EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients

Recent advances of highly selective CDK4/6 inhibitors in breast cancer

(2017) Hanxiao Xu et al.   Journal of Hematology & Oncology

Using game theory to investigate the epigenetic control mechanisms of embryo development

(2017) Le Zhang et al.   Physics of Life Reviews

Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia

(2017) Mengning Wang et al.   Stem Cells International

Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma

(2016) Maria Böhm et al.   JOURNAL OF CLINICAL INVESTIGATION

The comparison of clinical and biological characteristics between IDH1 and IDH2 mutations in gliomas

(2016) Hao-Yuan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Investigation of mechanism of bone regeneration in a porous biodegradable calcium phosphate (CaP) scaffold by a combination of a multi-scale agent-based model and experimental optimization/validation

(2016) Le Zhang et al.   Nanoscale

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetics and Epigenetics of Glioblastoma: Applications and Overall Incidence of IDH1 Mutation

(2016) Aizhen Liu et al.   Frontiers in Oncology

DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders

(2016) Hanae Sato et al.   Frontiers in Oncology

dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes

(2016) Jagpreet Singh Nanda et al.   Scientific Reports

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation

(2015) J. Sperlazza et al.   BLOOD

Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma

(2015) Kouki Nio et al.   JOURNAL OF HEPATOLOGY

Novel 3D GPU based numerical parallel diffusion algorithms in cylindrical coordinates for health care simulation

(2015) Beini Jiang et al.   MATHEMATICS AND COMPUTERS IN SIMULATION

Network-based identification of feedback modules that control RhoA activity and cell migration

(2015) Tae-Hwan Kim et al.   Journal of Molecular Cell Biology

Elucidation of drivers of high-level production of lactates throughout a cancer development

(2015) Chi Zhang et al.   Journal of Molecular Cell Biology

Network biology approach to epithelial–mesenchymal transition in cancer metastasis: three stage theory

(2015) Hiroshi Tanaka et al.   Journal of Molecular Cell Biology

Reconfiguring phosphorylation signaling by genetic polymorphisms affects cancer susceptibility

(2015) Yongbo Wang et al.   Journal of Molecular Cell Biology

Walking on multiple disease-gene networks to prioritize candidate genes

(2015) Rui Jiang   Journal of Molecular Cell Biology

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma

(2015) Rachel D. Melamed et al.   Journal of Molecular Cell Biology

Diagnosing phenotypes of single-sample individuals by edge biomarkers

(2015) Wanwei Zhang et al.   Journal of Molecular Cell Biology

Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme

(2015) Sara Weirich et al.   Clinical Epigenetics

Characterization of p38 MAPK isoforms for drug resistance study using systems biology approach

(2014) Huiming Peng et al.   BIOINFORMATICS

Tumor-Suppressive miR148a Is Silenced by CpG Island Hypermethylation in IDH1-Mutant Gliomas

(2014) S. Li et al.   CLINICAL CANCER RESEARCH

Multiscale agent-based modelling of ovarian cancer progression under the stimulation of the STAT 3 pathway

(2014) Le Zhang et al.   International Journal of Data Mining and Bioinformatics

Identification of a large protein network involved in epigenetic transmission in replicating DNA of embryonic stem cells

(2014) Sergi Aranda et al.   NUCLEIC ACIDS RESEARCH

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

(2014) Yakov Chudnovsky et al.   Cell Reports

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

(2014) Huiling Xu et al.   Cell Reports

D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma

(2014) Stefan Pusch et al.   Acta Neuropathologica Communications

Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

(2013) Hong Zhang et al.   CANCER CELL

IDH1 and IDH2 Mutations in Gliomas

(2013) Adam L. Cohen et al.   Current Neurology and Neuroscience Reports

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

(2013) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Large conserved domains of low DNA methylation maintained by Dnmt3a

(2013) Mira Jeong et al.   NATURE GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

(2012) Matthieu Le Gallo et al.   NATURE GENETICS

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

(2012) Akihiro Fujimoto et al.   NATURE GENETICS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

(2011) Luisa Cimmino et al.   Cell Stem Cell

Employing graphics processing unit technology, alternating direction implicit method and domain decomposition to speed up the numerical diffusion solver for the biomedical engineering research

(2011) Beini Jiang et al.   International Journal for Numerical Methods in Biomedical Engineering

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

(2011) C. Bettegowda et al.   SCIENCE

R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma

(2010) Susan C. Williams et al.   ACTA NEUROPATHOLOGICA

Association of a Leukemic Stem Cell Gene Expression Signature With Clinical Outcomes in Acute Myeloid Leukemia

(2010) Andrew J. Gentles   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

(2009) Takuya Watanabe et al.   AMERICAN JOURNAL OF PATHOLOGY

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas

(2009) Marc Sanson et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

DNA methylation is a guardian of stem cell self-renewal and multipotency

(2009) Laurraine-Marcelle Gereige et al.   NATURE GENETICS

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA