The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics

Changes in the expression of voltage-gated sodium channels Nav1.3, Nav1.7, Nav1.8, and Nav1.9 in rat trigeminal ganglia following chronic constriction injury

(2016) Wenhua Xu et al.   NEUROREPORT

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models

(2016) Thilo Focken et al.   ACS Medicinal Chemistry Letters

Retracted: Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation

(2015) Lingxin Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Voltage-gated sodium channel function and expression in injured and uninjured rat dorsal root ganglia neurons

(2015) Ruoyuan Yin et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

(2015) Jian Payandeh et al.   JOURNAL OF MOLECULAR BIOLOGY

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(2015) Andrew Tan et al.   MOLECULAR MEDICINE

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

(2015) Sharan K. Bagal et al.   ACS Medicinal Chemistry Letters

Recent progress in sodium channel modulators for pain

(2014) Sharan K. Bagal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Investigating the size and dynamics of voltage-gated sodium channel fenestrations

(2014) Joe A Kaczmarski et al.   Channels

Structural model of the open–closed–inactivated cycle of prokaryotic voltage-gated sodium channels

(2014) Claire Bagnéris et al.   JOURNAL OF GENERAL PHYSIOLOGY

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

(2014) C. Bagneris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of voltage-gated sodium channels at atomic resolution

(2013) William A. Catterall   EXPERIMENTAL PHYSIOLOGY

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel

(2013) M. B. Ulmschneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

(2012) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Virus-mediated shRNA Knockdown of Nav1.3 in Rat Dorsal Root Ganglion Attenuates Nerve Injury-induced Neuropathic Pain

(2012) Omar A Samad et al.   MOLECULAR THERAPY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons

(2010) Mark Estacion et al.   EXPERIMENTAL NEUROLOGY

Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?

(2009) Amit S. Kalgutkar et al.   CHEMISTRY & BIODIVERSITY

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

(2008) P. L. Sheets et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS