Article
Oncology
Zun Wang, Min Chen, Jing-Jing Liu, Rong-He Chen, Qian Yu, Gui-Mei Wang, Li-Ming Nie, Wen-He Huang, Guo-Jun Zhang
Summary: The study suggests that real-time in vivo visualization of breast cancer with a human serum albumin-decorated indocyanine green probe facilitates complete surgical resection of breast cancer in a mouse xenograft model.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hye Jung Jang, Myung Geun Song, Cho Rong Park, Hyewon Youn, Yun-Sang Lee, Gi Jeong Cheon, Keon Wook Kang
Summary: Glioblastoma is a common and fatal primary glioma, but complete removal of brain tumor tissues is challenging for neurosurgeons. Fluorescence-guided surgery (FGS) and indocyanine green (ICG) are used to enhance visualization of tumor edges. The binding properties of ICG to human serum albumin (HSA) and the extracellular glycoprotein SPARC were studied. In vitro and in vivo studies showed that the uptake of ICG-HSA complex was higher in SPARC-expressing glioblastoma cells and tumors compared to free ICG. This suggests that ICG-HSA complex could be an efficient imaging agent for SPARC-expressing tumors, especially glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Songah Jeong, Su Woong Yoo, Hea Ji Kim, Jieun Park, Ji Woo Kim, Changho Lee, Hyungwoo Kim
Summary: This review discusses the current state of PAI modality, recent progress on PAI imaging with carbon-based agents, and provides a future perspective on advanced PAI systems using carbon-based agents.
Article
Biochemistry & Molecular Biology
Niloofar Heshmati Aghda, Susana Torres Hurtado, Shahad M. Abdulsahib, Emilio J. Lara, James W. Tunnell, Tania Betancourt
Summary: This study focuses on using nanomedicine-mediated combination therapy to induce immunogenic cell death in melanoma cells by delivering ICD inducers Dox and ICG loaded into BSA nanoparticles, which inhibits tumor growth by enhancing the immunogenicity of the tumor microenvironment.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Engineering, Biomedical
Ruhao Wang, Cunfeng Song, Ang Gao, Qianwen Liu, Wenbin Guan, Jiawei Mei, Lijun Ma, Daxiang Cui
Summary: In this study, monoclonal antibody-conjugated liposomes loaded with indocyanine green (ICG) were developed for targeted photoacoustic imaging-guided sonodynamic therapy of Helicobacter pylori infection. The treatment successfully recognized and eliminated H. pylori without toxicity to normal tissues.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Elwin D. Clutter, Liaohai L. Chen, Rong R. Wang
Summary: This study aimed to investigate the factors affecting the photobleaching of indocyanine green (ICG) and its phototoxic effect on neuroblastoma cells. It was found that ICG photobleaching was significant only under aerobic conditions and more efficient in solutions with higher concentration of ICG monomers. While the binding of ICG monomers to BSA enhanced the photodynamic effect targeting cellular components, the photoproducts directly contributed to tumor growth inhibition and served as a secondary mechanism to stop tumor growth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Acoustics
Tingting Qiu, Chihan Peng, Lin Huang, Jinge Yang, Wenwu Ling, Jiawu Li, Hongjin Xiang, Yan Luo
Summary: Liver function reserve (LFR) is crucial in liver disease patients. The standard method for LFR evaluation is indocyanine green (ICG) clearance test, which can be performed using spectrophotometry or pulse dye densitometry (PDD). This study compared the accuracy of photoacoustic imaging (PAI) and PDD for LFR assessment in healthy volunteers, using spectrophotometry as the reference standard. The results showed a strong correlation between PAI and spectrophotometry (r = 0.9649, p < 0.0001). There was no significant difference in ICG clearance between PAI and spectrophotometry. These findings suggest that PAI could be a valuable noninvasive and accurate diagnostic tool for LFR assessment in humans.
