Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, Michael E. Spurlock, John C. Kube, Xiang Z. Li, Stephen B. Smith
Summary: The study revealed that lubabegron fumarate is highly selective for the beta(3)-adrenergic receptor subtype and has minimal agonistic activity at the beta(2)-adrenergic receptor. Differences in mRNA expression levels of beta(1)-, beta(2)-, and beta(3)-AR were observed between subcutaneous and intramuscular adipose tissues. The response to beta-adrenergic ligands, especially agonists for the beta(1)- and beta(3)-receptor subtypes, was found to be lower in intramuscular adipose tissue compared to subcutaneous adipose tissue.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Takefumi Kimura, Sai P. Pydi, Lei Wang, Dhanush Haspula, Yinghong Cui, Huiyan Lu, Gabriele M. Koenig, Evi Kostenis, Gregory R. Steinberg, Oksana Gavrilova, Juergen Wess
Summary: This study found that by activating adipocyte G(q) signaling, the increased lipolysis in obese individuals can be prevented, leading to improved glucose and lipid homeostasis. This has important implications for the development of novel anti-diabetic drugs based on GPCR.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Eric D. Queathem, Rebecca J. Welly, Laura M. Clart, Candace C. Rowles, Hunter Timmons, Maggie Fitzgerald, Peggy A. Eichen, Dennis B. Lubahn, Victoria J. Vieira-Potter
Summary: The activation of Beta-3 adrenergic receptors by CL improves systemic and adipose tissue-specific metabolism in both sexes, with sex differences observed in the specific effects of CL on white adipose tissue. Furthermore, CL affects estrogen signaling by upregulating estrogen receptor beta across sexes and depots.
Article
Biochemistry & Molecular Biology
Alexandre Pinel, Jean-Paul Rigaudiere, Beatrice Morio, Frederic Capel
Summary: The study showed that continuous intake of EPA-rich fish oil for three generations could reduce activation of inflammatory processes, maintain metabolic homeostasis, and decrease dysregulation of cholesterol metabolism and mitochondrial functions in response to an obesogenic diet. Continuous intake of long chain n-3 PUFA may be beneficial in preventing the effects of energy-dense, nutrient-poor foods.
Article
Pharmacology & Pharmacy
Alessandro De Stefano, Francesca Schinzari, Nicola Di Daniele, Giuseppe Sica, Paolo Gentileschi, Giuseppina Vizioli, Carmine Cardillo, Manfredi Tesauro
Summary: Mirabegron induces endothelium-independent vasorelaxation in arteries from visceral adipose tissue by antagonizing alpha(1)-adrenoceptors, rather than activating beta(3)-adrenoceptors.
VASCULAR PHARMACOLOGY
(2022)
Article
Fisheries
Chaobin Qin, Wenli Zhao, Xiao Yan, Guokun Yang, Liping Yang, Ronghua Lu, Daming Pi, Guoxing Nie
Summary: The study suggests that adiponectin plays critical roles in regulating glucose metabolism in fish. It promotes glycolysis, gluconeogenesis, and glycogen synthesis, increases glycogen content in the hepatopancreas, and reduces basal blood glucose level. Adiponectin A and adiponectin B have opposite regulatory effects on glucose uptake.
AQUACULTURE NUTRITION
(2022)
Article
Endocrinology & Metabolism
Hani Zaidi, Tonje Aksnes, Sissel akra, Heidi B. Eggesbo, Rune Byrkjeland, Ingebjorg Seljeflot, Trine B. Opstad
Summary: This study found that increased amount of adipose tissue (AT) is associated with lower levels of adiponectin and increased levels of TNF alpha AT expression. Circulating adiponectin is inversely correlated with insulin sensitivity, insulin, C-peptide, and waist circumference.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiahan Xie, Huimin Liu, Wandi Yin, Sitong Ge, Zhibo Jin, Mingzhu Zheng, Dan Cai, Meihong Liu, Jingsheng Liu
Summary: This study found that zeaxanthin (ZEA) induces structural and metabolic remodeling of lipid droplets (LDs) by activating beta 3-adrenergic receptor (β3-AR) signaling and enhancing PLIN5-mediated LD-mitochondrion interactions, thereby enhancing oxidative capacity and potentially serving as a nutritional intervention for the prevention and treatment of obesity and associated metabolic syndrome.
Article
Cell Biology
Shree Bose, Qiang Huang, Yunhan Ma, Lihua Wang, Grecia O. Rivera, Yunxin Ouyang, Regina Whitaker, Rebecca A. Gibson, Christopher D. Kontos, Andrew Berchuck, Rebecca A. Previs, Xiling Shen
Summary: Ovarian cancer cells in the omental microenvironment experience oxidative stress and adapt to this challenge through metabolic reprogramming. Inhibition of the key enzyme G6PD in the pentose phosphate pathway reduces tumor burden in OC.
Article
Clinical Neurology
Marine Tournissac, Tra-My Vu, Nika Vrabic, Clara Hozer, Cyntia Tremblay, Koralie Melancon, Emmanuel Planel, Fabien Pifferi, Frederic Calon
Summary: The administration of beta 3AR agonist was found to improve body weight, glucose metabolism, and brown adipose tissue thermogenesis in aged mice, while also increasing recognition index and decreasing insoluble A beta 42/A beta 40 ratio.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Immunology
Michal Konwerski, Agnieszka Gromadka, Adam Arendarczyk, Marta Koblowska, Roksana Iwanicka-Nowicka, Radoslaw Wilimski, Pawel Czub, Krzysztof Jerzy Filipiak, Piotr Hendzel, Piotr Zielenkiewicz, Grzegorz Opolski, Aleksandra Gasecka, Tomasz Mazurek
Summary: Perivascular release of inflammatory mediators may accelerate coronary lesion formation and contribute to plaque instability. The study revealed altered gene expression in PCAT of CAD patients, with upregulation of genes involved in inflammation and atherosclerosis, and downregulation of genes related to cardiac ischemia, remodeling, platelet function, and mitochondrial function. This suggests that genes in PCAT may play a role in CAD development and progression.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Miguel Chirivi, C. Javier Rendon, Madison N. Myers, Crystal M. Prom, Sambit Roy, Aritro Sen, Adam L. Lock, G. Andres Contreras
Summary: The exposure to endotoxin can enhance lipolysis and reduce insulin sensitivity in adipose tissue, leading to decreased sensitivity of adipocytes to the antilipolytic action of insulin.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Lidan Zhao, Honglin Jiang
Summary: The inhibitory effect of growth hormone (GH) on adipose tissue growth is achieved partially by stimulating lipolysis. GH injection in GH-deficient lit/lit mice resulted in a reduction in adipose tissue size. However, GH does not directly affect basal or isoproterenol-induced lipolysis or enhance beta-adrenergic receptors-mediated lipolysis in adipose tissue or adipocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adam Prabata, Koji Ikeda, Elda Putri Rahardini, Ken-Ichi Hirata, Noriaki Emoto
Summary: The study demonstrates that GPNMB negatively regulates macrophage inflammatory capacities and ameliorates WAT inflammation in obesity, making it a promising therapeutic target for metabolic disorders associated with obesity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Maria Luengo-Mateos, Antia Gonzalez-Vila, Nathalia Romanelli Vicente Dragano, Nataliia Ohinska, Maria Silveira-Loureiro, Marco Gonzalez-Dominguez, Anxela Estevez-Salguero, Paula Novelle-Rodriguez, Miguel Lopez, Olga Barca-Mayo
Summary: Here, we show that hypothalamic astrocytic BMAL1 plays a role in computing cyclic metabolic information for optimizing energetic resources in a sexually dimorphic manner. Knockdown of BMAL1 in female astrocytes leads to negative energy balance and alters basal metabolic cycles without affecting circadian locomotor activity. Furthermore, female mice with BMAL1 knockdown in astrocytes exhibit a male-like metabolic obese phenotype when fed a high-fat diet. These findings highlight the importance of astrocytic BMAL1 in the regulation of energy homeostasis and its potential implications in the physiopathology of obesity and related comorbidities.
Article
Cell Biology
P. Chomanic, L. Karailievova, J. Graban, D. Jezova
Summary: Research suggests that endogenous opioid peptides may act through delta-opioid receptors to play a role in neuroprotection against stress-induced changes in brain plasticity and stress hormone release. Specifically, treatment with the delta-opioid receptor antagonist naltrindole was found to exacerbate the stress-induced rise in aldosterone concentrations and decrease hippocampal BDNF gene expression in rats under stress conditions.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zuzana Romanova, Natasa Hlavacova, Daniela Jezova
Summary: Chronic stress and adrenocortical hormone release have an impact on the development and treatment outcome of mental disorders. This review focuses on the modulation of cortisol and aldosterone secretion by antipsychotic drugs under stress and non-stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Eliyahu Dremencov, Daniil Grinchii, Katarina Hrivikova, Maxim Lapshin, Maria Komelkova, Jan Graban, Agnesa Puhova, Olga Tseilikman, Vadim Tseilikman, Daniela Jezova
Summary: Exposure to predator scent (PS) increases the activity of 5-HT neurons and decreases the concentrations of corticosterone and aldosterone in the blood. The mechanisms leading to increased excitability of 5-HT neurons in rats who experienced repeated PS were evaluated.
