Article
Chemistry, Multidisciplinary
Arif Khan, Fatima Naaz, Rafia Basit, Deepak Das, Piyush Bisht, Majeed Shaikh, Bilal Ahmad Lone, Yuba Raj Pokharel, Qazi Naveed Ahmed, Shazia Parveen, Intzar Ali, Shashank Kumar Singh, Gousia Chashoo, Syed Shafi
Summary: A series of novel 1,2,3-triazole derivatives of capsaicin, including a new natural product hybrid capsaicinoid, were synthesized. Most of the synthesized compounds showed antiproliferative activity against various cancer cell lines, with lung cancer cell lines being the most sensitive. Compound 18f demonstrated the best antiproliferative activity and acted through inducing cell apoptosis and altering mitochondrial membrane potential.
Article
Biology
Inah Gu, Cindi Brownmiller, Luke Howard, Sun-Ok Lee
Summary: This study evaluated the chemical composition of volatile extracts from black raspberries, blueberries, and blackberries and investigated their antiproliferative effect and apoptotic mechanisms on lung cancer cells. The results showed that volatile extracts from these berries have antiproliferative effects on lung cancer cells partially through apoptosis.
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Han-Lin Hsu, Bo-Jyun Lin, Yu-Chen Lin, Chih-Chieh Tu, Nham-Linh Nguyen, Ching-Chiung Wang, Mei-Chuan Chen, Chun-Han Chen
Summary: This study demonstrates that Cucurbitacin E has potential as a promising drug candidate for NSCLC by inhibiting cell viability and proliferation in EGFR and KRAS mutated NSCLC cells through modulation of cell cycle progression and protein phosphorylation levels.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Engineering, Chemical
El-Sayed Khafagy, Ahmed Al Saqr, Hadil Faris Alotaibi, Amr Selim Abu Lila
Summary: Rubus chingii ethanolic leaf extract (RcL-EtOH) exhibits significant anticancer potential against non-small cell lung cancer A549 cells by inducing cell apoptosis, regulating apoptotic gene expression, and showing minimal toxicity to normal cells. RcL-EtOH may serve as a promising therapeutic option for lung cancer management.
Article
Medicine, Research & Experimental
Darja Koutova, Negar Maafi, Darina Muthna, Karel Kralovec, Jana Kroustkova, Filip Pidany, Abdul Aziz Timbilla, Eva Cermakova, Lucie Cahlikova, Martina Rezacova, Radim Havelek
Summary: The isoquinoline alkaloids found in Amaryllidaceae have potential for the development of new drugs. In this study, the cytotoxic activities of montanine and its derivatives were evaluated against multiple cancer cell lines, and it was found that montanine exhibited the most potent antiproliferative activity and induced apoptosis in MOLT-4 cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Payel Dey, Soumyajit Biswas, Rima Das, Sandipan Chatterjee, Utpal Ghosh
Summary: This study explores the synergistic anticancer activities of olaparib combined with a p38 MAPK inhibitor, SB203580, on non-small cell lung carcinoma A549 cells. The results demonstrate that while olaparib and SB203580 individually reduce cell viability in a dose-dependent manner, their combination synergistically reduces cell viability. The combination treatment enhances the anticancer potential of olaparib by increasing DNA damage-induced apoptosis and inhibiting telomerase activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Meng Wang, Zhikun Liu, Xiaochao Huang, Yuanhang Chen, Yanming Wang, Jing Kong, Yong Yang, Chunhao Yu, Jin Li, Xu Wang, Hengshan Wang
Summary: Novel dual target platinum(IV) complexes showed effective antitumor activities with lower toxicity and resistance factors than standard platinum-based chemotherapeutics, by modulating proapoptosis and prosurvival protein expression levels in cancer cells through mitochondrial dysfunction-induced mechanisms. Compound 11 has the potential to be a lead compound for future cancer therapy due to its potency and selectivity.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wan Nur Baitty Wan Mohd Tajuddin, Faridah Abas, Iekhsan Othman, Rakesh Naidu
Summary: Diarylpentanoid (DAP) analog MS13 demonstrates antiproliferative and apoptotic activities in squamous cell carcinoma and adenocarcinoma of NSCLC cells by modulating differentially expressed genes associated with PI3K-AKT, cell cycle-apoptosis, and MAPK pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qing Wang, Liqiong Zhang, Youchuan Xiao, Asghar Ghaemnezhad
Summary: Phytopharmaceuticals can enhance the effectiveness of conventional chemotherapy and reduce drug resistance in cisplatin-based chemotherapy. This study investigated the effects of diosgenin (DG) combined with cisplatin on apoptosis and its mechanisms in non-small cell lung cancer cells, and found that DG significantly increased the cytotoxic effects of cisplatin and induced apoptosis in tumor cells.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Dalila Iacopini, Jan Vanco, Sebastiano Di Pietro, Vittorio Bordoni, Stefano Zacchini, Fabio Marchetti, Zdenek Dvorak, Tomas Malina, Lorenzo Biancalana, Zdenek Travnicek, Valeria Di Bussolo
Summary: Glycoconjugation is a powerful strategy to enhance the anticancer activity of metal complexes. In this study, glycoconjugated ruthenium(II) p-cymene complexes were synthesized by modifying commercial arylphosphanes with carbohydrate-derived fragments. These complexes exhibited significant cytotoxicity against various cancer cell lines and showed potential as novel anticancer agents.
BIOORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Siraprapa Saetan, Wanida Sukketsiri, Pennapa Chonpathompikunlert, Wanwimol Klaypradit, Mantira Hawangjoo, Nujamee Ngasakul, Supita Tanasawet
Summary: This study investigated the anticancer effects of tuna blood on non-small cell lung cancer (NSCLC) A549 cells. The results showed that tuna blood cell freeze-dried (TRBF) had a stronger inhibitory effect on cell proliferation compared to tuna whole blood freeze-dried (TWBF). Mechanistically, TRBF induced apoptosis through the regulation of p38 MAPK and Akt signaling pathways.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Felix Glaser, Petra Hundehege, Etmar Bulk, Luca Matteo Todesca, Sandra Schimmelpfennig, Elke Nass, Thomas Budde, Sven G. Meuth, Albrecht Schwab
Summary: This study investigates whether blocking K(Ca)3.1 channels increases the sensitivity of NSCLC cells towards the EGFR TKI erlotinib and overcomes drug resistance. The results show that K(Ca)3.1 channel blockade can enhance the sensitivity of NSCLC cells to erlotinib, and partial erlotinib resistance can be overcome by this blockade.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ling Jin, Minkyoung Cho, Bo-Sung Kim, Jung Ho Han, Sungmi Park, In-Kyu Lee, Dongryeol Ryu, Jae Ho Kim, Sung-Jin Bae, Ki-Tae Ha
Summary: The study revealed that A549 cells with PDHA1(WT) and PDHA1(3SD) can be used as a cell-based system to distinguish PDK inhibitors. Some inhibitors induced apoptosis dependent on PDH activity, while others enhanced PDHA1 activity with low toxicity to cancer cells. The complexity of PDHA1 regulation was also highlighted, requiring further investigation.
Article
Plant Sciences
Lingling Zhang, Bing Liang, Huan Xu, Yanju Gong, Wangming Hu, Zhong Jin, Xiao Wu, Xiongbin Chen, Min Li, Liangqin Shi, Yaping Shi, Yong Wang, Lan Yang
Summary: The study demonstrates that cinobufagin suppresses the malignant behaviors of NSCLC cells in vivo and in vitro by inhibiting the expression of histone methyltransferase G9a and activating the tumor suppressor gene FOXO1. These findings provide important insights into the molecular mechanism underlying the anticancer activity of cinobufagin and suggest that it could be a potential candidate for targeted cancer therapy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Amanda Alvim Negreti, Guilherme Alvaro Ferreira-Silva, Carolina Girotto Pressete, Rafael Fonseca, Caio C. Candido, Angelica E. Graminha, Antonio Carlos Doriguetto, Ester Siqueira Caixeta, Joao Adolfo Costa Hanemann, Angel Mauricio Castro-Gamero, Marilia I. F. Barbosa, Marta Miyazawa, Marisa Ionta
Summary: In this study, three ruthenium(ii) complexes containing cinnamic acid derivatives as ligands were synthesized and evaluated for their cytotoxic effects on melanoma cell lines. The results showed that one particular complex exhibited the most promising inhibitory activity, affecting cell cycle progression, inducing apoptosis, and inhibiting cell migration.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Food Science & Technology
Nathalia da Silva Campos, Igor Lima de Paula, Italo Tuler Perrone, Luiz Fernando Cappa de Oliveira, Antonio Carlos Doriguetto, Alan Wolfschoon, Rodrigo Stephani
Summary: This study characterized the white dots in doce de leite using various analytical techniques. Results showed that the white dots were composed mainly of calcium citrate hexahydrate (CCH), amino acids, and a small amount of phosphates. The study also identified the formation mechanism of the white dots, suggesting the role of alpha(s1)-casein in heterogeneous nucleation and crystal growth.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ana Luisa A. Lage, Luisa A. Ribeiro, Antonio C. Doriguetto, Carlos B. Pinheiro, Wallace C. Nunes, Emerson F. Pedroso, Cynthia L. M. Pereira
Summary: This study presents the synthesis, crystal structure, and magnetic properties of a neutral hexacopper(II) complex, which exhibits a unique crystal structure with trinuclear units connected by oxamate bridges and shows both antiferromagnetic and ferromagnetic interactions through magnetic measurements.