Article
Chemistry, Medicinal
Sung Soo Kim, Hwang Kyung Kim, Hanju Kim, Woo Tak Lee, Eun Seong Lee, Kyung Taek Oh, Han-Gon Choi, Yu Seok Youn
Summary: Albumin nanoparticles loaded with paclitaxel, indocyanine green, and hyaluronidase showed excellent hyperthermal effects and cytotoxicity, with the ability to penetrate into three-dimensional tumor tissue structures and maintaining good colloidal stability.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Chemistry, Medicinal
Farrukh Zeeshan, Thiagarajan Madheswaran, Jithendra Panneerselvam, Rajeev Taliyan, Prashant Kesharwani
Summary: This article discusses the salient characteristics, design, and categories of albumin-based nanocarriers (ANCs) in the context of their application in cancer management. It also explores the fabrication methods, use in gene, cancer, and multimodal therapy, cancer diagnosis, and imaging of ANCs. Lastly, the article briefly covers the formulations, commercial products, and clinical testing of ANCs.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemical Research Methods
Van Phuc Nguyen, Jeff Folz, Yanxiu Li, Jessica Henry, Wei Zhang, Thomas Qian, Xueding Wang, Yannis M. Paulus
Summary: The combination of photoacoustic microscopy with indocyanine green and RGD peptides enables targeted imaging of CNV, improving imaging sensitivity and contrast, offering new insights for ophthalmology.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pengfei Li, Jiaqi Liu, Kunshan He, Shipeng Gong, Chongwei Chi, Pan Liu, Guidong Su, Weili Li, Hui Duan, Ping Liu, Jie Tian, Chunlin Chen
Summary: The feasibility and accuracy of near-infrared fluorescence (NIRF) imaging with indocyanine green (ICG) for detecting tumor invasion in cervical cancer was investigated. NIRF imaging enabled objective and accurate identification of tumor invasion during cervical cancer surgery.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Analytical
Xin Sun, Han Shan, Qibo Lin, Ziyan Chen, Dongxu Liu, Zhankai Liu, Kuan Peng, Zeyu Chen
Summary: This study utilized ICG-Lips and a dual-wavelength photoacoustic computed tomography (PACT) system to visualize the aggregation of ICG-Lips in tumors in real time, providing guidance for phototherapy. The work highlights the potential of PACT in real-time monitoring of in vivo drug distribution.
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Article
Oncology
Siyuan He, Ang Zhong, Jun Lei, Zhouming Deng, Xiaobin Zhu, Renxiong Wei, Huayi Huang, Zhenyi Chen, Lin Cai, Yuanlong Xie
Summary: In this study, we aimed to explore whether indocyanine green near-infrared fluorescence imaging can assist in the biopsy of bone and soft tissue tumors and improve the success rate of biopsy.
Article
Chemistry, Multidisciplinary
Luis D. B. Manuel, Vinoin Devpaul Vincely, Carolyn L. Bayer, Kevin M. McPeak
Summary: This study presents a highly reproducible synthesis route to monodisperse sub-100 nm Au nanoshells with an absorption-dominant optical response. Compared to commercially available nanoshells commonly used in nanomedicine, these sub-100 nm nanoshells show improved imaging depth and the potential for low-cost, low-fluence light-emitting diode utilization in photoacoustic imaging.