PHARMACOLOGICAL REPORTS
(2022)
Article
Environmental Sciences
Aneta Bednarova, Natasa Hlavacova, Jan Pecenak
Summary: This study investigated the motives and factors related to suicidal behavior in 121 hospitalized patients with intentional self-harm. The results showed that patients with affective disorder had a higher rate of suicide attempts, while patients with personality disorders had a higher rate of non-suicidal self-injurious behavior. Living alone and the absence of social support increased the likelihood of suicide attempts. Qualitative analysis of patients' statements revealed significant differences in motives for suicidal behavior.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Z. Romanova, L. Karailievova, A. Garafova, N. Hlavacova, H. Oravcova, D. Jezova
Summary: The aim of this study was to investigate the association between the neuroendocrine state of mothers and their children under real-life stress conditions (COVID-19 pandemic) by measuring testosterone and cortisol concentrations in hair. The results showed significantly higher cortisol and testosterone concentrations in mothers compared to their children. While the cortisol concentrations did not support the hypothesis, the testosterone measurements in hair revealed a positive correlation between mothers and their children, especially in women with intense subjective feelings of anger. This suggests that chronic testosterone secretion may reflect the association between the neuroendocrine function of mothers and their children under real-life stress conditions.
PSYCHONEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Harald Murck, Lisa Lehr, Daniela Jezova
Summary: An abundance of knowledge has been collected on neuroendocrine parameters in major depression, with the hypothalamic-pituitary-adrenocortical (HPA) axis and its regulation of cortisol receiving extensive study. However, attempts to pharmacologically target the HPA axis for treating major depression have been unsuccessful. This review focuses on the role of aldosterone, released by adrenocorticotropic hormone and angiotensin, and the mineralocorticoid receptor (MR) in depression. Depressed patients, especially those with atypical depression, show signs of central hyperactivation of the aldosterone sensitive MR, potentially due to reactive aldosterone release induced by low blood pressure and low peripheral MR sensitivity.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Elizabeth A. Shirtcliff, Daniela Jezova, Blazej Misiak, Urs Nater, Heather Brenhouse
PSYCHONEUROENDOCRINOLOGY
(2023)
Editorial Material
Behavioral Sciences
Kristin L. Gosselink, Jorge A. Sierra Fonseca, Daniela Jezova
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Sofia Elisa Alzuri, Nicolas Matias Rosas, Natasa Hlavacova, Daniela Jezova, Beata Fuchsova
Summary: The neuronal membrane glycoprotein M6a (GPM6A) plays a role in neuronal remodeling and plasticity. Chronic stress can regulate the expression of Gpm6a through miR-124-mediated impact on Hdac5 and Mef2c. BDNF can activate Gpm6a expression.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Eliyahu Dremencov, Daniil Grinchii, Zuzana Romanova, Pavol Chomanic, Lubica Lacinova, Daniela Jezova
Summary: Chronic treatment with the non-peptide agonist SNC80 increases excitability of hippocampal glutamate and ventral tegmental area dopamine neurons, leading to anxiolytic effects. However, it does not affect the ability to cope with stress or habituation processes in a novel environment.
PHARMACOLOGICAL REPORTS
(2023)
Article
Health Care Sciences & Services
Aneta Bednarova, Viera Habalova, Silvia Farkasova Iannaccone, Ivan Tkac, Dominika Jarcuskova, Michaela Krivosova, Matteo Marcatili, Natasa Hlavacova
Summary: Since suicide and suicidal behavior are highly heritable, identifying genetic markers for predicting suicide risk is crucial in clinical practice. This case-control study explored the associations between completed suicide and genetic polymorphisms in BDNF (rs6265, rs962369), SLC6A4 (5-HTTLPR), and FTO (rs9939609) genes, considering sex and BMI. The findings revealed a significant association between BDNF rs962369 variant and completed suicide, particularly in males. Furthermore, an association between BDNF rs962369 variant and BMI was observed, indicating that heterozygotes with the TC genotype had lower average BMI. The FTO polymorphism did not influence BMI in Slovak suicide completers, but an inverse association between BMI and completed suicide was found.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Marie Obdrzalkova, Libor Ustohal, Natasa Hlavacova, Michaela Mayerova, Eva Ceskova, Tomas Kasparek, Daniela Jezova
Summary: This pilot study aimed to investigate whether dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treatment outcome. The study revealed that lower baseline aldosterone and higher baseline cortisol concentrations may predict a more favorable treatment outcome for patients with the first episode of psychosis.