Interleukin‐4 Gene Transfection and Spheroid Formation Potentiate Therapeutic Efficacy of Mesenchymal Stem Cells for Osteoarthritis

Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs

(2019) Yun-Rak Choi et al.   Tissue Engineering and Regenerative Medicine

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

(2019) Donghyun Kang et al.   Science Translational Medicine

Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes

(2018) Miguel Tofiño-Vian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

3D-cultured human placenta-derived mesenchymal stem cell spheroids enhance ovary function by inducing folliculogenesis

(2018) Tae-Hee Kim et al.   Scientific Reports

Interleukin-1β signaling in osteoarthritis – chondrocytes in focus

(2018) Zsuzsa Jenei-Lanzl et al.   CELLULAR SIGNALLING

Knee replacement

(2018) Andrew J Price et al.   LANCET

Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model

(2017) H. Iijima et al.   OSTEOARTHRITIS AND CARTILAGE

Bioadhesive Polymersome for Localized and Sustained Drug Delivery at Pathological Sites with Harsh Enzymatic and Fluidic Environment via Supramolecular Host-Guest Complexation

(2017) Meiling Zhu et al.   Small

Osteochondral Regeneration with a Scaffold-Free Three-Dimensional Construct of Adipose Tissue-Derived Mesenchymal Stromal Cells in Pigs

(2017) Daiki Murata et al.   Tissue Engineering and Regenerative Medicine

Osteochondral Regeneration with a Scaffold-Free Three-Dimensional Construct of Adipose Tissue-Derived Mesenchymal Stromal Cells in Pigs

(2017) Daiki Murata et al.   Tissue Engineering and Regenerative Medicine

Methods Used to Evaluate Pain Behaviors in Rodents

(2017) Jennifer R. Deuis et al.   Frontiers in Molecular Neuroscience

Traumatic osteoarthritis-induced persistent mechanical hyperalgesia in a rat model of anterior cruciate ligament transection plus a medial meniscectomy

(2017) Hsiao-Chien Tsai et al.   Journal of Pain Research

Culture-expanded allogenic adipose tissue-derived stem cells attenuate cartilage degeneration in an experimental rat osteoarthritis model

(2017) Li Mei et al.   PLoS One

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review

(2016) Julien Freitag et al.   BMC MUSCULOSKELETAL DISORDERS

The effect of pro-inflammatory cytokines on immunophenotype, differentiation capacity and immunomodulatory functions of human mesenchymal stem cells

(2016) Arash Pourgholaminejad et al.   CYTOKINE

Small spheroids of adipose-derived stem cells with time-dependent enhancement of IL-8 and VEGF-A secretion

(2016) Yuichi Furuhata et al.   GENES TO CELLS

Carnosol ameliorates monosodium iodoacetate-induced osteoarthritis by targeting NF-κB and Nrf-2 in primary rat chondrocytes

(2016) Jun Wang et al.   Journal of Applied Biomedicine

Regeneration of articular cartilage using adipose stem cells

(2016) Gun-Il Im   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats

(2016) N. Ozeki et al.   OSTEOARTHRITIS AND CARTILAGE

In vitro models for the study of osteoarthritis

(2016) Craig I. Johnson et al.   VETERINARY JOURNAL

In vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model

(2016) Meng Li et al.   Stem Cell Research & Therapy

The Relationship between the Bcl-2/Bax Proteins and the Mitochondria-Mediated Apoptosis Pathway in the Differentiation of Adipose-Derived Stromal Cells into Neurons

(2016) Quanquan Wang et al.   PLoS One

Graphene Oxide Flakes as a Cellular Adhesive: Prevention of Reactive Oxygen Species Mediated Death of Implanted Cells for Cardiac Repair

(2015) Jooyeon Park et al.   ACS Nano

Cell Therapy with G-CSF-Mobilized Stem Cells in a Rat Osteoarthritis Model

(2015) Ming-Wei Deng et al.   CELL TRANSPLANTATION

Intratunical Injection of Genetically Modified Adipose Tissue‐Derived Stem Cells with Human Interferon α‐2b for Treatment of Erectile Dysfunction in a Rat Model of Tunica Albugineal Fibrosis

(2015) Ahmet Gokce et al.   Journal of Sexual Medicine

Detection of early cartilage damage using targeted nanosomes in a post-traumatic osteoarthritis mouse model

(2015) Hongsik Cho et al.   Nanomedicine-Nanotechnology Biology and Medicine

Interleukin-1 function and role in rheumatic disease

(2015) Georg Schett et al.   Nature Reviews Rheumatology

Current Progress in Stem Cell-Based Gene Therapy for Articular Cartilage Repair

(2015) Janina Frisch et al.   Current Stem Cell Research & Therapy

Dual Roles of Graphene Oxide in Chondrogenic Differentiation of Adult Stem Cells: Cell-Adhesion Substrate and Growth Factor-Delivery Carrier

(2014) Hee Hun Yoon et al.   ADVANCED FUNCTIONAL MATERIALS

Enhanced angiogenic effect of adipose-derived stromal cell spheroid with low-level light therapy in hind limb ischemia mice

(2014) In-Su Park et al.   BIOMATERIALS

Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Matrix-Degrading Enzymes In Vitro

