Article
Immunology
Xin Huang, Yiran Liu, Hong Shen, Tingting Fu, Yan Guo, Sainan Qiu
Summary: This study aimed to evaluate the effect of chlorogenic acid (CA) on inflammation in gingival tissues of periodontitis patients and explore its mechanism. The results showed that CA inhibited the inflammatory response in LPS-induced human gingival fibroblasts (HGFs) through the CysLT1R/Nrf2/NLRP3 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Yang Yao, Rong Li, Dan Liu, Lihui Long, Na He
Summary: This study found that rosmarinic acid (RA) has a protective role against acetaminophen (APAP)-induced hepatotoxicity (AILI) by inhibiting ROS production and the NEK7-NLRP3 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Yuan An, Qiang Luo, Donghai Han, Lianyue Guan
Summary: This study found that abietic acid has a protective effect on acetaminophen-induced liver injury by reducing inflammation and ferroptosis. It can inhibit NF-KB activation and increase the expression of Nrf2 and HO-1. The results in Nrf2-/- mice and in vitro experiments confirmed the therapeutic effects of abietic acid.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yihui Zheng, Luyao Li, Binwen Chen, Yu Fang, Wei Lin, Tianlei Zhang, Xiaoli Feng, Xiaoyue Tao, Yiqing Wu, Xiaoqin Fu, Zhenlang Lin
Summary: Chlorogenic acid (CGA) has potential neuroprotective effects on neonatal hypoxic-ischemic brain injury (HIE), reducing infarct volume, improving tissue structure, and enhancing learning and cognitive abilities. CGA activates Sirt1 to regulate the Nrf2-NF-kappa B signaling pathway, reducing inflammation and oxidative stress and inhibiting neuronal apoptosis. Additionally, CGA suppresses glial proliferation.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Geriatrics & Gerontology
Ferbian Milas Siswanto, Rika Sakuma, Ami Oguro, Susumu Imaoka
Summary: Chlorogenic acid (CGA), the most abundant polyphenol in coffee, exhibits antioxidant activity by activating the Nrf2 pathway. This study revealed that CGA inhibits FOXO3 nuclear accumulation and decreases the expression of DDB1, leading to increased Nrf2 activity. The study also found that CGA extends the lifespan of C. elegans through this pathway.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Betul Danisman, Mustafa Ozkaraca, Behzad Mokhtare, Mecit Kantarci, Marios Spanakis, Dragana Nikitovic, Georgios Lazopoulos, Konstantinos Tsarouhas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This research evaluated the cardioprotective properties of chlorogenic acid (CGA) in doxorubicin (DOX)-induced cardiotoxicity and identified one of the possible mechanisms for its protective effects. The study found that CGA ameliorated oxidative stress and cardiomyocyte apoptosis by upregulating the Nrf2/HO-1-dependent pathway and downregulating dityrosine (DT) expression. These findings suggest that CGA may be cardioprotective, particularly in patients receiving DOX-based chemotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Wan Wang, Hang Shang, Jinzhe Li, Yue Ma, Cong Xu, Jiage Ma, Juncai Hou, Zhanmei Jiang
Summary: Polyphenols have potential protective effects on ethanol-induced liver injury by inhibiting cytotoxicity and oxidative stress, restoring intestinal permeability and gene expression, and promoting nuclear translocation of Nrf2. The dietary polyphenols DMY and API show the best ability to inhibit CYP2E1 and Keap1. Molecular docking experiments reveal that DMY and API can bind tightly to specific amino acid residues, suggesting their inhibitory effects on CYP2E1 and Keap1.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Shaohua Liang, Quan Zhao, Xianzhi Wei, Cong Sun
Summary: In this study, chlorogenic oleate (CGO) was efficiently synthesized through acylation of chlorogenic acid (CGA) and oleoyl chloride. By optimizing the reaction conditions, the researchers successfully obtained a high purity product. The best synthesis conditions, including substrate molar ratio, adding method, reaction time, and temperature, were determined through experiments.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Feng Gao, Kaiqiang Fu, Huatao Li, Yanni Feng, Wenru Tian, Rongfeng Cao
Summary: The study successfully established a mouse model of clinical endometritis using five LC uterine perfusions, and confirmed the anti-inflammatory and antioxidant effects of CGA.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Shan Wang, Yue Li, Xiangyong Meng, Shangwei Chen, Dejian Huang, Yongmei Xia, Song Zhu
Summary: In this study, chlorogenic acid was acylated with different carbon chain lengths to produce derivatives with varying lipophilicities, which were found to have enhanced antioxidant activities in cellular antioxidant activity tests. The results indicated that the lipophilicities of the derivatives positively correlated with their digestive stabilities and cellular antioxidant activities. Among the derivatives, C12-CA exhibited the best antioxidant activity with a significantly lower effective dose compared to CA.
