutase activity tended to increase over time in the soybean oil group, while glutathione peroxidase activity tended to be higher in the soybean oil group compared to the CLA group at week 12.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jonas Knittel, Nadja Itani, Rolf Schreckenberg, Jacqueline Heger, Susanne Rohrbach, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Serotonin effects on cardiac hypertrophy, senescence, and failure depend on specific receptors or serotonin uptake and degradation by MAOs. MAO-dependent effects are non-specific. MAOA expression increases in maladaptive hypertrophic stages. MAO-A inhibition suppresses serotonin-dependent damage. Serotonin induces mitochondria-dependent oxidative stress.
Article
Pharmacology & Pharmacy
Zaib Ali Shaheryar, Mahtab Ahmad Khan, Huma Hameed, Syed Awais Ali Zaidi, Irfan Anjum, Muhammad Shafeeq Ur Rahman
Summary: Higher glucose levels during ischemic stroke contribute to worse outcomes. This is primarily due to the production of reactive, toxic glucose metabolites that cause oxidative damage in the brain. As a result, the microvasculature structures and tight junctions are compromised, leading to increased infarct volume and exacerbated brain edema.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pamela A. Kakimoto, Julian David C. Serna, Vitor de Miranda Ramos, Antonio Zorzano, Alicia J. Kowaltowski
Summary: Exposure to toxic levels of fatty acids leads to cell damage and death, contributing to the pathogenesis of the metabolic syndrome. Lipotoxicity induces changes in mitochondrial morphology and increases glycolytic flux in cells, while oxidative phosphorylation remains unchanged.
Article
Dentistry, Oral Surgery & Medicine
Junsheng Chen, Yarong Zhang, Jing Gao, Tao Li, Xueqi Gan, Haiyang Yu
Summary: The study found that reduced levels of SIRT3 in aged mice's alveolar bones were associated with increased protein acetylation levels. Aged SIRT3-KO mice showed the highest bone resorption rate and largest number of TRAP-positive osteoclasts. Additionally, SIRT3 deficiency led to increased reactive oxygen species levels and mitochondrial dysfunction, indicating a role in age-related periodontal disease.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kristina Wardelmann, Michaela Rath, Jose Pedro Castro, Sabine Bluemel, Mareike Schell, Robert Hauffe, Fabian Schumacher, Tanina Flore, Katrin Ritter, Andreas Wernitz, Toru Hosoi, Koichiro Ozawa, Burkhard Kleuser, Jurgen Weiss, Annette Schurmann, Andre Kleinridders
Summary: Research indicates that reduced Hsp10 expression in the brains of type 2 diabetes mice is regulated by leptin in vitro. Decreased Hsp10 in hypothalamic cells leads to mitochondrial dysfunction and insulin resistance.
Article
Biochemistry & Molecular Biology
Tae Woo Jung, Eui Jin Hwang, Do Hyeon Pyun, Tae Jin Kim, Hyun Jung Lee, A. M. Abd El-Aty, Joon Seok Bang, Hyoung-Chun Kim, Ji Hoon Jeong
Summary: 3-hydroxymorphinan (3-HM) promotes mitochondrial biogenesis and browning, attenuates oxidative stress and lipid accumulation in adipocytes via AMPK signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Neoma T. Boardman, Baher Migally, Chantal Pileggi, Gaganvir S. Parmar, Jian Ying Xuan, Keir Menzies, Mary-Ellen Harper
Summary: GRX2 and SIRT3 play important roles in controlling cardiac mitochondrial redox and oxidative processes. However, their combined absence does not exacerbate effects, consistent with the overall conclusion that they function together in the complex redox and antioxidant systems in the heart.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Chemistry, Applied
Xiazhen Bao, Kaili Ai, Xuehui Cao, Dongping Chen, Bo Zhou, Congde Huo
Summary: Bioactive small molecules HClO and SO2 are crucial for maintaining normal physiological function. A newly developed dual-site and dual-turn-on fluorescence probe PTBI can simultaneously monitor these molecules in mitochondria, with fast response and low detection limits, providing a powerful tool for studying their physiological and pathological roles.