Article
Oncology
Elisabeth Werner Ronnerman, Daniella Pettersson, Szilard Nemes, Pernilla Dahm-Kahler, Aniko Kovacs, Per Karlsson, Toshima Z. Parris, Khalil Helou
Summary: Ovarian cancer is the leading cause of gynecological cancer-related death. This study identified Trefoil factor gene family members (TFF1, TFF2, and TFF3) as novel histotype-specific biomarkers for mucinous carcinomas (MC) through RNA sequencing analysis. Immunohistochemistry evaluation confirmed significantly elevated expression levels of TFF proteins in MC samples, suggesting their pivotal role in tumor initiation and progression for the MC histotype.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy, Charulochana Subramony, Marcelo Sakiyama, Logan Fair, Teja Poosarla, Xinchun Zhou, W. Shannon Orr, Christopher Lahr, Sejong Bae, Sameer Al Diffalha, Upender Manne, Christian R. Gomez
Summary: The study revealed low expression of TFF3 in colorectal cancer, which is associated with tumor progression. Omics data and immunohistochemical analysis findings were consistent in confirming the lower expression of TFF3 in CRC.
Article
Biochemistry & Molecular Biology
Karolina Rogulska, Iwona Wojciechowska-Koszko, Barbara Krasnodebska-Szponder, Pawel Kwiatkowski, Paulina Roszkowska, Barbara Dolegowska, Karolina Luczkowska, Boguslaw Machalinski, Danuta Kosik-Bogacka
Summary: This study aimed to determine the diagnostic value of TFF3 in allogeneic kidney transplant patients and investigate the influence of diagnostic methods, biological materials, and post-transplantation time on its levels. The study found that TFF3 levels were associated with creatinine and eGFR levels, and can serve as a biomarker for monitoring renal transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sang-Mi Kim, Hyun-Seung Lee, Min-Ji Kim, Hyung-Doo Park, Soo-Youn Lee
Summary: The study evaluated the diagnostic value of nine serum biomarkers for vancomycin-induced kidney injury (VIKI) and found that TFF3, cystatin C, TNF-R1, and osteopontin had excellent diagnostic value for VIKI and showed a strong negative correlation with estimated glomerular filtration rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zeynep Pinar Keles Yucel, Beral Afacan, Harika Atmaca Ilhan, Timur Kose, Gulnur Emingil
Summary: This study found elevated levels of TFF-1, TFF-3, and IL-1 beta in periodontitis patients compared to healthy controls and gingivitis group across GCF, saliva, and serum samples. These findings suggest the involvement of these peptides in host response during periodontal tissue destruction.
Article
Oncology
Andrea Cruz, Carla M. Carvalho, Alexandra Cunha, Anais Crespo, Agueda Iglesias, Laura Garcia-Nimo, Paulo P. Freitas, Joaquin Cubiella
Summary: The study aimed to analyze the diagnostic value of six biomarkers in stool samples of patients with CRC, advanced adenomas, other lesions, and healthy individuals. Results showed that Hb and M2-PK levels were increased in CRC patients compared to controls, suggesting a potential as fecal diagnostic biomarkers for CRC detection.
Review
Biotechnology & Applied Microbiology
Chen-Xing Zhang, Chu-Tian Wu, Lin Xiao, Shao-Hui Tang
Summary: TFF3 shows promise as a biomarker for gastric cancer, with its expression potentially playing a role in invasion, metastasis, and differentiation of the disease.
