Orthoester functionalized N-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase

Pharmacological Chaperones: Design and Development of New Therapeutic Strategies for the Treatment of Conformational Diseases

(2016) Marino Convertino et al.   ACS Chemical Biology

Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases

(2016) Elena M. Sánchez-Fernández et al.   CHEMICAL COMMUNICATIONS

1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

(2016) Kuo Gao et al.   MOLECULES

Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase

(2016) Alen Sevšek et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases

(2015) Teresa Mena-Barragán et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human Acid β-Glucosidase Inhibition by Carbohydrate Derived Iminosugars: Towards New Pharmacological Chaperones for Gaucher Disease

(2015) Camilla Parmeggiani et al.   CHEMBIOCHEM

Pharmacological Chaperone Therapy: Preclinical Development, Clinical Translation, and Prospects for the Treatment of Lysosomal Storage Disorders

(2015) Giancarlo Parenti et al.   MOLECULAR THERAPY

Exploiting the Hydrophobic Terrain in Fucosidases with Aryl-Substituted Pyrrolidine Iminosugars

(2014) Audrey Hottin et al.   CHEMBIOCHEM

Glucocerebrosidase inhibitors: future drugs for the treatment of Gaucher disease?

(2014) Ana Trapero et al.   Future Medicinal Chemistry

Pharmacological chaperone therapy for lysosomal storage diseases

(2014) Giancarlo Parenti et al.   Future Medicinal Chemistry

Strain-specific antiviral activity of iminosugars against human influenza A viruses

(2014) S. Hussain et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

(2014) James A. Shayman et al.   JOURNAL OF LIPID RESEARCH

Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors

(2014) Amar T. Ghisaidoobe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingolipid lysosomal storage disorders

(2014) Frances M. Platt   NATURE

Searching for Glycomimetics That Target Protein Misfolding in Rare Diseases: Successes, Failures, and Unexpected Progress Made in Organic Synthesis

(2014) Philippe Compain   SYNLETT

Glucocerebrosidase inhibitors for the treatment of Gaucher disease

(2013) Ana Trapero et al.   Future Medicinal Chemistry

Small Molecules That Target Protein Misfolding

(2012) Lori Krim Gavrin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Aminocyclitol Glucocerebrosidase Inhibitors are Subnanomolar Pharmacological Chaperones for Treating Gaucher Disease

(2012) Ana Trapero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

(2012) Raymond Kooij et al.   MedChemComm

Iminosugars as therapeutic agents: recent advances and promising trends

(2011) Robert J Nash et al.   Future Medicinal Chemistry

Ex Vivoandin VivoEffects of Isofagomine on Acid β-Glucosidase Variants and Substrate Levels in Gaucher Disease

(2011) Ying Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification

(2010) Hélène Bruyère et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Simple method for fast deprotection of nucleosides by triethylamine-catalyzed methanolysis of acetates in aqueous medium

(2010) Lidiane Meier et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Glycosphingolipids-Nature, Function, and Pharmacological Modulation

(2009) Tom Wennekes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β-Glucosidase

(2009) Boris Brumshtein et al.   CHEMBIOCHEM

Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease

(2009) Guan-Nan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

NG-Aminoguanidines from Primary Amines and the Preparation of Nitric Oxide Synthase Inhibitors

(2008) Nathaniel I. Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preparation ofNG-Substitutedl-Arginine Analogues Suitable for Solid Phase Peptide Synthesis

(2008) Nathaniel I. Martin et al.   JOURNAL OF ORGANIC CHEMISTRY

A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

(2007) Jian-Qiang Fan   BIOLOGICAL CHEMISTRY