Review
Biochemistry & Molecular Biology
Parviz Vahedi, Rana Moghaddamshahabi, Thomas J. Webster, Ayse Ceren Calikoglu Koyuncu, Elham Ahmadian, Wasim S. Khan, Ali Jimale Mohamed, Aziz Eftekhari
Summary: Cartilage damage is often difficult to repair, and current treatment strategies are inadequate. Autologous mesenchymal stem cells are considered a promising therapeutic approach for cartilage regeneration, as they possess robust cartilaginous production capacity and are easy to isolate and expand without causing morbidity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Ji-Yun Ko, Jeong-Won Park, Juyoung Kim, Gun-Il Im
Summary: The study demonstrated that ASC spheroids have better in vitro and in vivo survival and chondrogenic potential, exerting greater regenerative effects for articular cartilage, and arresting the progression of surgically induced OA better than ASCs in single-cell suspension through a paracrine mode of action.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Cell Biology
Isabele Camargo Brindo da Cruz, Ana Paula Pereira Velosa, Solange Carrasco, Antonio dos Santos Filho, Jurandir Tomaz de Miranda, Eduardo Pompeu, Tiago Lazzaretti Fernandes, Daniela Franco Bueno, Camila Fanelli, Claudia Goldenstein-Schainberg, Alexandre Todorovic Fabro, Ricardo Fuller, Pedro Leme Silva, Vera Luiza Capelozzi, Walcy Rosolia Teodoro
Summary: The study found that ADSC stimulated by Col V can significantly increase Col II in the degenerative area of OA rabbits, regulating the expression of cartilage-related genes, making it a promising target for OA treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Liang Lu, Xifu Shang, Bin Liu, Weijian Chen, Yu Zhang, Shuyun Liu, Xiang Sui, Aiyuan Wang, Quanyi Guo
Summary: The study demonstrated that the cartilage complex constructed by ADSCs and ACECM through tissue engineering successfully repaired cartilage defects, indicating the potential of ADSCs for chondrogenic differentiation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Retraction
Medicine, Research & Experimental
Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka, Thomas Ichim
Summary: The article has been retracted. Please refer to the Retraction Notice for more details: https://doi.org/10.1186/s12967-021-02852-z
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Manon Jammes, Romain Contentin, Fabrice Audigie, Frederic Casse, Philippe Galera
Summary: This study tested the effects of different storage conditions on the secretome of mesenchymal stromal cells (MSCs) and investigated the enhancement of MSC secretome properties through cytokine priming. The results showed that secretome stored at -80°C, -20°C, and 4°C improved collagen protein accumulation, cell proliferation, and inflammation reduction in chondrocytes. Cytokine priming had different effects on the expression of immunomodulatory molecules and influenced the behavior of equine articular chondrocytes (eACs). These findings demonstrate the potential of MSC-conditioned media for improving the management of equine osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ibrahim Vargel, Ali Tuncel, Nilsu Baysal, Irem Hartuc-Cevik, Feza Korkusuz
Summary: SVF has the potential to modulate inflammation and initiate regeneration in joint tissues, making it a potential approach for treating knee osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Anna Maria Krzesniak, Kuba Radzimowski, Artur Stolarczyk
Summary: The study aims to compare the clinical effects of treating knee osteoarthritis using adipose tissue MSC obtained by enzymatic or mechanical methods. The preparations will be administered to patients' knee joints under ultrasound control in the operating room, and the treatment outcomes will be assessed over a year.
