Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Medicine, Research & Experimental
Shanchao Wang, Zeyan Zhang, Qianfu Gao
Summary: In this study, it was found that cancer cell-derived extracellular vesicles (EVs) promoted colorectal cancer (CRC) progression by delivering miR-25, which targeted SIRT6. SIRT6, in turn, inhibited NRP-1 through downregulation of Lin28b. Tumor-bearing nude mouse experiments confirmed that EVs transferred miR-25 to facilitate tumor formation and metastasis by inhibiting SIRT6.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Shirley James, Jayasekharan S. Aparna, Anu Babu, Aswathy Mary Paul, Manendra Babu Lankadasari, Subha R. Athira, Sreesha S. Kumar, Yadu Vijayan, Narayanan N. Namitha, Sabira Mohammed, Girijadevi Reshmi, Kuzhuvelil B. Harikumar
Summary: Studies have shown that cardamonin possesses anti-inflammatory properties and potential anti-colorectal cancer effects in both in vitro and in vivo experiments. It can reduce the expression of inflammatory molecules and inhibit tumor formation by modulating miRNA expression.
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Summary: miRNAs play a significant role in CRC by influencing the expression and activity of CRC-related pathways and interacting with long non-coding RNAs. Levels of miRNAs can be used to distinguish CRC patients from healthy controls. Despite evaluation of therapeutic application of miRNAs in CRC in animal models, it has not been verified in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Review
Medicine, Research & Experimental
Ning Zhang, Xianyu Hu, Yinan Du, Juan Du
Summary: Colorectal cancer is the third most common and fourth most deadly cancer worldwide, with microRNAs playing essential roles in CRC and serving as potential targets for therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Genetics & Heredity
Shengyong Zhai, Xiaoling Li, Yan Wu, Xiaoli Shi, Binbin Ji, Chun Qiu
Summary: This study proposes a new method, BNNRMDA, for identifying potential microRNA biomarkers for colon cancer and colorectal cancer. The method combines disease semantic similarity, Gaussian Association Profile Kernel (GAPK) similarity, microRNA function similarity, and a regularization model. Experimental results show that BNNRMDA has strong performance in microRNA-disease association identification and discovers several potential biomarkers.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Wei Liu, Longan Ma, Jie Zhang
Summary: The study identified that miR-934 regulates colorectal cancer cell proliferation by targeting DDK2 in colorectal cancer cells. Knockdown of DDK2 can reverse the inhibitory effects of miR-934, suggesting miR-934 may serve as a potential biomarker for patients with colorectal cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Cell Biology
Crescenzo Massaro, Elham Safadeh, Giulia Sgueglia, Hendrik G. Stunnenberg, Lucia Altucci, Carmela Dell'Aversana
Summary: Colorectal cancer (CRC) remains the third leading cause of cancer death globally, with patients often developing drug resistance and disease recurrence. Key studies have identified the crucial role of microRNAs (miRNAs) in cancer progression and drug resistance, suggesting their potential as future therapeutic targets for overcoming resistance in CRC treatment.
Article
Gastroenterology & Hepatology
Lei Sun, Arabella Wan, Zhuolong Zhou, Dongshi Chen, Heng Liang, Chuwei Liu, Shijia Yan, Yi Niu, Ziyou Lin, Siyue Zhan, Shanfeng Wang, Xianzhang Bu, Weiling He, Xiongbin Lu, Anlong Xu, Guohui Wan
Summary: The study identified an RNA-binding protein RALY as a critical regulator in colorectal cancer metabolism, promoting the post-transcriptional processing of miRNAs that downregulate metabolism-associated genes and reprogram mitochondrial metabolism in cancer cells. Increased levels of RALY were associated with poor prognosis in CRC patients expressing low levels of mitochondrion-associated genes, and this effect was facilitated by N6-methyladenosine switch under reactive oxygen species stress. Inhibition of m6A methylation abolished RALY recognition of pri-miRNAs, leading to inhibition of colorectal tumor growth and progression both in vivo and in organoid models.
