Article
Oncology
Karine Brochu-Gaudreau, Martine Charbonneau, Kelly Harper, Claire M. Dubois
Summary: Transforming growth factor beta (TGF beta) has a paradoxical role in cancer, initially inhibiting and then promoting its progression. This study reveals that hypoxia induces the pro-invasive arm of TGF beta signaling through selective activation of SMAD3 and its interaction with SMAD-Anchor for Receptor Activation (SARA). SMAD3 selectively increases the expression of ITGB2 and VIM, genes associated with hypoxia-induced cell invasion, tumor progression, and metastasis. Selective inhibition of the SMAD3 signaling pathway shows significant benefits in preventing tumor progression compared to global TGF beta inhibition.
Article
Health Care Sciences & Services
Florian G. Klein, Charlene Granier, Yuling Zhao, Qi Pan, Zhichao Tong, Jurgen E. Gschwend, Per Sonne Holm, Roman Nawroth
Summary: The study confirmed that the combination therapy of CDK4/6 inhibitor Palbociclib with PARP inhibitor Talazoparib effectively enhances bladder cancer treatment efficacy, with RB being a molecular biomarker of response to this treatment regimen.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Rocio Jimenez-Guerrero, Alejandro Belmonte-Fernandez, M. Luz Flores, Monica Gonzalez-Moreno, Begona Perez-Valderrama, Francisco Romero, Miguel A. Japon, Carmen Saez
Summary: This study reveals the role of the Wnt/β-catenin pathway in paclitaxel resistance in bladder cancer cells with CSC-like properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Teixeira Pinto, Ana Sofia Ribeiro, Ines Conde, Rita Carvalho, Joana Paredes
Summary: The high plasticity of CSCs allows them to differentiate and proliferate effectively in immunocompromised mice, making them highly tumorigenic even in small numbers. The CAM-LDA assay established here is a rapid and reproducible model for studying tumor specificities, particularly the ability of a small population of CSCs to form tumors. This model provides a convenient and accessible tool for studying CSC prevalence and function, with histologically comparable results to traditional mice xenograft models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yagmur Azbazdar, Mustafa Karabicici, Esra Erdal, Gunes Ozhan
Summary: Wnt signaling pathway plays a crucial role in physiological activities and has significant implications in cancer development and progression. By regulating plasma membrane composition and lipid organization, Wnt signaling can be activated or inhibited, leading to the development of more targeted anticancer drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xin Yu, Wenge Li, Yanjun Feng, Zhijie Gao, Qi Wu, Yue Xia
Summary: Bladder cancer is the second most common urological malignancy and contributes significantly to cancer-related deaths worldwide. The hedgehog signaling pathway plays a role in the onset and spread of various cancers, including bladder cancer. However, there is still limited understanding of the function of HhS in the molecular landscape of bladder cancer.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Francesca Damiani Victorelli, Livia Salvati Manni, Stefania Biffi, Barbara Bortot, Hilde Harb Buzza, Viviane Lutz-Bueno, Stephan Handschin, Giovana Calixto, Sergio Murgia, Marlus Chorilli, Raffaele Mezzenga
Summary: In this study, a vaginal drug administration platform for cervical cancer treatment was developed using cubosomes to deliver curcumin. The efficiency of the system was assessed using the CAM model and various characterization techniques. The results showed promising potential for the use of curcumin-loaded cubosomes in cervical cancer treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Endocrinology & Metabolism
Xing Wei, Martine P. Roudier, Oh-Joon Kwon, Justin D. Lee, Kevin Kong, Ruth Dumpit, Lawrence True, Colm Morrissey, Daniel W. Lin, Peter S. Nelson, Li Xin
Summary: Our study reveals the importance of stroma-derived Wnt ligands in prostate development and homeostasis. We found that Wnt ligands have distinct spatial distribution in the prostatic glands and Wnt signaling components are highly expressed in the stromal compartment of human prostate cancer. Blocking stromal Wnt secretion attenuates prostate epithelial proliferation and regeneration.
