Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp SCSIO 41501

A new cyclic pentapeptide and three new linear peptides, namely, aspergillipeptides D-G (1-4), were isolated from a culture broth of marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were confirmed by Marfey's method. Compounds 1 and 2 showed evident antiviral activity against herpes simplex virus type 1 (HSV-1) with IC50 values of 9.5 and 19.8 mu M under their non-cytotoxic concentrations against a Vero cell line, respectively, and 1 also had antiviral activity against acyclovir-resistant clinical isolates of HSV-1. (C) 2017 Elsevier Ltd. All rights reserved.