Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway

Oxyresveratrol abrogates oxidative stress by activating ERK–Nrf2 pathway in the liver

(2016) Hee Yoon Choi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

(2016) Andrew M. Kidger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation

(2015) Zhiyong Zheng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

(2015) Li-Li Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Chlorogenic acid prevents acetaminophen-induced liver injury: The involvement of CYP450 metabolic enzymes and some antioxidant signals

(2015) Chun Pang et al.   Journal of Zhejiang University-SCIENCE B

Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions

(2015) Ningjian Liang et al.   Nutrients

Tryptanthrin Protects Hepatocytes against Oxidative Stress via Activation of the Extracellular Signal-Regulated Kinase/NF-E2-Related Factor 2 Pathway

(2014) Soo Young Moon et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function

(2014) Xin Jiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States

(2014) Marissa Blieden et al.   Expert Review of Clinical Pharmacology

Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review

(2013) Shengxi Meng et al.   Evidence-based Complementary and Alternative Medicine

Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2

(2013) Carlos Sanz-Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism

(2013) Lili Ji et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Perfluorooctanoic acid induces apoptosis through the p53-dependent mitochondrial pathway in human hepatic cells: A proteomic study

(2013) Qingyu Huang et al.   TOXICOLOGY LETTERS

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells

(2012) Wen-Xu Hong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The difference of glutathione antioxidant system in newly weaned and young mice liver and its involvement in isoline-induced hepatotoxicity

(2011) Qing-Ning Liang et al.   ARCHIVES OF TOXICOLOGY

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters

(2009) Guoxiang Shen et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Heat Shock Protein gp96 Interacts with Protein Phosphatase 5 and Controls Toll-like Receptor 2 (TLR2)-mediated Activation of Extracellular Signal-regulated Kinase (ERK) 1/2 in Post-hypoxic Kidney Cells

(2009) Sanae Ben Mkaddem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective mechanisms ofN-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity

(2009) Lili Ji et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A systems biology perspective on Nrf2-mediated antioxidant response

(2009) Qiang Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acute Liver Failure in a Metropolitan Area in Germany: a Retrospective Study (2002 – 2008)

(2009) A. Canbay et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE