Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

Investigating the effect of 28 BRCA1 and BRCA2 mutations on their related transcribed mRNA

(2016) Francisco Quiles et al.   BREAST CANCER RESEARCH AND TREATMENT

Splicing controls the ubiquitin response during DNA double-strand break repair

(2016) C Pederiva et al.   CELL DEATH AND DIFFERENTIATION

Alternative splicing and cell survival: from tissue homeostasis to disease

(2016) Maria Paola Paronetto et al.   CELL DEATH AND DIFFERENTIATION

BRCA2 minor transcript lacking exons 4–7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation

(2016) Eswary Thirthagiri et al.   HUMAN MOLECULAR GENETICS

Naturally occurringBRCA2alternative mRNA splicing events in clinically relevant samples

(2016) James D Fackenthal et al.   JOURNAL OF MEDICAL GENETICS

SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability

(2016) Chao Huang et al.   Cell Reports

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

(2015) R. Gonzalez-Prieto et al.   EMBO REPORTS

BRCA2 Phosphorylated by PLK1 Moves to the Midbody to Regulate Cytokinesis Mediated by Nonmuscle Myosin IIC

(2014) M. Takaoka et al.   CANCER RESEARCH

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2014) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

Capillary Electrophoresis Analysis of Conventional Splicing Assays: IARC Analytical and Clinical Classification of 31BRCA2Genetic Variants

(2013) Gorka Ruiz de Garibay et al.   HUMAN MUTATION

Fanconi anaemia,BRCA2mutations and childhood cancer: a developmental perspective from clinical and epidemiological observations with implications for genetic counselling

(2013) Stefan Meyer et al.   JOURNAL OF MEDICAL GENETICS

Analysis of DNA Repair-Related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response

(2013) M. J. Garcia et al.   MOLECULAR CANCER THERAPEUTICS

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

(2013) Molly C. Kottemann et al.   NATURE

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization

(2013) Anand D Jeyasekharan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Comparative In Vitro and In Silico Analyses of Variants in Splicing Regions of BRCA1 and BRCA2 Genes and Characterization of Novel Pathogenic Mutations

(2013) Mara Colombo et al.   PLoS One

ModuLand plug-in for Cytoscape: determination of hierarchical layers of overlapping network modules and community centrality

(2012) Máté Szalay-Bekő et al.   BIOINFORMATICS

FANCL ubiquitinates  -catenin and enhances its nuclear function

(2012) K.-H. T. Dao et al.   BLOOD

Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma

(2012) Stephanie Smetsers et al.   Familial Cancer

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay

(2012) Kajal Biswas et al.   HUMAN MOLECULAR GENETICS

Multiple sequence variants ofBRCA2exon 7 alter splicing regulation

(2012) Pascaline Gaildrat et al.   JOURNAL OF MEDICAL GENETICS

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

(2012) Britt Adamson et al.   NATURE CELL BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Synthetic lethality: exploiting the addiction of cancer to DNA repair

(2011) M. Shaheen et al.   BLOOD

A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay

(2011) K. Biswas et al.   BLOOD

Secondary Somatic Mutations Restoring BRCA1/2 Predict Chemotherapy Resistance in Hereditary Ovarian Carcinomas

(2011) Barbara Norquist et al.   JOURNAL OF CLINICAL ONCOLOGY

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1

(2010) S. Lugthart et al.   BLOOD

Gene Expression Profile ofBRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer

(2010) Panagiotis A. Konstantinopoulos et al.   JOURNAL OF CLINICAL ONCOLOGY

TLR8-dependent TNF-  overexpression in Fanconi anemia group C cells

(2009) S. M. Vanderwerf et al.   BLOOD

Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2-Mutated Ovarian Carcinoma

(2009) W. Sakai et al.   CANCER RESEARCH

A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS)

(2009) Richard D Unwin et al.   Nature Protocols

Targeted therapy for cancer using PARP inhibitors

(2008) Christopher J Lord et al.   CURRENT OPINION IN PHARMACOLOGY

Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response

(2008) J. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

Resistance to therapy caused by intragenic deletion in BRCA2

(2008) Stacey L. Edwards et al.   NATURE

Mouse embryonic stem cell–based functional assay to evaluate mutations in BRCA2

(2008) Sergey G Kuznetsov et al.   NATURE MEDICINE

Inherited Susceptibility to Common Cancers

(2008) William D. Foulkes   NEW ENGLAND JOURNAL OF MEDICINE