Investigation of Radial Mesoporous Bioactive Glass Particles as Drug Carriers for Inhibition of Tumor Cells

Radial mesoporous bioactive glass (rMBG) particles consisting of radical fibers were successfully synthesized by the sol-gel process. The particle size and fiber structure of rMBG were modulated by changing templates. All the particles contained internal mesoporous microstructure. Cetyl pyridine bromide assisted rMBG (CPB-rMBG) particles had relatively smaller particle size, longer radial fibers, and higher specific surface area and pore volume than cetyltrimethyl ammonium bromide assisted rMBG (CTAB-rMBG) particles. All the particles had good dispersion and could enter into the cells. The antitumor doxorubicin (DOX) drug loading efficiency of both CPB-rMBG and CTAB-rMBG particles was higher than 80%. They can be used as drug carriers to achieve a sustained release of the drugs. CCK8, live-dead cell staining and PI/annexinV double staining analysis showed that the drug particle complex exhibited good antitumor effects.