Review
Biochemistry & Molecular Biology
Jaqueline Carvalho de Oliveira
Summary: Ultraconserved regions (UCRs) are highly conserved genomic elements in humans, mice, and rats. Despite their primarily non-coding nature, some transcribed UCRs (T-UCRs) have been implicated in pathological conditions, particularly cancer. This review focuses on T-UCRs involved in cancer cell signaling and their potential as prognostic markers. Out of 481 T-UCRs, 297 show differential expression in cancer samples, with 23 implicated in tumorigenesis and 12 showing potential as prognostic markers. T-UCRs represent important molecules in cancer networks and have potential clinical implications, but further research is needed.
GENETICS AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caio Cesar Candido, Henrique Vieira Reis Silva, Bruno Zavan, Marisa Ionta, Marilia Imaculada Frazao Barbosa, Antonio Carlos Doriguetto
Summary: In this study, novel ruthenium(II) complexes with metronidazole as a ligand were synthesized and characterized. The results showed that complexes (1) and (3) exhibited inhibitory effects on the proliferation of MCF-7 cells and induced apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Henrique Vieira Reis Silva, Guilherme Alvaro Ferreira da Silva, Bruno Zavan, Rafael Pereira Machado, Joao Honorato de Araujo-Neto, Javier Alcides Ellena, Marisa Ionta, Marilia Imaculada Fraza, Antonio Carlos Doriguetto
Summary: A series of new ruthenium complexes were synthesized and characterized. These complexes interacted with DNA and human serum albumin and exhibited cytotoxicity against various cancer cells. One of the complexes showed higher toxicity against melanoma cells, inhibited clonogenic capacity, induced cell cycle arrest, and triggered apoptosis through the production of reactive oxygen species.
Article
Biochemistry & Molecular Biology
Ana Carolina Rodrigues, Erika Pereira Zambalde, Daniel de Lima Bellan, Edvaldo da Silva Trindade, Enilze Maria de Souza Fonseca Ribeiro, George Calin, Daniela Fiori Gradia, Jaqueline Carvalho de Oliveira
Summary: This study aimed to investigate the role of long non-coding RNA lnc-uc.147 in different types of cancer and suggest its functional and regulation aspects. The results showed that deregulated expression of lnc-uc.147 was associated with histologic grade in hepatocellular carcinoma and tumor stage in clear cell renal and gastric adenocarcinoma. Silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, a relationship between the transcription factor TEAD4 and lnc-uc.147 was suggested in liver and breast cancer cells.
Article
Chemistry, Medicinal
Carolina Girotto Pressete, Flavia Pereira Dias Viegas, Thamara Gaspar Campos, Ester Siqueira Caixeta, Joao Adolfo Costa Hanemann, Guilherme Alvaro Ferreira-Silva, Bruno Zavan, Alexandre Ferro Aissa, Marta Miyazawa, Claudio Viegas-Jr, Marisa Ionta
Summary: Melanoma, the most aggressive form of skin cancer, remains highly metastatic and deadly despite advances in immunotherapy and targeted therapies. In this study, we designed hybrid compounds combining pharmacophores from piperine and chlorogenic acid to explore potential antitumoral properties. Among the compounds tested, PQM-277 (3a) showed the highest cytotoxicity on melanoma cells, inhibiting mitosis progression and altering gene expression related to G2/M transition and mitosis onset. Furthermore, compound 3a interacted with the CUL1-RBX1 complex and induced apoptosis by increasing the BAX/BCL2 ratio. These findings suggest that compound 3a has promising potential as an antitumor candidate for melanoma treatment, especially in refractory cases.
Article
Chemistry, Physical
Carlos Henrique de Moura Oliveira, Joao Honorato de Araujo Neto, Javier Alcides Elenna, Josidel Conceicao Oliver, Amanda Latercia Tranches Dias, Ivo Santana Caldas, Antonio Carlos Doriguetto
Summary: This study introduces two poly-iodide compounds, SMZ[I5].H2O and SDZ2[I4], which overcome the limitation of high oral dosage required for SMZ and SDZ drugs. The characteristics of SMZ[I5].H2O and SDZ2[I4] were systematically characterized using various techniques. In vitro experiments demonstrated the enhanced antimicrobial activity of SMZ[I5].H2O compared to unmodified SMZ.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Genetics & Heredity
Carolina Mathias, Anelis Maria Marin, Ana Flavia Kohler, Heloisa Bruna Soligo Sanchuki, Natalie Sukow, Marcia Holsbach Beltrame, Suelen Cristina Soares Baal, Ana Paula Martins Sebastiao, Enilze Maria de Souza Fonseca Ribeiro, Daniela Fiori Gradia, Mateus Nobrega Aoki, Jaqueline Carvalho de Oliveira
Summary: Long noncoding RNAs (lncRNAs) are a type of RNA molecule that do not code for proteins and have a regulatory role. This study identified lncRNA-SNPs with a potential biological role in the development of breast cancer (BC) in the Brazilian population. Certain SNPs were found to be associated with BC development and patient characteristics.