Review
Rheumatology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: The incidence of rheumatic diseases is expected to increase due to population aging and increased physical activities among younger individuals, requiring curative strategies in addition to pain management. Mesenchymal stromal cells (MSCs) have regenerative potential due to the secretion of paracrine factors, many of which are encapsulated in extracellular vesicles (EVs) that mimic the functions of parental cells. MSC-derived EVs have anti-inflammatory, anti-apoptotic, and pro-regenerative properties, making them a promising cell-free therapy for rheumatic diseases.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Cell & Tissue Engineering
Xiao-Na Xiang, Si-Yi Zhu, Hong-Chen He, Xi Yu, Yang Xu, Cheng-Qi He
Summary: Osteoarthritis is a common degenerative disease that causes high socioeconomic costs and disability rates. The knee joint is most commonly affected, characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and inflammation. MSC-based therapy has been explored as a new regenerative treatment for knee osteoarthritis. However, the detailed functions and mechanisms of MSC-based therapy, especially for cartilage regeneration, have not been explained.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Orthopedics
Yunong Ao, Jiangjie Duan, Na Xiong, Nannan Qian, Rui Zhang, Liu Yang, Shicang Yu, Fuyou Wang
Summary: Repeated intra-articular injection of umbilical cord-derived mesenchymal stem cells (UC-MSCs) is safe and does not induce serious adverse events in the treatment of osteoarthritis (OA). This treatment may temporarily improve symptoms in patients with knee OA and may be a potential therapeutic option.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Orthopedics
Kang-Il Kim, Myung-Seo Kim, Jun-Ho Kim
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy and safety of intra-articular injections of autologous adipose-derived stem cells (ASCs) and adipose-derived stromal vascular fractions (ADSVFs) in patients with knee osteoarthritis (OA). The results showed that this treatment approach showed significant clinical efficacy and safety in terms of pain relief and functional improvement at short-term follow-up. However, the evidence for cartilage regeneration remains limited.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Pengxu Wei, Ruixue Bao
Summary: Knee osteoarthritis is a common problem, especially in older individuals, and can eventually lead to disability. Injecting mesenchymal stem cells (MSCs) into the knee joint has been shown to induce cartilage regeneration in several studies. Additionally, understanding the anatomical, biomechanical, and biochemical changes associated with knee osteoarthritis can help develop appropriate interventions to delay disease progression and improve cartilage repair induced by MSC injection. Post-injection rehabilitation programs and related mechanisms are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Brian E. Walczak, Hongli Jiao, Ming-Song Lee, Wan-Ju Li
Summary: Our study demonstrates that epigenetic reprogramming enhances the phenotypic characteristics and functions of MSCs harvested from OA patients. Additionally, reprogrammed MSCs show an improved potential for articular cartilage repair. The reprogramming strategy provides a potential solution to the challenge of variation in MSC quality.
Article
Health Care Sciences & Services
Yang Yu, Qunshan Lu, Songlin Li, Mingxing Liu, Houyi Sun, Lei Li, Kaifei Han, Peilai Liu
Summary: This study examines the efficacy and safety of autologous micro-fragmented adipose tissue (MF-AT) in improving joint function and cartilage repair in knee osteoarthritis patients. The results show improvements in WOMAC, VAS, KSS, and HSS scores at 3, 6, 9, 12, and 18 months after injection compared to before injection. There were no adverse events reported. However, the improved knee function was not sustained, with the best results occurring at 9-12 months post-injection.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Engineering, Biomedical
Gun-Il Im
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Orthopedics
Audrey McAlinden, Gun-Il Im
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Oncology
Gun-Il Im
Article
Cell & Tissue Engineering
Ji-Yun Ko, Jimin Lee, Jungsun Lee, Yang Hwan Ryu, Gun-Il Im
TISSUE ENGINEERING PART A
(2019)
Review
Cell & Tissue Engineering
Gun-Il Im
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Engineering, Biomedical
Se-Young Jeong, Mi-Lan Kang, Jeong-Won Park, Gun-Il Im
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Editorial Material
Cell & Tissue Engineering
Gun-Il Im, Chong-Su Cho
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Orthopedics
Brian Johnstone, Martin J. Stoddart, Gun-Il Im
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Medicine, Research & Experimental
Jong Min Lee, Ji-Yun Ko, Hye Young Kim, Jeong-Won Park, Farshid Guilak, Gun-Il Im
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Engineering, Biomedical
Seuk Young Song, Jihye Hong, Seukhyeong Go, Songhyun Lim, Hee Su Sohn, Mikyung Kang, Gun-Jae Jung, Jeong-Kee Yoon, Mi Lan Kang, Gun-il Im, Byung-Soo Kim
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Multidisciplinary Sciences
Mi-Lan Kang, Hye-Seon Kim, Jin You, Young Sik Choi, Byeong-Ju Kwon, Chan Hee Park, Wooyeol Baek, Min Sup Kim, Yong Jae Lee, Gun-Il Im, Jeong-Kee Yoon, Jung Bok Lee, Hak-Joon Sung
Article
Orthopedics
Jong Min Lee, Ji-Yun Ko, Jeong-Won Park, Woon Kyu Lee, Sun U. Song, Gun-Il Im
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Engineering, Biomedical
Ji-Yun Ko, Jeong-Won Park, Juyoung Kim, Gun-Il Im
Summary: The study demonstrated that ASC spheroids have better in vitro and in vivo survival and chondrogenic potential, exerting greater regenerative effects for articular cartilage, and arresting the progression of surgically induced OA better than ASCs in single-cell suspension through a paracrine mode of action.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Cell & Tissue Engineering
Gun-Il Im, Tae-Kyung Kim
INTERNATIONAL JOURNAL OF STEM CELLS
(2020)
Article
Materials Science, Biomaterials
Eugene Lee, Ji-Yun Ko, Juyoung Kim, Jeong-Won Park, Songhee Lee, Gun-Il Im
BIOMATERIALS SCIENCE
(2019)