Review
Biochemistry & Molecular Biology
Rekha Thiruvengadam, Baskar Venkidasamy, Ramkumar Samynathan, Rajakumar Govindasamy, Muthu Thiruvengadam, Jin Hee Kim
Summary: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular antioxidant defense. It can be activated by oxidative stress and various factors and modifications. Keap1/Nrf2/ARE signaling is a target for treating diseases. Nanomaterials have unique properties and can be used in various biological applications. This review discusses the combined therapy of nanoparticles and Nrf2 and their significance in diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Wujing Dai, Qin. M. M. Chen
Summary: The Nrf2 gene encodes a transcription factor that regulates antioxidant and detoxification gene expression. Fresh DMEM and L-Cystine can induce Nrf2 protein in various cell types, leading to the activation of Nrf2 downstream genes and cytoprotection against oxidative stress and tissue injury.
Article
Agriculture, Dairy & Animal Science
Huawei Liu, Xuemin Li, Shuyan Shi, Yingjun Zhou, Kai Zhang, Yang Wang, Jinshan Zhao
Summary: Chlorogenic acid (CGA) has positive effects on growth performance and intestinal health in oxidatively stressed broilers, acting through the activation of the autophagy-mediated Nrf2 pathway.
Article
Immunology
Sameh S. Zaghlool, Nashwa Abdelaal, Ehab A. M. El-Shoura, Nesreen I. Mahmoud, Yasmin M. Ahmed
Summary: This study found that sulforaphane (SFN) has a protective effect against folic acid-induced acute renal injury through its antioxidant, anti-inflammatory, and anti-apoptotic activities, thus providing a potential therapeutic strategy for preventing such injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Young-Joo Suh, Hyo-Jeong Yun, Yu-Bin Kim, Eun-Jung Kang, Jung Hyeon Choi, Young-Keun Choi, In-Bok Lee, Dong-Hee Choi, Yun Jeong Seo, Jung-Ran Noh, Jong-Soo Lee, Yong-Hoon Kim, Chul-Ho Lee
Summary: This study reveals the role of DAX-1 in APAP-induced liver injury. Hepatocyte-specific DAX-1 deficiency can protect against APAP-induced liver injury by regulating the Nrf2-mediated antioxidant defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Sukfan P. Kwong, Zhenlin Huang, Lili Ji, Changhong Wang
Summary: The study investigated the mechanism of UA-induced liver toxicity, revealing that it induces oncotic L02 cell death by increasing protein porimin and forming irreversible membrane pores. This area may be a potential research focus in bioactivity and toxicology.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Lei Li, Sheng-he Li, Jin-peng Jiang, Chang Liu, Li-li Ji
Summary: This study investigated the mechanisms of andrographolide against NASH using network pharmacology, showing that it inhibits NASH development through regulation of de novo fatty acids synthesis, anti-inflammation and anti-oxidation pathways.
CHINESE HERBAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Jingnan Zhang, Fan Yang, Xiyu Mei, Rui Yang, Bin Lu, Zhengtao Wang, Lili Ji
Summary: Toosendanin (TSN) and isotoosendanin (ITSN) are natural triterpenoids that inhibit the growth of triple-negative breast cancer (TNBC) by inducing necrosis, apoptosis, and autophagy in tumor cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Plant Sciences
Li Lin, Xinnan Gu, Liangni Chen, Tianyu Zhang, Changhong Wang, Zhengtao Wang, Qingling You, Lili Ji
Summary: FSGT capsule alleviates RA in CIA mice by reducing inflammation, abrogating angiogenesis, and relieving pain. Some compounds in FSGT, including BHA, GA, PSE, ISL, QUER, and KAE, reduced both inflammation and angiogenesis in vitro, indicating their potential contribution to the alleviation provided by FSGT capsule on RA.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Shihao Yan, Shaobo Zhang, Ao Du, Hui Miao, Bin Lu, Zhenlin Huang, Lili Ji
Summary: The study showed that Yinhuang granule (YHG) could alleviate MCD-induced metabolic-associated fatty liver disease (MAFLD) in mice by reducing hepatic lipids accumulation, alleviating liver oxidative and inflammatory injury, and attenuating hepatic fibrosis.
Article
Plant Sciences
Shaobo Zhang, Zeqi Wu, Liang Shi, Shihao Yan, Zhenlin Huang, Bin Lu, Zhengtao Wang, Lili Ji
Summary: This study observed the improvement of 2,3,5,4'-tetrahydroxy-stilbene-2-O-beta-D-glucoside (TSG) on methionine and choline deficient (MCD) diet-induced non-alcoholic fatty liver disease (NAFLD) in mice and elucidated its mechanism. The results showed that TSG could attenuate liver injury, inhibit inflammatory responses and fibrosis, and significantly improve liver steatosis. In addition, TSG could prevent lipid accumulation and improve mitochondrial dysfunction through regulating the expression of SIRT5.