Editorial Material
Medicine, Research & Experimental
Kai Jiang, Haiyan Chen, Kefeng Ding
Summary: In this commentary, new observations suggest that angiopoietin-like protein 1 (ANGPTL1) attenuates cancer metastasis and stemness in colorectal cancer through the Forkhead box O-3a (Foxo3a)-SRY-related HMG-box-2 (Sox2) axis. Although ANGPTL1 plays a critical role in cancer progression and metastasis, the underlying mechanisms are still controversial. The possible mechanisms of ANGPTL1 inhibiting colorectal cancer liver metastasis are integrated, and the regulation of ANGPTL1 on the Foxo3a-Sox2 pathway is discussed. However, further research is needed for ANGPTL1 to become an effective treatment strategy in the clinic.
Review
Biochemistry & Molecular Biology
Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Imilia Ismail, Learn-Han Lee, Nurul Syakima Ab Mutalib
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, and microRNAs play a significant role in its occurrence and progression. However, the methylation profiles of microRNAs in colorectal cancer patients are still unknown. Methylation is an important factor in cancer detection, and this review aims to provide insight into the current understanding of microRNA methylation in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Triet M. Bui, Veronika Butin-Israeli, Hannah L. Wiesolek, Meredith Zhou, Jake F. Rehring, Lisa Wiesmueller, Jennifer D. Wu, Guang-Yu Yang, Stephen B. Hanauer, Julien A. Sebag, Ronen Sumagin
Summary: In this study, the researchers aimed to investigate the impact of neutrophils on DNA double-strand break (DSB)-repair responses in inflamed colon and their effects on colorectal cancer (CRC) progression and the sensitivity/resistance to DNA-repair targeted therapy. They found that neutrophils play a dual role in cancer cells, influencing the DNA damage landscape and resolution of DSBs. Neutrophils were shown to promote homologous recombination deficiency in low-grade CRC but induce non-homologous end-joining in advanced CRC, leading to different therapeutic targets for these two CRC phenotypes induced by neutrophils.
Review
Biochemistry & Molecular Biology
Daniela A. R. Santos, Cristiana Gaiteiro, Marlene Santos, Lucio Santos, Mario Dinis-Ribeiro, Luis Lima
Summary: Colorectal cancer (CRC) is the third most common cancer globally. Early detection is crucial for better prognosis and increased survival rate. MicroRNA biomarkers have emerged as a powerful tool for CRC screening, as they are highly expressed in CRC patients and easily detectable. This review evaluates the available data on microRNAs as promising biomarkers for early CRC screening, discusses their advantages, disadvantages, and optimal study characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
Summary: Colorectal cancer (CRC) ranks as the third most common cancer worldwide, emphasizing the significance of early detection. Screening through fecal occult blood tests has shown to reduce CRC incidence and mortality, however, low participation rates and false positives are key challenges. Recent research has focused on new fecal tests, biomarkers, and liquid biopsy methods to enhance accuracy and participation in CRC screening.
Review
Biochemistry & Molecular Biology
Yarely M. Salinas-Vera, Dolores Gallardo-Rincon, Erika Ruiz-Garcia, Macrina B. Silva-Cazares, Carmen Sol de la Pena-Cruz, Cesar Lopez-Camarillo
Summary: Endometrial cancer, the most frequent neoplasia from the corpus uteri, is a leading cause of death in women worldwide. Chemotherapy's clinical effectiveness is unstable, calling for novel molecular targeted therapies that can improve the success rates of endometrial cancer treatment. During tumor growth, cancer cells adapt to decreased oxygen availability by upregulating hypoxia-inducible factors, leading to enhanced cell survival, invasiveness, proliferation, and resistance to chemotherapy. Hypoxia-inducible factor 1 alpha (HIF-1 alpha), which is aberrantly overexpressed in various solid tumors, has been considered an important therapeutic target. MicroRNAs also play a significant role in regulating the protein-encoding genes involved in the hypoxia response in endometrial cancer.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rodolfo Gamaliel Avila-Bonilla, Jorge Antonio Velazquez-Guzman, Eimy Itzel Reyes-Zepeda, Jorge Luis Gutierrez-Avila, Cesar A. Reyes-Lopez, Alondra Cisneros-Sarabia, Emma Saavedra, Angel Lopez-Sandoval, Esther Ramirez-Moreno, Cesar Lopez-Camarillo, Laurence A. Marchat
Summary: Protein-protein interactions are important for predicting the function of target proteins and the ability of drugs to affect biological systems. Computational analysis of polyadenylation factors in protozoan parasites and the human host identified key proteins and potential targets for pathogen control. Experimental validation confirmed the relationships among these proteins and suggested a connection between RNA biology and metabolism.
