Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss

The unfolded protein response: mechanisms and therapy of neurodegeneration

(2016) Heather L. Smith et al.   BRAIN

Endoplasmic reticulum stress in human photoreceptor diseases

(2016) Priscilla Chan et al.   BRAIN RESEARCH

Optic neuritis as a phase 2 paradigm for neuroprotection therapies of multiple sclerosis

(2016) Orhan Aktas et al.   CURRENT OPINION IN NEUROLOGY

Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules

(2016) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Harnessing the integrated stress response for the treatment of multiple sclerosis

(2016) Sharon W Way et al.   LANCET NEUROLOGY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

(2016) Linqing Miao et al.   eLife

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives

(2015) Daniel Ontaneda et al.   LANCET NEUROLOGY

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia

(2015) Susanne Kohl et al.   NATURE GENETICS

Oligodendrocyte death results in immune-mediated CNS demyelination

(2015) Maria Traka et al.   NATURE NEUROSCIENCE

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

(2015) M Halliday et al.   Cell Death & Disease

Vision and vision-related outcome measures in multiple sclerosis

(2014) L. J. Balcer et al.   BRAIN

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Genetic inactivation of PERK signaling in mouse oligodendrocytes: Normal developmental myelination with increased susceptibility to inflammatory demyelination

(2014) Yassir Hussien et al.   GLIA

Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction

(2014) R. Villegas et al.   JOURNAL OF NEUROSCIENCE

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

(2014) P. Valdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration

(2014) Liu Yang et al.   Nature Communications

Neuronal endoplasmic reticulum stress in axon injury and neurodegeneration

(2013) Shaohua Li et al.   ANNALS OF NEUROLOGY

Oligodendrocyte-Specific Activation of PERK Signaling Protects Mice against Experimental Autoimmune Encephalomyelitis

(2013) W. Lin et al.   JOURNAL OF NEUROSCIENCE

A Comprehensive Review of Retinal Gene Therapy

(2013) Shannon E Boye et al.   MOLECULAR THERAPY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

(2013) Marek Ma et al.   NEUROBIOLOGY OF DISEASE

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination

(2013) Mary Ní Fhlathartaigh et al.   Acta Neuropathologica Communications

A Thrombospondin-Dependent Pathway for a Protective ER Stress Response

(2012) Jeffrey M. Lynch et al.   CELL

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

(2012) Gareth R. Howell et al.   EXPERIMENTAL NEUROLOGY

Axon degeneration: Molecular mechanisms of a self-destruction pathway

(2012) Jack T. Wang et al.   JOURNAL OF CELL BIOLOGY

Increased expression of ER stress- and hypoxia-associated molecules in grey matter lesions in multiple sclerosis

(2012) JM McMahon et al.   Multiple Sclerosis Journal

Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells

(2012) Yang Hu et al.   NEURON

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

(2012) V Valenzuela et al.   Cell Death & Disease

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

(2012) Zoe Fonseca-Kelly et al.   Frontiers in Neurology

Autophagy and BiP level decrease are early key events in retrograde degeneration of motoneurons

(2011) C Penas et al.   CELL DEATH AND DIFFERENTIATION

Systemic Adeno-Associated Virus-Mediated Gene Therapy Preserves Retinal Ganglion Cells and Visual Function in DBA/2J Glaucomatous Mice

(2011) Timothy A. Sullivan et al.   HUMAN GENE THERAPY

Neuroinflammation and Endoplasmic Reticulum Stress Are Coregulated by Crocin To Prevent Demyelination and Neurodegeneration

(2011) A. M. Deslauriers et al.   JOURNAL OF IMMUNOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Optic Neuritis and Retinal Ganglion Cell Loss in a Chronic Murine Model of Multiple Sclerosis

(2011) Thomas A. Quinn et al.   Frontiers in Neurology

Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury

(2010) Maryla Krajewska et al.   BRAIN RESEARCH

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Endoplasmic reticulum stress in disorders of myelinating cells

(2009) Wensheng Lin et al.   NATURE NEUROSCIENCE

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

Axonal loss and myelin in early ON loss in postacute optic neuritis

(2008) Alexander Klistorner et al.   ANNALS OF NEUROLOGY

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Comparative analysis of in vivo and in vitro AAV vector transduction in the neonatal mouse retina: Effects of serotype and site of administration

(2007) Ji-jing Pang et al.   VISION RESEARCH