Article
Pathology
Li-Juan Jiang, Song-Bin Guo, Zhong-Ying Huang, Xin-Ling Li, Xiao-Han Jin, Wei-Juan Huang, Xiao-Peng Tian
Summary: This study investigated the role of PHB in bladder carcinoma aggressiveness and found that it promotes invasion by binding with beta-catenin to prevent its degradation. Patients with PHB overexpression should receive more aggressive adjuvant anticancer therapies after surgery.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Jiun-Long Wang, Ying-Wei Lan, Yi-Ting Tsai, Ying-Cheng Chen, Theresa Staniczek, Yung-An Tsou, Chih-Ching Yen, Chuan-Mu Chen
Summary: The combination therapy of metformin and pemetrexed demonstrated antiproliferative effects by inducing cell cycle arrest in the S phase and exhibited antiangiogenic effects by inhibiting vascular structure formation. The research suggests that this combination treatment could be beneficial for clinical lung cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Qianyi DU, Min Yi, Hongyi LI, Jiayi Liu, Caizhong Guan, Yaguang Zeng, Honglian Xiong, Xuehua Wang, Junping Zhong, Yanxiong Wu, Haishu Tan, Dingan Han, Mingyi Wang
Summary: Multi-level optical angiography (MOA) method is proposed for photodynamic therapy (PDT) to enhance capillaries and image vessels at different levels by measuring the signal frequency shift associated with red blood cell motion. This method can provide more accurate quantitative information regarding various vascular parameters.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemistry & Molecular Biology
Liu-Ya Tang, Marie Spezia, Ting Chen, Jee-Hye Shin, Feng Wang, Frank Stappenbeck, Andres M. Lebensohn, Farhad Parhami, Ying E. Zhang
Summary: The study revealed that oxysterols Oxy186 and Oxy210 can inhibit proliferation of NSCLC cells, with Oxy186 exhibiting potent inhibition of tumor growth. The mechanism of action involves inhibiting the WNT/beta-catenin signaling pathway.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mandy Berndt-Paetz, Shanfu Han, Annett Weimann, Annabell Reinhold, Sandra Nuernberger, Jochen Neuhaus
Summary: Three-dimensional tumor models, such as organoids, are valuable tools for bladder cancer research as they accurately mimic the structure and characteristics of solid tumors. These models can be used for functional studies and development of anti-cancer drugs.
Review
Cell Biology
Mia C. Borlongan, Hongbin Wang
Summary: Tumorigenic cancer stem cells (CSCs) are a subset of cells within tumors that have distinct genetic and phenotypic profiles and signaling pathways compared to other tumor cells. Targeting the unique self-renewal and differentiation properties of CSCs could revolutionize cancer therapy. Understanding the signaling mechanisms of CSCs will improve our knowledge of cancer pathology and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Fan Yang, Zhuifeng Guo, Chang He, Liang Qing, Hang Wang, Jiawen Wu, Xuwei Lu
Summary: The study revealed that cancer-associated fibroblasts (CAFs) from bladder cancer tissues promote cell proliferation and invasion of bladder cancer cells through a Wnt/IL1 beta signaling feedback mechanism. Inhibition of the Wnt signaling pathway may provide a promising target to block the interaction between CAFs and bladder cancer cells.
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Letter
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Article
Urology & Nephrology
Mykyta Kachanov, Lars Budaeus, Dirk Beyersdorff, Pierre I. Karakiewicz, Zhe Tian, Fabian Falkenbach, Derya Tilki, Tobias Maurer, Guido Sauter, Markus Graefen, Sami-Ramzi Leyh-Bannurah
Summary: Combining targeted biopsy alone and combined with systematic biopsy, along with quantitative Gleason grading of biopsy specimen, accurately detects low levels of GP 4 and helps identify patients suitable for active surveillance.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Oncology
Mohamed E. Elsesy, Su Jung Oh-Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak-Rothkamm, Malik Alawi, Christian Mueller, Ulrich Schueller, Tobias Maurer, Gunhild von Amsberg, Cordula Petersen, Kai Rothkamm, Wael Y. Mansour
Summary: This study provides preclinical models for castration-resistant prostate cancer (CRPC) that can predict homologous recombination repair (HRR) defects and the sensitivity to olaparib and cisplatin. These models recapitulate the features of primary tumors, enabling individualized drug screening for tailored therapy recommendations.
MOLECULAR ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Urs J. Muehlematter, Lilit Schweiger, Daniela A. Ferraro, Thomas Hermanns, Tobias Maurer, Matthias M. Heck, Niels J. Rupp, Matthias Eiber, Isabel Rauscher, Irene A. Burger
Summary: This study developed and evaluated a LNI prediction model using [Ga-68]Ga-PSMA-11 PET, showing improved prediction in intermediate to high-risk PCa patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Urology & Nephrology
Robert Seifert, Louise Emmett, Steven P. Rowe, Ken Herrmann, Boris Hadaschik, Jeremie Calais, Frederik L. Giesel, Robert Reiter, Tobias Maurer, Matthias Heck, Andrei Gafita, Michael J. Morris, Stefano Fanti, Wolfgang A. Weber, Thomas A. Hope, Michael S. Hofman, Wolfgang Peter Fendler, Matthias Eiber
Summary: This study proposes the PROMISE V2 framework for standardized interpretation and reporting of PSMA-PET findings, aiming to improve communication between imaging experts and uro-oncologists. The framework integrates an updated miTNM system, improved assessment of local disease, and a slightly modified PSMA-expression score for clinical routine and research.
