Anticancer and antimicrobial activities of scorpion venoms and their peptides

The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells

(2016) Saranya Satitmanwiwat et al.   BIOMEDICINE & PHARMACOTHERAPY

Chlorotoxin: Structure, activity, and potential uses in cancer therapy

(2016) Paola G. Ojeda et al.   BIOPOLYMERS

Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus

(2016) Patrick L. Harrison et al.   TOXICON

Characterization of TistH, a multifunctional peptide from the scorpion Tityus stigmurus : Structure, cytotoxicity and antimicrobial activity

(2016) Richele J.A. Machado et al.   TOXICON

Investigation of in vivo potential of scorpion venom against skin tumorigenesis in mice via targeting markers associated with cancer development

(2016) Abdulrahman Al-Asmari et al.   Drug Design Development and Therapy

Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

(2016) Tengfei Xu et al.   Scientific Reports

A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro

(2016) Zhengyang Zeng et al.   Toxins

BmKn-2 Scorpion Venom Peptide for Killing Oral Cancer Cells by Apoptosis

(2015) Pirut Tong-ngam et al.   Asian Pacific Journal of Cancer Prevention

A novel cysteine-free venom peptide with strong antimicrobial activity against antibiotics-resistant pathogens from the scorpionOpistophthalmus glabrifrons

(2015) Aorigele Bao et al.   JOURNAL OF PEPTIDE SCIENCE

Investigation of the role of disulphide bond in modulating internal motions of BmK AGAP protein by molecular dynamics simulation

(2015) Yong Cui et al.   MOLECULAR SIMULATION

Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin

(2015) Edinara Targino de Melo et al.   PEPTIDES

Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity

(2015) Santos Ramírez-Carreto et al.   PEPTIDES

Scorpion venom components as potential candidates for drug development

(2015) Ernesto Ortiz et al.   TOXICON

Analgesic-antitumor peptide inhibits the migration and invasion of HepG2 cells by an upregulated VGSC β1 subunit

(2015) Guili Guo et al.   TUMOR BIOLOGY

Virocidal activity of Egyptian scorpion venoms against hepatitis C virus

(2015) Alaa MH El-Bitar et al.   Virology Journal

AaeAP1 and AaeAP2: Novel Antimicrobial Peptides from the Venom of the Scorpion, Androctonus aeneas: Structural Characterisation, Molecular Cloning of Biosynthetic Precursor-Encoding cDNAs and Engineering of Analogues with Enhanced Antimicrobial and Anticancer Activities

(2015) Qiang Du et al.   Toxins

Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells

(2014) Teerakul Arpornsuwan et al.   International Journal of Peptide Research and Therapeutics

Antimicrobial and Antibiofilm Activity of Mauriporin, a Multifunctional Scorpion Venom Peptide

(2014) Ammar Almaaytah et al.   International Journal of Peptide Research and Therapeutics

Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer

(2014) Shifen Wu et al.   PEPTIDES

Characterization of Antibacterial and Hemolytic Activity of Synthetic Pandinin 2 Variants and Their Inhibition against Mycobacterium tuberculosis

(2014) Alexis Rodríguez et al.   PLoS One

Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1

(2013) Wei Hong et al.   ANTIVIRAL RESEARCH

Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: Evaluation of their antimicrobial and anticancer activities

(2013) Xiaoxiao Guo et al.   BIOCHIMIE

Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus

(2013) Wei Hong et al.   BIOMATERIALS

Mauriporin, a Novel Cationic α-Helical Peptide with Selective Cytotoxic Activity Against Prostate Cancer Cell Lines from the Venom of the Scorpion Androctonus mauritanicus

(2013) Ammar Almaaytah et al.   International Journal of Peptide Research and Therapeutics

Bengalin initiates autophagic cell death through ERK–MAPK pathway following suppression of apoptosis in human leukemic U937 cells

(2013) Shubho Das Gupta et al.   LIFE SCIENCES

Three new antimicrobial peptides from the scorpion Pandinus imperator

(2013) Xian-Chun Zeng et al.   PEPTIDES

Potent and rapid antigonococcal activity of the venom peptide BmKn2 and its derivatives against different Maldi biotype of multidrug-resistant Neisseria gonorrhoeae

(2013) Teerakul Arpornsuwan et al.   PEPTIDES

Scorpion venom peptides with no disulfide bridges: A review

(2013) Ammar Almaaytah et al.   PEPTIDES

Purification, characterization, and bioactivity of a new analgesic-antitumor peptide from Chinese scorpion Buthus martensii Karsch

(2013) Jian-Hua Shao et al.   PEPTIDES

Mucroporin-M1 Inhibits Hepatitis B Virus Replication by Activating the Mitogen-activated Protein Kinase (MAPK) Pathway and Down-regulating HNF4αin Vitroandin Vivo

(2012) Zhenhuan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer

(2012) Yao Nie et al.   PEPTIDES

Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: Biochemical and functional characterization of natural peptides and a single site-substituted analog

(2012) Ammar Almaaytah et al.   PEPTIDES

StCT2, a new antibacterial peptide characterized from the venom of the scorpion Scorpiops tibetanus

(2012) Luyang Cao et al.   PEPTIDES

Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae

(2012) Santos Ramírez-Carreto et al.   PEPTIDES

Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7

(2012) Yaoqing Chen et al.   PLoS One

Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis

(2011) Rongqin Huang et al.   BIOMATERIALS

Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells

(2011) Youlong Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom

(2011) Ilhem Rjeibi et al.   PEPTIDES

Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses

(2011) Qiaoli Li et al.   PEPTIDES

Alpha-helical cationic antimicrobial peptides: relationships of structure and function

(2010) Yibing Huang et al.   Protein & Cell

BmKCT toxin inhibits glioma proliferation and tumor metastasis

(2009) Shaozhong Fan et al.   CANCER LETTERS

Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: Through mitochondrial pathway and inhibition of heat shock proteins

(2009) Shubho Das Gupta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibition of Tumor-Cell Invasion with Chlorotoxin-Bound Superparamagnetic Nanoparticles

(2008) Omid Veiseh et al.   Small