Article
Acoustics
Sangyeon Youn, Jin Woo Choi, Jun Su Lee, Jihun Kim, In-Hwan Yang, Jin Ho Chang, Hee Chan Kim, Jae Youn Hwang
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2019)
Article
Nanoscience & Nanotechnology
Haemin Kim, Hohyeon Lee, Hyungwon Moon, Jeeun Kang, Yongho Jang, Doyeon Kim, Jinwoo Kim, Elizabeth Huynh, Gang Zheng, Hyuncheol Kim, Jin Ho Chang
Article
Engineering, Biomedical
Junsu Lee, Jin Ho Chang
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2019)
Article
Engineering, Biomedical
Sunghun Park, Sungwoo Kang, Jin Ho Chang
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2020)
Article
Engineering, Biomedical
Jinhyoung Park, Changyang Lee, Junsu Lee, Jung-Ik Ha, Hongsoo Choi, Jin Ho Chang
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2020)
Article
Acoustics
Taewon Choi, Hwanseung Yu, Seoyun Chang, Dong-Heon Ha, Dong-Woo Cho, Jinah Jang, Changyang Lee, Gengxi Lu, Jin Ho Chang, Qifa Zhou, Jinhyoung Park
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2020)
Article
Acoustics
Sungwoo Kang, Junsu Lee, Jin Ho Chang
Summary: This study explores the effectiveness of using SAF and CFW methods for improving ultrasound IVUS imaging. It was found that applying CFW to the target scanline itself is beneficial for spatial resolution, while SAF is advantageous for enhancing the contrast-to-noise ratio. However, using focused IVUS transducers without these methods may be more advantageous for improving spatial and contrast resolution simultaneously due to system complexity.
Article
Computer Science, Interdisciplinary Applications
Jihun Kim, Hah Min Lew, Jung-Hee Kim, Sangyeon Youn, Hasan Al Faruque, An Na Seo, Soo Yeun Park, Jin Ho Chang, Eunjoo Kim, Jae Youn Hwang
Summary: The developed FL multimodal endoscopic system provides accurate information on tumor distribution from surface to deep tissue, which is crucial for determining cancer treatment plans. Experimental validation with phantoms and human colon tissue samples suggests that this system could be an innovative screening tool for quantitative tumor characterization.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Yongho Jang, Haemin Kim, Semi Yoon, Hohyeon Lee, Jangsun Hwang, Jaehun Jung, Jin Ho Chang, Jonghoon Choi, Hyuncheol Kim
Summary: In this study, tumor-derived reassembled exosome (R-Exo) was used both as a drug delivery carrier and an immunostimulatory agent for cancer therapy. By loading chlorin e6 photosensitizer into R-Exo, it retained its original size and membrane proteins for targeting tumor cells. The modified exosomes were able to generate reactive oxygen species and increase cytokine release from immune cells, showing their potential as an immunotherapeutic agent.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Analytical
Jihun Jang, Jinwoo Kim, Hak Jong Lee, Jin Ho Chang
Summary: The TRUS-PA probe, combining transrectal ultrasound and photoacoustic imaging, is able to visualize morphological changes and microvasculature distribution in the prostate, improving the quality of photoacoustic images.
Article
Acoustics
Haemin Kim, Hohyeon Lee, Hyuncheol Kim, Jin Ho Chang
Summary: Photoacoustic imaging has been in the spotlight for its ability to provide optical contrast images of physiological information and deep imaging depth, but its sensitivity is limited by nontargeted signals and clutter artifacts. Researchers proposed a method to eliminate nontargeted signals using a dual-modal ultrasound-photoacoustic contrast agent and demonstrated improved visualization of target areas in photoacoustic images.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Review
Chemistry, Analytical
Jin-Ho Sung, Jin-Ho Chang
Summary: Intravascular ultrasound (IVUS) is a valuable imaging modality for diagnosing atherosclerosis, providing useful clinical information by offering cross-sectional vascular images. Recent advancements in mechanically rotating IVUS transducers, particularly those utilizing piezoelectric ceramics or single crystals, have greatly improved the accuracy of diagnosis.
Article
Pharmacology & Pharmacy
Daehyun Kim, Wonkook Han, Jin Ho Chang, Hak Jong Lee
Summary: The development of Porphyrin-Micelle (PM) through the synthesis of porphyrin and PEG-3.5k has shown superior signal in cancer diagnosis and increased binding affinity with prostate-specific membrane antigen PSMA.
Article
Computer Science, Information Systems
Jinwoo Kim, Haemin Kim, Jin Ho Chang
Proceedings Paper
Optics
Gyuwon Jo, Haemin Kim, Jin Ho Chang
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2019
(2019)