Article
Plant Sciences
Antonietta Saccomanno, Martin Potocky, Premysl Pejchar, Michal Hala, Hiromasa Shikata, Claus Schwechheimer, Viktor Zarsky
Summary: The study investigated the phosphorylation regulation of exocyst isoform EXO70C2, showing that changes in phosphorylation status can affect pollen tube growth rate and cellular architecture, with different outcomes in wild type and exo70c2 mutant cells. Phosphorylation of AtEXO70C2 does not affect its cytoplasmic localization or interaction with putative secretion inhibitor ROH1 in the yeast two-hybrid system.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Developmental Biology
Kumari Pushpa, Sunayana Dagar, Harsh Kumar, Diksha Pathak, Sivaram V. S. Mylavarapu
Summary: The study demonstrates that the exocyst complex regulates germline stem cell proliferation by modulating Notch signaling autonomously in the nematode Caenorhabditis elegans. Additionally, the exocyst complex interacts with other cellular components to maintain optimal membrane Notch levels and is required for Notch plasma membrane localization and signaling in mammalian cells.
Article
Plant Sciences
Fan Wang, Zhijun Cheng, Jiachang Wang, Feng Zhang, Baocai Zhang, Sheng Luo, Cailin Lei, Tian Pan, Yongfei Wang, Yun Zhu, Min Wang, Weiwei Chen, Qibing Lin, Shanshan Zhu, Yihua Zhou, Zhichao Zhao, Jie Wang, Xiuping Guo, Xin Zhang, Ling Jiang, Yiqun Bao, Yulong Ren, Jianmin Wan
Summary: This study identified a rice mutant, dph1-1, with limited cell expansion, resulting in reduced plant height and smaller panicles and grains. The protein OsSCD2, homologous to Arabidopsis SCD2, was found to be associated with clathrin and involved in defective endocytosis and post-Golgi trafficking in the dph1-1 mutant. The mutant also displayed impaired cellulose synthesis. These findings suggest that OsSCD2 plays a crucial role in clathrin-related vesicular trafficking and is important for maintaining plant growth in rice.
Article
Biochemistry & Molecular Biology
Joao Neves, Miguel Sampaio, Ana Seneca, Susana Pereira, Jose Pissarra, Claudia Pereira
Summary: Plants respond to abiotic stress by remodeling their endomembranes and adapting their trafficking pathways. Differential gene expression related to protein trafficking machinery leads to alterations in cell ultrastructure under stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kazuo Katoh
Summary: The study revealed that Src protein tyrosine kinases play crucial roles in cell polarity formation and elongation, with the expression and regulation of Src being essential for polarity formation during cell elongation.
Article
Multidisciplinary Sciences
Alison Boutet, Carlos Zeledon, Gregory Emery
Summary: Chemotaxis is important for diverse migrations in development and diseases like cancer progression. In this study, the researchers investigated the role of ArfGAP1 in regulating chemotaxis during collective cell migration. They found that ArfGAP1 is required to maintain receptor tyrosine kinases at the plasma membrane, and its absence leads to decreased active receptors and increased late endosomes. They also observed increased late endosomes and lysosomes in the absence of ArfGAP1, and identified genetic interactions with Lrrk in receptor sorting.
Article
Multidisciplinary Sciences
Lukas Synek, Roman Pleskot, Juraj Sekeres, Natalia Serrano, Nemanja Vukasinovic, Jitka Ortmannova, Martina Klejchova, Premysl Pejchar, Klara Batystova, Malgorzata Gutkowska, Edita Jankova-Drdova, Vedrana Markovic, Tamara Pecenkova, Jiri Santrucek, Viktor Zarsky, Martin Potocky
Summary: The study reveals plant-specific features of the exocyst complex and emphasizes the importance of the specific protein-lipid code for the recruitment of peripheral membrane proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Plant Sciences
Huibin Han, Maciek Adamowski, Linlin Qi, Saqer S. Alotaibi, Jiri Friml
Summary: Plants exhibit differential growth responses through the coordination of auxin hormone and PIN auxin exporters during tropisms, which are regulated by environmental stimuli. Auxin gradients promote cell elongation and bending, with auxin feedback playing a crucial role in PIN polarity during bending termination. Interactions between different tropisms are reviewed to enhance understanding of plant adaptive growth in the natural environment.
