Why clinical trial outcomes fail to translate into benefits for patients

Quality of Life, Overall Survival, and Costs of Cancer Drugs Approved Based on Surrogate Endpoints

(2017) Tracy Rupp et al.   JAMA Internal Medicine

Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data

(2016) Carl J Heneghan et al.   HEALTH TECHNOLOGY ASSESSMENT

A new classification of spin in systematic reviews and meta-analyses was developed and ranked according to the severity

(2016) Amélie Yavchitz et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies

(2016) Matthew J. Page et al.   PLoS One

A systematic review of randomised controlled trials in rheumatoid arthritis: the reporting and handling of missing data in composite outcomes

(2016) Fowzia Ibrahim et al.   Trials

Feasibility study to examine discrepancy rates in prespecified and reported outcomes in articles submitted toThe BMJ

(2016) Jennifer Weston et al.   BMJ Open

Conflicts of interest and spin in reviews of psychological therapies: a systematic review

(2016) Klaus Lieb et al.   BMJ Open

PRISMA harms checklist: improving harms reporting in systematic reviews

(2016) Liliane Zorzela et al.   BMJ-British Medical Journal

Assessment of Adverse Events in Protocols, Clinical Study Reports, and Published Papers of Trials of Orlistat: A Document Analysis

(2016) Jeppe Bennekou Schroll et al.   PLOS MEDICINE

Reporting of Adverse Events in Published and Unpublished Studies of Health Care Interventions: A Systematic Review

(2016) Su Golder et al.   PLOS MEDICINE

PRISMA harms checklist: improving harms reporting in systematic reviews

(2016) Liliane Zorzela et al.   BMJ-British Medical Journal

Surrogate outcome markers in research and clinical practice

(2016) Scott Twaddell   Australian Prescriber

Dementia priority setting partnership with the James Lind Alliance: using patient and public involvement and the evidence base to inform the research agenda

(2015) Sarah Kelly et al.   AGE AND AGEING

Efficacy and Acceptability of Pharmacological Treatments for Depressive Disorders in Primary Care: Systematic Review and Network Meta-Analysis

(2015) K. Linde et al.   ANNALS OF FAMILY MEDICINE

The COMET initiative database: progress and activities update (2014)

(2015) Elizabeth Gargon et al.   Trials

Deviation from intention to treat analysis in randomised trials and treatment effect estimates: meta-epidemiological study

(2015) I. Abraha et al.   BMJ-British Medical Journal

Deviation from intention to treat analysis in randomised trials and treatment effect estimates: meta-epidemiological study

(2015) I. Abraha et al.   BMJ-British Medical Journal

Dissemination and publication of research findings: an updated review of related biases

(2014) F Song et al.   HEALTH TECHNOLOGY ASSESSMENT

Subjective and objective outcomes in randomized clinical trials: definitions differed in methods publications and were often absent from trial reports

(2014) Helene Moustgaard et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial

(2014) Isabelle Boutron et al.   JOURNAL OF CLINICAL ONCOLOGY

Extent of Non-Publication in Cohorts of Studies Approved by Research Ethics Committees or Included in Trial Registries

(2014) Christine Schmucker et al.   PLoS One

The trials methodological research agenda: results from a priority setting exercise

(2014) Catrin Tudur Smith et al.   Trials

Selective reporting bias of harm outcomes within studies: findings from a cohort of systematic reviews

(2014) P. Saini et al.   BMJ-British Medical Journal

Evidence for the Selective Reporting of Analyses and Discrepancies in Clinical Trials: A Systematic Review of Cohort Studies of Clinical Trials

(2014) Kerry Dwan et al.   PLOS MEDICINE

Composite Outcomes in Cardiovascular Research: A Survey of Randomized Trials

(2013) Eric Lim et al.   ANNALS OF INTERNAL MEDICINE

The comet initiative

(2013) Paula Williamson   Trials

Reporting of industry funded study outcome data: comparison of confidential and published data on the safety and effectiveness of rhBMP-2 for spinal fusion

(2013) M. A. Rodgers et al.   BMJ-British Medical Journal

Completeness of Reporting of Patient-Relevant Clinical Trial Outcomes: Comparison of Unpublished Clinical Study Reports with Publicly Available Data

(2013) Beate Wieseler et al.   PLOS MEDICINE

Developing core outcome sets for clinical trials: issues to consider

(2012) Paula R Williamson et al.   Trials

Problems of stopping trials early

(2012) G. H. Guyatt et al.   BMJ-British Medical Journal

Potential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review

(2012) E. A. Akl et al.   BMJ-British Medical Journal

Use of relative and absolute effect measures in reporting health inequalities: structured review

(2012) N. B. King et al.   BMJ-British Medical Journal

Risk factors and interventions with statistically significant tiny effects

(2011) G. C. Siontis et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Reporting and Interpretation of Randomized Controlled Trials With Statistically Nonsignificant Results for Primary Outcomes

(2010) Isabelle Boutron   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Systematic Review of Measures of Clinical Significance Employed in Randomized Controlled Trials of Drugs for Dementia

(2009) Frank J. Molnar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Outcome Reporting in Industry-Sponsored Trials of Gabapentin for Off-Label Use

(2009) S. Swaroop Vedula et al.   NEW ENGLAND JOURNAL OF MEDICINE

Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

(2008) Lesley Wood et al.   BMJ-British Medical Journal