Article
Chemistry, Physical
Cristiane B. Goncalves, Rafael T. da Silva, Gustavo Dalenogare, Isabelle M. D. Gonzaga, Lucia H. Mascaro, Mateus M. Ferrer, Marcelo Assis, Elson Longo, Hugo B. de Carvalho, Antonio C. Doriguetto
Summary: This study presents a comprehensive analysis of morphology, microstructure, and optical properties of electrodeposited Cu2O thin films on SnO2:F substrates. The films exhibited stability, purity, and crystallinity, with various morphologies and growth orientations. These findings make a significant contribution to the exploration of multifunctional semiconductor materials for various advanced technologies.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Marilia I. F. Barbosa, Rodrigo S. Correa, Adriana P. M. Guedes, Alex M. Graca, Francyelli M. Andrade, Celisnolia M. Leite, Elisangela P. Silveira-Lacerda, Javier Ellena, Henrique V. Reis, Antonio C. Doriguetto, Alzir A. Batista
Summary: Herein, we report on the synthesis and characterization of ruthenium compounds with different amino acids as ligands. The complexes were characterized using various techniques and the structures of two compounds were determined using X-ray diffraction. In vitro evaluation showed that these compounds exhibited cytotoxic activities against triple-negative breast cancer cells and inhibited their migration. Therefore, these compounds may be promising drug candidates for the treatment of triple-negative breast cancer.
Article
Biochemistry & Molecular Biology
Cintia A. Simosono, Rafaela M. R. da Silva, Nathalia R. De Campos, Marye Agnes R. Silva, Antonio C. Doriguetto, Leona S. Flores, Charlane C. Correa, Tatiana R. G. Simoes, Ana Karoline S. M. Valdo, Felipe T. Martins, Flavio Garcia, Guilherme P. Guedes, Breno R. L. Galvao, Juliana Cancino-Bernardi, Ricardo D. dos Reis, Humberto O. Stumpf, Danielle D. Justino, Paulo F. R. Ortega, Walace D. do Pim, Miguel Julve, Maria Vanda Marinho
Summary: In this article, the synthesis, crystal structure, and electronic properties of two compounds containing {Ni-2(II)} helical units were described. Both compounds exhibit reversible redox reactions mediated by OH- ions, but with different formal potentials reflecting changes in molecular orbital energy levels. One compound forms a 2D coordination network through connection with K+ counter cations, while the other compound forms a 2D array through supramolecular interactions with a [Ni(H2O)(6)](2+) complex cation.
Article
Chemistry, Multidisciplinary
Carla Miguel de Oliveira, Renato de Oliveira Horvath, Rafael Fonseca, Kris Simone Tranches Dias, Marisa Ionta, Claudio Viegas Jr
Summary: This study evaluated a series of N-benzyl-piperidinyl acylhydrazone hybrid derivatives for their cytotoxic activity on non-small cell lung cancer (A549) and hepatocellular carcinoma (HepG2) cells. PQM-75 (6i) exhibited the best antiproliferative activity against HepG2 cells, while PQM-88 (6k) showed the strongest activity against A549 cells. Furthermore, compound 6i demonstrated the ability to inhibit the clonogenic capacity of HepG2 cells and induce G2/M phase arrest.
REVISTA VIRTUAL DE QUIMICA
(2023)
Article
Engineering, Biomedical
Mayara Santos de Castro, Marta Miyazawa, Ester Siqueira Caixeta Nogueira, Jorge Kleber Chavasco, Gustavo Andrade Brancaglion, Claudio Daniel Cerdeira, Denismar Alves Nogueira, Marisa Ionta, Joao Adolfo Costa Hanemann, Maisa Ribeiro Pereira Lima Brigagao, Felipe Fornias Sperandio
Summary: This study evaluates the effects of PBM on human monocytes, revealing that PBM significantly increases intracellular and extracellular ROS production, enhances fungicidal capacity, and induces the expression of TNF-alpha and the production of NO in monocytes without impairing cell viability.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)