BIOSCIENCE REPORTS
(2023)
Editorial Material
Genetics & Heredity
Angeles Carlos-Reyes, Susana Romero-Garcia, Cesar Lopez-Camarillo, Guillermo Barreto, Heriberto Prado-Garcia
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Silvia Ivonne Arzola-Rodriguez, Laila-Nayzzel Munoz-Castellanos, Cesar Lopez-Camarillo, Erika Salas
Summary: Polyphenols are secondary metabolites from plants with natural antioxidant capacity and biological activities. Due to their mostly polar character, they have low solubility in less polar environments or hydrophobic matrices. However, by functionalizing them through chemical or enzymatic lipophilization, phenolipids can be synthesized. These amphipilic molecules possess a natural phenolic core and an attached aliphatic motif, allowing them to interact with various systems and potentially be used in processed foods, as drug carriers, antimicrobial agents, antioxidants in the cosmetic industry, and even in the treatment of degenerative diseases related to oxidative stress.
Review
Oncology
Alma Jaqueline Heredia-Mendez, Gricelda Sanchez-Sanchez, Cesar Lopez-Camarillo
Summary: During the last century, 2D cell cultures have been commonly used to study cancer biology, drug discovery, genomics, and gene expression regulation. However, this approach has limitations in accurately reproducing the tumor microenvironment and cellular processes. To overcome these limitations, 3D cell cultures have been implemented to better mimic the biological and molecular features of tumors. This review discusses the application of different types of 3D cell culture models to characterize the epigenetic changes in cancer cells, particularly DNA methylation patterns, and the impact of microenvironmental factors on these changes.
Editorial Material
Cell Biology
Macrina B. Silva-Cazares, Carlos Perez-Plasencia, Cesar Lopez-Camarillo
Article
Oncology
Rafael Vazquez-Romo, Oliver Millan-Catalan, Erika Ruiz-Garcia, Antonio. D. D. Martinez-Gutierrez, Alberto Alvarado-Miranda, Alma. D. D. Campos-Parra, Cesar Lopez-Camarillo, Nadia Jacobo-Herrera, Eduardo Lopez-Urrutia, Mariano Guardado-Estrada, David Cantu de Leon, Carlos Perez-Plasencia
Summary: This study sequenced the DNA of 40 Mexican-mestizo metastatic breast cancer patients and identified 22 variants, including 9 novel ones. The study found a significantly high proportion of variations in ARID1A, and the presence of variants in ARID1A, BRCA1, BRCA2, or FANCA genes was associated with worse survival outcomes. The findings suggest routine screening for ARID1A and BRCA1/2 variants in Mexican-mestizo breast cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biology
Edgar Yebran Villegas-Vazquez, Laura Itzel Quintas-Granados, Hernan Cortes, Manuel Gonzalez-Del Carmen, Gerardo Leyva-Gomez, Miguel Rodriguez-Morales, Lilia Patricia Bustamante-Montes, Daniela Silva-Adaya, Carlos Perez-Plasencia, Nadia Jacobo-Herrera, Octavio Daniel Reyes-Hernandez, Gabriela Figueroa-Gonzalez
Summary: Lithium, an anti-cancer agent, shows potential in inducing apoptosis, autophagy, and inhibiting tumor growth. It also plays a role in tumor regulation and synergizes with standard cancer therapies. Additionally, lithium has neuroprotective effects and enhances anti-tumor activities in nano-sized form. However, its therapeutic activities depend on various factors. This review emphasizes the importance of repurposing lithium as a therapeutic agent and highlights its molecular mechanisms.