Article
Biochemistry & Molecular Biology
Christina D. Cota, Matthew S. Dreier, William Colgan, Anna Cha, Twan Sia, Brad Davidson
Summary: The study delineates the role of mitotic kinases in receptor trafficking during asymmetric division, with CDK1 and Aurora Kinase regulating degradation and recycling pathways. Mitotic receptor storage may facilitate rapid reestablishment of signaling competence in nascent daughter cells, but mutations affecting the release of stored components could alter daughter cell fate or promote oncogenesis.
Article
Biochemistry & Molecular Biology
Xiaoyun Tan, Haoyue Xu, Jie Ye, Jin Wang, Wenlong Liu, Feng Liu, Qingchen Rui, Yiqun Bao
Summary: The exocyst subunit SEC6 plays an important role in cell plate formation during pollen mitosis I and might help to tether the vesicles before fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Matthew J. E. Logue, Rachel E. Farquhar, Yoakim Eckhoff-Bjorngard, Tanya T. Cheung, Daniel C. Devor, Fiona J. McDonald, Kirk L. Hamilton
Summary: Control of ion and water movement across epithelia is crucial for maintaining homeostasis. The exocyst complex plays a crucial role in regulating the connection between KCa3.1 ion channels and the basolateral membrane in epithelial cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Lucie Brejskova, Michal Hala, Anamika Rawat, Hana Soukupova, Fatima Cvrckova, Florence Charlot, Fabien Nogue, Samuel Haluska, Viktor Zarsky
Summary: This study identified the important roles of PpSEC6 and AtSEC6 in gametophore development of moss, demonstrating the specific functions of SEC6 in plant growth and development.
Review
Plant Sciences
Qian Ma, Mingqin Chang, Georgia Drakakaki, Eugenia Russinova
Summary: The endomembrane system is crucial for plant growth and development. Small-molecule compounds have been used as powerful tools to study membrane trafficking in plant cells, but more precise chemical probes are needed for a better understanding of the complex trafficking processes. Various chemoproteomic approaches can help determine the mechanism of action of compounds and improve their specificity. Rational molecule design, virtual screening, and artificial intelligence can aid in the discovery of highly precise chemical probes more efficiently. In the next decade, more accurate tools and advanced live quantitative imaging techniques will deepen our insights into the plant endomembrane system.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Review
Cell Biology
Siamak A. Kamranvar, Bhavna Rani, Staffan Johansson
Summary: Cell cycle and cell adhesion are interdependent cellular processes that regulate each other through signaling pathways. Recent studies have shown that integrin-mediated cell adhesion plays an important role in the regulation of the cell cycle, particularly during the G2 and early M phases.
Article
Multidisciplinary Sciences
Di Feng, Jin Wang, Wei Yang, Jingyu Li, Xiaochen Lin, Fangzi Zha, Xiaolu Wang, Luyao Ma, Nga Ting Choi, Yusuke Mii, Shinji Takada, Michael S. Y. Huen, Yusong Guo, Liang Zhang, Bo Gao
Summary: The proteins Vangl1 and Vangl2 are crucial components of Wnt/planar cell polarity signaling, regulated by the ubiquitin-proteasome system through endoplasmic reticulum-associated degradation. The ERAD component p97/VCP binds to Vangl and recruits E3 ligase KBTBD7 to promote Vangl ubiquitination and degradation, while Wnt5a/CK1 prevents Vangl degradation by inducing phosphorylation for plasma membrane export.