Article
Chemistry, Medicinal
Hao Ouyang, Ao Du, Lingyu Zhou, Tianyu Zhang, Bin Lu, Zhengtao Wang, Lili Ji
Summary: Chlorogenic acid (CGA) offers protection against diabetic retinopathy (DR) by attenuating blood-retinal barrier (BRB) dysfunction through inhibiting inflammation and inducing Nrf2 activation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xi-yu Mei, Jing-nan Zhang, Wang-ya Jia, Bin Lu, Meng-na Wang, Tian-yu Zhang, Li-li Ji
Summary: In this study, researchers found that Scutellarin (SC), a natural flavonoid, can reduce the metastasis of triple-negative breast cancer (TNBC) by alleviating tumor-associated vascular endothelial barrier injury. SC regulates the TNF alpha-TNFR2-ERK1/2-EZH2 signaling pathway and restores the reduced expression of junctional proteins, thereby suppressing TNBC metastasis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Hui Miao, Hao Ouyang, Qian Guo, Mengjuan Wei, Bin Lu, Guoyin Kai, Lili Ji
Summary: Chlorogenic acid (CGA) alleviated liver fibrosis in mice with methionine and choline deficient (MCD) diet-induced nonalcoholic steatohepatitis by inhibiting hepatic stellate cells activation, promoting mitochondrial biogenesis, and reducing high mobility group box 1-initiated extracellular matrix production in hepatic vascular endothelial cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mengjuan Wei, Yi Zhang, Hong Zhang, Zhenlin Huang, Hui Miao, Tianyu Zhang, Bin Lu, Lili Ji
Summary: This study observed that HMGB1-induced EndoMT and ECM play important roles in the development of liver fibrosis, with Egr1 playing a key role in this process. It was found that the natural compound silymarin attenuated liver fibrosis in mice induced by CCl4 by increasing Egr1 nuclear accumulation, decreasing serum HMGB1 content, and inhibiting hepatic EndoMT.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Plant Sciences
Wangya Jia, Keke Wang, Shaobo Zhang, Wenxu Lu, Ao Du, Jian Li, Lili Ji, Hong Xu
Summary: This study observed the in vivo alleviation of Mailuoning Oral Liquid (MLN) on non-alcoholic steatohepatitis (NASH) and explored the underlying mechanism. The results demonstrated that MLN improved NASH in mice and the PGC-1α-PPARα signaling pathway was involved in this process. Furthermore, Achyranthis bidentatae radix and Lonicerae japonicae flos contained in MLN contributed greatly to the MLN-provided improvement on NASH.
Article
Plant Sciences
Mengjuan Wei, Zhimiao Qiu, Han Li, Bin Lu, Changhong Wang, Lili Ji
Summary: SKN was found to alleviate ADR-induced nephropathy by suppressing renal inflammation and oxidative stress injury through inhibiting NF-kappa B activation and activating Nrf2 signaling pathway. Furthermore, Astragali Radix (Huangqi) played a crucial contribution to this ameliorative effect.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinnan Gu, Mengjuan Wei, Feifei Hu, Hao Ouyang, Zhenlin Huang, Bin Lu, Lili Ji
Summary: In this study, it was found that chlorogenic acid (CGA) effectively improved non-alcoholic steatohepatitis (NASH) by inhibiting hepatic inflammation. CGA alleviated liver oxidative injury by activating nuclear factor erythroid 2-related factor 2 (Nrf2) and reduced liver steatosis by up-regulating peroxisome proliferator-activated receptor-alpha (PPAR alpha). Furthermore, CGA blocked the LPS-TLR4-MyD88 signaling pathway and attenuated hepatic inflammation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Plant Sciences
Haoyu Xue, Mengjuan Wei, Lili Ji
Summary: This review analyzes the hepatoprotective effect of chlorogenic acids (CGAs) and their mechanisms. CGAs have been found to improve various liver diseases, including drug-induced liver injury, alcoholic liver disease, metabolic-associated fatty liver disease, cholestatic liver disease, liver fibrosis, and liver cancer. They exhibit remarkable antioxidant and anti-inflammatory effects by activating Nrf2 and inhibiting TLR4/NF-kappa B signaling pathways, and also involve key molecules such as AMPK and ERK1/2, as well as physiological processes like intestinal barrier and gut microbiota.
Article
Pharmacology & Pharmacy
Hui Qian, Qingyun Bai, Xiao Yang, Jephte Y. Akakpo, Lili Ji, Li Yang, Thomas Rulicke, Kurt Zatloukal, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding
Summary: The study revealed the crucial role of p62 in APAP-induced liver injury (AILI), showing that it inhibits the late injury phase by enhancing autophagic selective removal of APAP adducts and mitochondria while impairing the recovery phase likely by enhancing hepatic blood coagulation.
ACTA PHARMACEUTICA SINICA B
(2021)