Article
Oncology
Estefania Contreras-Sanzon, Angeles Carlos-Reyes, Monica Sierra-Martinez, Gustavo Acosta-Altamirano, Cesar Luna-Rivero, David Nunez-Corona, Alejandra Paola Garcia-Hernandez, Eloisa Ibarra-Sierra, Horacio Vidrio-Morgado, Maria Elizbeth Alvarez-Sanchez, Laurence A. Marchat, Cesar Lopez-Camarillo
Summary: This study evaluated the expression of VM-associated microRNAs in tumors of metastatic breast cancer patients and explored their potential therapeutic value in disease progression. It was found that certain microRNAs regulating VM and metastasis were downregulated in primary tumors of patients with metastatic disease, and these regulatory factors had predictive value in patient survival. Furthermore, in vitro experiments demonstrated that miR-145 mimics could inhibit the development of VM in metastatic breast cancer cells.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Engineering, Chemical
Lucero Evelia Acuna-Aguilar, Alain Salvador Conejo-Davila, Mario Miki-Yoshida, Olga N. Hernandez-de la Cruz, Gricelda Sanchez-Sanchez, Cesar Lopez-Camarillo, Joan Sebastian Salas-Leiva, Erasto Armando Zaragoza-Contreras, Reyna Reyes-Martinez, Erasmo Orrantia-Borunda
Summary: In this study, nanodiamonds functionalized with metformin (ND-MET) were synthesized and characterized. The cytotoxicity of ND-MET on breast and ovarian cancer cells was evaluated. The results showed that ND-MET exhibited significant toxicity towards cancer cells.
Article
Oncology
Mariana Avendano-Felix, Maribel Aguilar-Medina, Jose Geovanni Romero-Quintana, Alfredo Ayala-Ham, Adriana S. Beltran, Jose F. Olivares-Quintero, Cesar Lopez-Camarillo, Carlos Perez-Plasencia, Mercedes Bermudez, Erik Lizarraga-Verdugo, Jorge Lopez-Gutierrez, Guzman Sanchez-Schmitz, Rosalio Ramos-Payan
Summary: This study evaluated the role of SOX9 in colorectal cancer stem cells (CRC-CSCs). The results showed that SOX9 promotes the stemness properties of CRC-CSCs by regulating stem cell markers, increasing sphere formation, and maintaining CSCs surface markers. Therefore, SOX9 may serve as a potential therapeutic target for CRC stem cells.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Paola Zepeda-Enriquez, Macrina B. Silva-Cazares, Cesar Lopez-Camarillo
Summary: Circular RNAs play important roles in the development and progression of TNBC and have the potential to serve as prognostic biomarkers and novel therapeutic targets. In-depth understanding of circRNA biogenesis, functions, and their roles in metastasis and therapy responses could provide valuable guidance in advancing the treatment of TNBC.
Review
Biochemistry & Molecular Biology
David Nunez-Corona, Estefania Contreras-Sanzon, Jonathan Puente-Rivera, Rodrigo Arreola, Minerva Camacho-Nuez, Jose Cruz Santiago, Edgar Antonio Estrella-Parra, Julio Cesar Torres-Romero, Cesar Lopez-Camarillo, Maria Elizbeth Alvarez-Sanchez
Summary: Testicular cancer is the most common tumor in males aged 15 to 35, with a high number of new cases and deaths each year. Non-coding RNAs (ncRNAs) play a crucial role in the regulation of cellular processes and pathologies, including testicular cancer. Epigenetic modifications, such as histone modifications and DNA methylation, along with microRNA (miRNA) regulation, are also associated with testicular tumor progression and treatment response. This review focuses on the latest discoveries in the epigenetic aspect of testicular cancer, particularly the involvement of proteins and ncRNAs like miRNAs and lncRNA, highlighting their relevance in pathogenesis and potential for prognostic evaluation and targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