Article
Cell Biology
Noemi Polgar, Amanda J. Lee, Vanessa H. Lui, Josephine A. Napoli, Ben Fogelgren
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2015)
Article
Multidisciplinary Sciences
Ben Fogelgren, Noemi Polgar, Vanessa H. Lui, Amanda J. Lee, Kadee-Kalia A. Tamashiro, Josephine Andrea Napoli, Chad B. Walton, Xiaofeng Zuo, Joshua H. Lipschutz
Article
Cell Biology
Ceclia Seixas, Soo Young Choi, Noemi Polgar, Nicole L. Umberger, Michael P. East, Xiaofeng Zuo, Hugo Moreiras, Rania Ghossoub, Alexandre Benmerah, Richard A. Kahn, Ben Fogelgren, Tamara Caspary, Joshua H. Lipschutz, Duarte C. Barral
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Immunology
Blanka Kellermayer, Noemi Polgar, Jozsef Pal, Miklos Banati, Anita Maasz, Peter Kisfali, Zsolt Hosszu, Annamaria Juhasz, Henrik Boye Jensen, Attila Tordai, Csilla Rozsa, Bela Melegh, Zsolt Illes
Article
Genetics & Heredity
Elisa Grillo, Laurent Villard, Angus Clarke, Bruria Ben Zeev, Mercedes Pineda, Nadia Bahi-Buisson, Anna Hryniewiecka-Jaworska, Thierry Bienvenu, Judith Armstrong, Ana Roche Martinez, Francesca Mari, Edvige Veneselli, Silvia Russo, Aglaia Vignoli, Giorgio Pini, Milena Djuric, Anne-Marie Bisgaard, Vlatka Mejaski Bosnjak, Noemi Polgar, Francesca Cogliati, Kirstine Ravn, Maria Pintaudi, Bela Melegh, Dana Craiu, Aleksandra Djukic, Alessandra Renieri
Article
Gastroenterology & Hepatology
Veronika Csoengei, Luca Jaromi, Eniko Safrany, Csilla Sipeky, Lili Magyari, Noemi Polgar, Judit Bene, Patricia Sarlos, Lilla Lakner, Eszter Baricza, Melinda Szabo, Gabor Rappai, Bela Melegh
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2011)
Article
Genetics & Heredity
N. Polgar, V. Csongei, M. Szabo, V. Zambo, B. I. Melegh, K. Sumegi, G. Nagy, Z. Tulassay, B. Melegh
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2012)
Article
Pediatrics
Katalin Horvatovich, Szilvia Bokor, Akos Barath, Anita Maasz, Peter Kisfali, Luca Jaromi, Noemi Polgar, Denes Toth, Judit Repasy, Emoke Endreffy, Denes Molnar, Bela Melegh
INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY
(2011)
Article
Genetics & Heredity
Kinga Hadzsiev, Noemi Polgar, Judit Bene, Katalin Komlosi, Judit Karteszi, Katalin Hollody, Gyorgy Kosztolanyi, Alessandra Renieri, Bela Melegh
JOURNAL OF HUMAN GENETICS
(2011)
Article
Neurosciences
Luca Jaromi, Veronika Csoengei, Noemi Polgar, Gabor Rappai, Zoltan Szolnoki, Anita Maasz, Katalin Horvatovich, Eniko Safrany, Csilla Sipeky, Lili Magyari, Bela Melegh
NEUROMOLECULAR MEDICINE
(2011)
Article
Multidisciplinary Sciences
Amanda J. Lee, Noemi Polgar, Josephine A. Napoli, Vanessa H. Lui, Kadee-Kalia Tamashiro, Brent A. Fujimoto, Karen S. Thompson, Ben Fogelgren
SCIENTIFIC REPORTS
(2016)
Article
Endocrinology & Metabolism
Brent A. Fujimoto, Madison Young, Lamar Carter, Anna P. S. Pang, Michael J. Corley, Ben Fogelgren, Noemi Polgar
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Xiaofeng Zuo, Sang-Ho Kwon, Michael G. Janech, Yujing Dang, Steven D. Lauzon, Ben Fogelgren, Noemi Polgar, Joshua H. Lipschutz
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Physiology
Ben Fogelgren, Xiaofeng Zuo, Janine M. Buonato, Aleksandr Vasilyev, Jeong-In Baek, Soo Young Choi, Maria F. Chacon-Heszele, Aurelien Palmyre, Noemi Polgar, Iain Drummond, Kwon Moo Park, Matthew J. Lazzara, Joshua H. Lipschutz
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2014)