(2014) Elisa Assirelli et al.   PLoS One

Cartilage Regeneration by Chondrogenic Induced Adult Stem Cells in Osteoarthritic Sheep Model

(2014) Chinedu C. Ude et al.   PLoS One

Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial

(2014) Chris Hyunchul Jo et al.   STEM CELLS

Stimulation of Chondrogenic Differentiation of Mesenchymal Stem Cells

(2014) Da-Ae Yu et al.   International Journal of Stem Cells

Characterization of Mesenchymal Stem Cells Derived from Rat Bone Marrow and Adipose Tissue: A Comparative Study

(2014) Ahmed Lotfy et al.   International Journal of Stem Cells

Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis

(2013) Erin Teeple et al.   AAPS Journal

Long-Term Detection of Human Adipose-Derived Mesenchymal Stem Cells After Intraarticular Injection in SCID Mice

(2013) Karine Toupet et al.   ARTHRITIS AND RHEUMATISM

Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis

(2013) Yong-Gon Koh et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

3D co-culturing model of primary pancreatic islets and hepatocytes in hybrid spheroid to overcome pancreatic cell shortage

(2013) Yesl Jun et al.   BIOMATERIALS

Altered Spinal MicroRNA-146a and the MicroRNA-183 Cluster Contribute to Osteoarthritic Pain in Knee Joints

(2013) Xin Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1βin Osteoarthritic Chondrocytes

(2013) Julia Platas et al.   MEDIATORS OF INFLAMMATION

Towards a mechanism-based approach to pain management in osteoarthritis

(2013) Anne-Marie Malfait et al.   Nature Reviews Rheumatology

Osteoarthritis pain mechanisms: basic studies in animal models

(2013) R.-X. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis

(2013) Marie Maumus et al.   Stem Cell Research

Optimal Formation of Genetically Modified and Functional Pancreatic Islet Spheroids by Using Hanging-Drop Strategy

(2013) H.J. Kim et al.   TRANSPLANTATION PROCEEDINGS

Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model

(2013) Giovanna Desando et al.   ARTHRITIS RESEARCH & THERAPY

An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids

(2012) Takahisa Anada et al.   BIOMATERIALS

Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro

(2012) Liping Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis

(2012) Yong-Gon Koh et al.   KNEE

Epidemiology of Meniscal Injury Associated With ACL Tears in Young Athletes

(2012) Kelly G. Kilcoyne et al.   ORTHOPEDICS

Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development

(2012) C. Pauli et al.   OSTEOARTHRITIS AND CARTILAGE

Mesenchymal Stem Cells: Mechanisms of Inflammation

(2011) Nora G. Singer et al.   Annual Review of Pathology-Mechanisms of Disease

Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells

(2011) Suk Ho Bhang et al.   BIOMATERIALS

Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential

(2011) Priya R. Baraniak et al.   CELL AND TISSUE RESEARCH

The epidemiology of osteoarthritis in Asia

(2011) Marlene FRANSEN et al.   International Journal of Rheumatic Diseases

Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin

(2011) Scott D. Olson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Persistent pain after joint replacement: Prevalence, sensory qualities, and postoperative determinants

(2011) Vikki Wylde et al.   PAIN

Hyaline Cartilage Regeneration by Combined Therapy of Microfracture and Long-Term Bone Morphogenetic Protein-2 Delivery

(2011) Hee Seok Yang et al.   TISSUE ENGINEERING PART A

Chondrocyte innate immune MyD88-dependent signaling drives pro-catabolic effects of the endogenous TLR2/TLR4 ligands LMW-HA and HMGB1

(2010) Ru Liu-Bryan et al.   ARTHRITIS AND RHEUMATISM

Treatment of osteoarthritis with infrapatellar fat pad derived mesenchymal stem cells in Rabbit

(2010) F.S. Toghraie et al.   KNEE

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

(2010) T. J. Bartosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

(2009) Carl R. Flannery et al.   ARTHRITIS AND RHEUMATISM

Patient Satisfaction after Total Knee Arthroplasty: Who is Satisfied and Who is Not?

(2009) Robert B. Bourne et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells

(2009) Ryota Kojima et al.   LAB ON A CHIP

Dynamic Three-Dimensional Culture Methods Enhance Mesenchymal Stem Cell Properties and Increase Therapeutic Potential

(2009) Jessica E. Frith et al.   TISSUE ENGINEERING PART C-METHODS

Anoikis: A necessary death program for anchorage-dependent cells

(2008) Paola Chiarugi et al.   BIOCHEMICAL PHARMACOLOGY

Optimization of a gene electrotransfer method for mesenchymal stem cell transfection

(2008) E Ferreira et al.   GENE THERAPY

Gene therapy progress and prospects: synthetic polymer-based systems

(2008) D Schaffert et al.   GENE THERAPY

Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints

(2008) M. Yorimitsu et al.   OSTEOARTHRITIS AND CARTILAGE

Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix

(2008) Hazel Tapp et al.   ARTHRITIS RESEARCH & THERAPY

A novel electroporation method using a capillary and wire-type electrode

(2007) Jeong Ah Kim et al.   BIOSENSORS & BIOELECTRONICS