Article
Oncology
Lukas Lunger, Lisa Steinhelfer, Philipp Korn, Matthias Eiber, Tobias Maurer, Jakob Buechler, Thomas Horn, Jurgen E. Gschwend, Matthias M. Heck
Summary: This study investigated the use of prostate-specific membrane antigen (PSMA)-radioguided surgery (RGS) to remove locoregional lymph node metastases (LNMs) identified on preoperative PSMA positron emission tomography (PET) during open radical prostatectomy (RP) with extended pelvic lymph node dissection (ePLND). The results showed a high success rate (94%) of resecting PSMA-positive LNMs using RGS, with 40% of LNMs located outside the ePLND template. Patients with a lower metastatic burden on preoperative PSMA PET had better postoperative outcomes. The study has limitations including a retrospective analysis and a small sample size.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Ambrosini, Fabian Falkenbach, Lars Budaeus, Thomas Steuber, Markus Graefen, Daniel Koehler, Sophie Knipper, Tobias Maurer
Summary: This study compares the oncological and surgical outcomes of open and robot-assisted salvage prostate-specific membrane antigen-radioguided surgery (PSMA-RGS) in patients with recurrent prostate cancer. The results show comparable oncological outcomes between the two approaches.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Fabian Falkenbach, Francesca Ambrosini, Pierre Tennstedt, Matthias Eiber, Matthias M. Heck, Felix Preisser, Markus Graefen, Lars Budaeus, Daniel Koehler, Sophie Knipper, Tobias Maurer
Summary: This study found that both BCR risk groups and PSA kinetics are not predictive factors for the success of PSMA-RGS performed at low absolute PSA values. Additionally, indolent low-risk BCR is rarely treated with PSMA-RGS.
Article
Urology & Nephrology
Gisa Mehring, Derya Tilki, Hans Heinzer, Thomas Steuber, Randi M. Pose, Imke Thederan, Lars Budaeus, Georg Salomon, Alexander Haese, Uwe Michl, Tobias Maurer, Hartwig Huland, Markus Graefen, Hendrik Isbarn
Summary: Prostate cancer detection is usually achieved by PSA measurement and further diagnostics. However, some men might harbor significant PCa at a younger age. This study evaluated the histopathological results of men treated with RP in their 40s.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Elena Herms, Gregor Weirich, Tobias Maurer, Stefan Wagenpfeil, Stephanie Preuss, Andreas Sauter, Matthias Heck, Anita Gaertner, Katharina Hauner, Michael Autenrieth, Hubert P. Kubler, Konstantin Holzapfel, Ulrike Schwarz-Boeger, Uwe Heemann, Julia Slotta-Huspenina, Konrad Friedrich Stock
Summary: This study examines the benefits of using combined contrast-enhanced ultrasound (CEUS) and CT/MRI evaluation in diagnosing and monitoring renal cystic lesions. The results show that the CEUS-Bosniak classification is an essential tool in clinical practice for differentiating and monitoring renal cysts, and it enhances diagnostic work-up and patient care.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Stefano Fanti, Alberto Briganti, Louise Emmett, Karim Fizazi, Silke Gillessen, Karolien Goffin, Boris A. Hadaschik, Ken Herrmann, Jolanta Kunikowska, Tobias Maurer, Steven MacLennan, Nicolas Mottet, Declan G. Murphy, Daniela E. Oprea-Lager, Joe M. O'Sullivan, Wim J. G. Oyen, Olivier Rouviere, Oliver Sartor, Arnulf Stenzl, Hendrik Van Poppel, Jochen Walz, Wim Witjes, Anders Bjartell
Summary: The use and potential of PSMA PET/CT in prostate cancer treatment and management were assessed and achieved consensus among a panel of experts, particularly in utilizing PSMA PET/CT for patient selection and guiding [177Lu]Lu-PSMA therapy.
EUROPEAN UROLOGY ONCOLOGY
(2022)