Review
Biochemistry & Molecular Biology
Heather L. Rossi, Jorge F. Ortiz-Carpena, Devon Tucker, Andrew E. Vaughan, Nilam S. Mangalmurti, Noam A. Cohen, De'Broski R. Herbert
Summary: This review discusses the important role of TFF family members in healthy and diseased airways. TFF peptides maintain and restore homeostasis in the airways through their regulation of the mucous layer, cell motility, cell differentiation, and immune function. Differences in TFF member tracks between humans and mice pose a challenge for research. New evidence suggests that TFF proteins interact with receptor binding partners in mediating biological effects in mouse models of repair and infection. TFF peptides may be reasonable therapeutic targets in the treatment of airway diseases.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Monika Kamianowska, Agnieszka Rybi-Szuminska, Aleksandra Kamianowska, Mateusz Maciejczyk, Katarzyna Solomianko, Alicja Koput, Anna Wasilewska
Summary: This study aimed to assess the urinary concentration of trefoil factor 3 (TFF3) in healthy term and stable preterm neonates. The results showed higher TFF3/cr. values in preterm neonates compared to term neonates, and male term neonates had increased urinary TFF3 excretion. These findings have important implications for the diagnosis in neonatology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Ziyang Lin, Xiaofen Wan, Tao Zhang, Hongyan Huo, Xiaoyu Zhang, Kunping Li, Weijian Bei, Jiao Guo, Yiqi Yang
Summary: TFF3 has various biological functions in the kidney, particularly playing an important role in chronic kidney disease. Research suggests that the levels of TFF3 in urine and serum significantly increase with the progression of CKD.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Hong-Yong Cui, Shi-Jie Wang, Fei Song, Xu Cheng, Gang Nan, Yu Zhao, Mei-Rui Qian, Xi Chen, Jia-Yue Li, Fen-Ling Liu, Yu-Meng Zhu, Ruo-Fei Tian, Bin Wang, Bin Wu, Yang Zhang, Xiu-Xuan Sun, Ting Guo, Xiang-Min Yang, Hai Zhang, Ling Li, Jing Xu, Hui-Jie Bian, Jian-Li Jiang, Zhi-Nan Chen
Summary: Major gaps in understanding the molecular mechanisms of colorectal cancer progression and mucosal repair have hindered therapeutic development for gastrointestinal disorders. TFF3 plays a crucial role in CRC progression and mucosal repair, with upregulated TFF3 predicting worse survival rates in CRC patients. The interaction between TFF3 and CD147 enhances CRC progression by activating STAT3 and PTGS2, leading to increased migration, proliferation, and invasion of cancer cells.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Microbiology
Olabisi Oluwabukola Coker, Changan Liu, William Ka Kei Wu, Sunny Hei Wong, Wei Jia, Joseph J. Y. Sung, Jun Yu
Summary: This study identifies gut microbiota-associated metabolites and their role in colorectal carcinogenesis. Additionally, the integrated analysis of metabolomics and metagenomics profiles reveals the perturbation of gut metabolites and their association with gut microbiota along colorectal carcinogenesis. Fecal metabolites show potential for non-invasive diagnosis of colorectal neoplasia.
Article
Cell Biology
Lisanne J. H. Smits, Elisa Vink-Borger, Gesina van Lijnschoten, Isabelle Focke-Snieders, Rachel S. van der Post, Jurriaan B. Tuynman, Nicole C. T. van Grieken, Iris D. Nagtegaal
Summary: This study evaluated the interobserver variability between individual pathologists and a panel of pathologists in assessing advanced colorectal neoplasms, finding discrepancies in the assessment of adenomas with high-grade dysplasia and early colorectal carcinomas, which may impact treatment choices. Additional stains, education, and intercollegial consultation may help decrease this variability.
Article
Gastroenterology & Hepatology
Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Summary: This study evaluated the associations between gastric cancer family history and colorectal cancer risk, as well as between colorectal cancer family history and gastric adenoma risk. The results showed that gastric cancer family history was associated with an increased risk of gastric cancer, while colorectal cancer family history was not associated with the risk of gastric cancer or gastric adenoma. However, individuals with family histories of both gastric cancer and colorectal cancer had a higher risk of gastric adenoma. The study suggests that family histories of gastric cancer and colorectal cancer may affect each other's neoplastic lesion risk.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: Obesity is on the rise globally, with high-fat diets playing a significant role in energy metabolism balance. The research suggests that TFF2 is specifically induced by high-fat diets and may regulate lipid metabolism pathways to contribute to obesity development.