Journal
TETRAHEDRON LETTERS
Volume 58, Issue 12, Pages 1151-1155Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.02.005
Keywords
Gorgonian-derived fungus; Aspergillus sp.; Peptide; Antiviral
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Funding
- Natural Science Foundation of China [81673326, 41376160]
- Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]
- Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]
- National Marine Public Welfare Research Project of China [201305017]
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A new cyclic pentapeptide and three new linear peptides, namely, aspergillipeptides D-G (1-4), were isolated from a culture broth of marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were confirmed by Marfey's method. Compounds 1 and 2 showed evident antiviral activity against herpes simplex virus type 1 (HSV-1) with IC50 values of 9.5 and 19.8 mu M under their non-cytotoxic concentrations against a Vero cell line, respectively, and 1 also had antiviral activity against acyclovir-resistant clinical isolates of HSV-1. (C) 2017 Elsevier Ltd. All rights reserved.
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