Simvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis

Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF

(2016) Young-So Yoon et al.   Scientific Reports

PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines

(2015) Y-S Yoon et al.   Mucosal Immunology

Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock

(2014) Y. Ren et al.   JOURNAL OF IMMUNOLOGY

The Effect of Statin on Epithelial-Mesenchymal Transition in Peritoneal Mesothelial Cells

(2014) Tae Ik Chang et al.   PLoS One

Alveolar Type II Epithelial Cell Dysfunction in Rat Experimental Hepatopulmonary Syndrome (HPS)

(2014) Wenli Yang et al.   PLoS One

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion

(2014) Katsuhiko Warita et al.   Scientific Reports

Effects of simvastatin on pulmonary fibrosis, pulmonary hypertension and exercise capacity in bleomycin-treated rats

(2013) S. Schroll et al.   Acta Physiologica

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

(2013) Hang-Lung Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effects of simvastatin on bleomycin-induced pulmonary fibrosis in female rats

(2013) Baykal Tulek et al.   BIOLOGICAL RESEARCH

Simvastatin Attenuates TGF-�1-Induced Epithelial-Mesenchymal Transition in Human Alveolar Epithelial Cells

(2013) Tuo Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Coordinated induction of cyclooxygenase-2/prostaglandin E2 and hepatocyte growth factor by apoptotic cells prevents lung fibrosis

(2013) Young-So Yoon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pulmonary Abnormalities in Animal Models Due to Niemann-Pick Type C1 (NPC1) or C2 (NPC2) Disease

(2013) Blair R. Roszell et al.   PLoS One

Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction

(2012) Ye-Ji Lee et al.   EUROPEAN RESPIRATORY JOURNAL

Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

(2012) Chunguo Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation

(2012) Jochen Grommes et al.   PLoS One

Defective efferocytosis by alveolar macrophages in IPF patients

(2012) Konosuke Morimoto et al.   RESPIRATORY MEDICINE

Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways

(2011) Olorunseun O. Ogunwobi et al.   CLINICAL & EXPERIMENTAL METASTASIS

Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis in the Regeneration/Healing Process from TNBS-Induced Colitis

(2011) Yosuke Abe et al.   DIGESTIVE DISEASES AND SCIENCES

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

Hepatocyte growth factor in lung repair and pulmonary fibrosis

(2010) Ronald Allan M Panganiban et al.   ACTA PHARMACOLOGICA SINICA

Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and β-catenin/Wnt pathways

(2010) Sara Previdi et al.   EUROPEAN JOURNAL OF CANCER

Emerging Concepts in the Pathogenesis of Lung Fibrosis

(2009) William D. Hardie et al.   AMERICAN JOURNAL OF PATHOLOGY

N-Acetylcysteine Inhibits RhoA and Promotes Apoptotic Cell Clearance during Intense Lung Inflammation

(2009) Changsuk Moon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Statins inhibit matrix metalloproteinase release from human lung fibroblasts

(2009) K. Kamio et al.   EUROPEAN RESPIRATORY JOURNAL

HGF and BMP-7 Ameliorate High Glucose-Induced Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelium

(2009) M.-A Yu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?

(2009) Sylvain Perruche et al.   ARTHRITIS RESEARCH & THERAPY

Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα

(2008) William J. Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hepatocyte Growth Factor Inhibits Epithelial to Myofibroblast Transition in Lung Cells via Smad7

(2008) Manasi N. Shukla et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY