Article
Medicine, General & Internal
Elena Izkhakov, Yacov Shacham, Merav Serebro, Iris Yaish, Yonit Marcus, Gabi Shefer, Karen Tordjman, Yona Greenman, Naftali Stern, Tomer Ziv-Baran
Summary: This study examined the effect of monotherapy with the PSCK9 inhibitor evolocumab on high-risk cardiovascular patients, showing significant reductions in lipid profile and aldosterone levels after 3 months of treatment. The findings suggest that reductions in aldosterone secretion under evolocumab therapy may be associated with decreased cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Katiuska Satue, Esterina Fazio, Ana Munoz, Pietro Medica
Summary: This study investigated the physiological mechanisms involved in electrolyte balance during the periovulatory period in cycling mares. The simultaneous increase in ACTH, CORT, and ALD prior to ovulation suggests the involvement of the adrenocortical pituitary axis in ovulatory mechanisms. It also found that the pituitary adrenocortical response and ALD may be involved in ovulatory mechanisms without a direct relation with electrolyte pattern.
Article
Plant Sciences
Jiayuan Li, Jiahe Yu, Jianyou Guo, Jinfeng Liu, Guohui Wan, Xiaojia Wei, Xue Yang, Jinli Shi
Summary: The combination of Nardostachys jatamansi (NJ) and levodopa has a synergistic effect in alleviating Parkinson's disease (PD), which is achieved by activating the Nrf2 pathway and inhibiting oxidative stress and the NLRP3 pathway.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Christina Tatsi, Andrea G. Maria, Cole Malloy, Lin Lin, Edra London, Nick Settas, Chelsi Flippo, Meg Keil, Fady Hannah-Shmouni, Dax A. Hoffman, Constantine A. Stratakis
Summary: This study reports a case of a 10-year-old child with Cushing syndrome due to bilateral adrenocortical hyperplasia, involving the KCNJ5 gene, without identifiable gene defects. The results show that the KCNJ5 pathogenic variant affects the conductance of the Kir3.4 channel, differing from those causing primary aldosteronism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Marie Obdrzalkova, Libor Ustohal, Natasa Hlavacova, Michaela Mayerova, Eva Ceskova, Tomas Kasparek, Daniela Jezova
Summary: This pilot study aimed to investigate whether dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treatment outcome. The study revealed that lower baseline aldosterone and higher baseline cortisol concentrations may predict a more favorable treatment outcome for patients with the first episode of psychosis.
Article
Peripheral Vascular Disease
Yujiro Maeoka, Xiao-Tong Su, Wen-Hui Wang, Xin-Peng Duan, Avika Sharma, Na Li, Olivier Staub, James A. McCormick, David H. Ellison
Summary: The study suggests that MR is activated in the absence of aldosterone in DCT2 and partially CCD, indicating that glucocorticoid binding to MR may preserve sodium homeostasis in DCT2.
Review
Medicine, Research & Experimental
Omnia Azmy Nabeh
Summary: Premenstrual disorders (PMDs), including premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), are characterized by physical and psychological changes during the luteal phase of the menstrual cycle. The role of gut microbiota (GM) in PMDs is supported by emerging evidence, as GM has a direct secretory function and can influence hormonal, neurotransmitters, and bioactive compounds secretion and activity. The bidirectional relation between GM and steroid hormones, as well as the impact of diet, drugs, and inflammation on both GM and PMDs, highlight the need for further studies to determine the actual role of GM and explore the potential of probiotics and prebiotics as therapeutic options.
Review
Endocrinology & Metabolism
Nada Younes, Isabelle Bourdeau, Andre Lacroix
Summary: Primary adrenal insufficiency is a rare but potentially fatal disease characterized by destruction of the adrenal cortex leading to hormone deficiencies. Patients often present with fatigue, weight loss, melanoderma, and hypotension. Diagnosis requires testing hormone levels and concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Takashi Yoneda, Yoshiyu Takeda
Summary: Aldosterone and cortisol play important roles in cardiovascular diseases and metabolic disorders. Epigenetic mechanisms control the expression of steroid hormone synthase genes, including CYP11B2 and CYP11B1, through DNA methylation. Various factors, such as angiotensin II, potassium, and low-salt diet, can regulate the expression of these genes by inducing changes in DNA methylation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chiara Sabbadin, Carlo Saccardi, Alessandra Andrisani, Amerigo Vitagliano, Loris Marin, Eugenio Ragazzi, Luciana Bordin, Guido Ambrosini, Decio Armanini
Summary: Endometriosis is a chronic inflammatory disease that is associated with pelvic pain, infertility, and increased cardiovascular risk. This study aimed to evaluate the levels of aldosterone and cortisol, as well as blood pressure values, in women with endometriosis. The results showed that there was increased biological aldosterone activity and dysregulation of the hypothalamic-pituitary-adrenal axis in early stages of endometriosis. These findings suggest new therapeutic targets for aldosterone receptor blockers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Y. Joseph Hwang, G. Caleb Alexander, Huijun An, Thomas J. Moore, Hemalkumar B. Mehta
Summary: The use of pimavanserin in patients with Parkinson's disease who are 65 or older and residing in Medicare-certified long-term care facilities is associated with an increased risk of 30-day hospitalization and higher 90-, 180-, and 365-day mortality.
Review
Biochemistry & Molecular Biology
Diana Duarte, Nuno Vale
Summary: Drug repurposing is an effective strategy to expedite the discovery of new clinical uses for already approved drugs for different diseases, with fluphenazine showing great potential in cancer therapy.
Article
Multidisciplinary Sciences
Simone Patergnani, Massimo Bonora, Selene Ingusci, Maurizio Previati, Saverio Marchi, Silvia Zucchini, Mariasole Perrone, Mariusz R. Wieckowski, Massimiliano Castellazzi, Maura Pugliatti, Carlotta Giorgi, Michele Simonato, Paolo Pinton
Summary: The study found that autophagy and mitophagy are increased in MS patients, with inhibitors of autophagy improving myelination and behavioral signs in experimental models of the disease, suggesting a causal role of autophagy in MS and potential therapeutic benefits of autophagy inhibitors like haloperidol and clozapine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Ewelina Dziurkowska, Marek Wesolowski
Summary: Cortisol, as the most important steroid hormone, strongly affects metabolism and is closely related to psychiatric disorders, serving as a potential biological marker to assist in determining the likelihood, onset, and severity of mental illnesses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Georgia Pitsava, Andrea G. Maria, Fabio R. Faucz
Summary: This review provides an overview of disorders associated with the adrenal cortex, the genetic factors implicated in these disorders, and their molecular implications. It highlights the advancements in genomic data analysis over the past decade, which have improved the diagnosis and treatment of adrenal cortical diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Z. Romanova, K. Hrivikova, I Riecansky, D. Jezova
Summary: The present study explored the relationship between hormone release and non-verbal communication under stress conditions. The findings revealed that individuals with higher stress perception showed more pronounced changes in non-verbal behavior during acute psychosocial stress situations, and these changes were associated with salivary testosterone concentrations and testosterone/cortisol ratios.
Article
Biochemistry & Molecular Biology
Henrieta Oravcova, Barbora Katrencikova, Iveta Garaiova, Zdenka Durackova, Jana Trebaticka, Daniela Jezova
Summary: Late childhood and adolescence are crucial periods of brain development vulnerable to environmental insults. This study aimed to test the effect of omega-3 fatty acid supplementation on stress hormone concentrations and daily rhythm in adolescents with depression, and explore the correlation between stress hormones and oxidative stress markers.
Article
Biochemistry & Molecular Biology
Daniil Grinchii, Marius C. Hoener, Talah Khoury, Roman Dekhtiarenko, Reyhaneh Nejati Bervanlou, Daniela Jezova, Eliyahu Dremencov
Summary: Trace amine-associated receptor 1 (TAAR1) has been identified as a potential target for future antidepressant, antipsychotic, and anti-addiction drugs. Studies have shown that TAAR1 agonists can produce antidepressant, antipsychotic, and anti-addiction behavioral effects in rodents and primates, and these effects are associated with the modulation of serotonin (5-HT) and dopamine.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
K. Hrivikova, D. Zelena, J. Graban, A. Puhova, I. Miklya, D. Balazsfi, D. Jezova
Summary: In a study on chronically stressed rats, concurrent treatment with enhancer drugs did not cause significant neuroendocrine changes, but altered gene expression in selected parameters associated with brain plasticity. The observed changes may indicate a positive influence of enhancer drugs on brain plasticity, which is important for preventing negative consequences of chronic stress and enhancing stress resilience.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Z. Romanova, L. Karailievova, A. Garafova, N. Hlavacova, H. Oravcova, D. Jezova
Summary: The aim of this study was to investigate the association between the neuroendocrine state of mothers and their children under real-life stress conditions (COVID-19 pandemic) by measuring testosterone and cortisol concentrations in hair. The results showed significantly higher cortisol and testosterone concentrations in mothers compared to their children. While the cortisol concentrations did not support the hypothesis, the testosterone measurements in hair revealed a positive correlation between mothers and their children, especially in women with intense subjective feelings of anger. This suggests that chronic testosterone secretion may reflect the association between the neuroendocrine function of mothers and their children under real-life stress conditions.
PSYCHONEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Harald Murck, Lisa Lehr, Daniela Jezova
Summary: An abundance of knowledge has been collected on neuroendocrine parameters in major depression, with the hypothalamic-pituitary-adrenocortical (HPA) axis and its regulation of cortisol receiving extensive study. However, attempts to pharmacologically target the HPA axis for treating major depression have been unsuccessful. This review focuses on the role of aldosterone, released by adrenocorticotropic hormone and angiotensin, and the mineralocorticoid receptor (MR) in depression. Depressed patients, especially those with atypical depression, show signs of central hyperactivation of the aldosterone sensitive MR, potentially due to reactive aldosterone release induced by low blood pressure and low peripheral MR sensitivity.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Elizabeth A. Shirtcliff, Daniela Jezova, Blazej Misiak, Urs Nater, Heather Brenhouse
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sofia Elisa Alzuri, Nicolas Matias Rosas, Natasa Hlavacova, Daniela Jezova, Beata Fuchsova
Summary: The neuronal membrane glycoprotein M6a (GPM6A) plays a role in neuronal remodeling and plasticity. Chronic stress can regulate the expression of Gpm6a through miR-124-mediated impact on Hdac5 and Mef2c. BDNF can activate Gpm6a expression.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Eliyahu Dremencov, Daniil Grinchii, Zuzana Romanova, Pavol Chomanic, Lubica Lacinova, Daniela Jezova
Summary: Chronic treatment with the non-peptide agonist SNC80 increases excitability of hippocampal glutamate and ventral tegmental area dopamine neurons, leading to anxiolytic effects. However, it does not affect the ability to cope with stress or habituation processes in a novel environment.
PHARMACOLOGICAL REPORTS
(2023)
Article
Health Care Sciences & Services
Aneta Bednarova, Viera Habalova, Silvia Farkasova Iannaccone, Ivan Tkac, Dominika Jarcuskova, Michaela Krivosova, Matteo Marcatili, Natasa Hlavacova
Summary: Since suicide and suicidal behavior are highly heritable, identifying genetic markers for predicting suicide risk is crucial in clinical practice. This case-control study explored the associations between completed suicide and genetic polymorphisms in BDNF (rs6265, rs962369), SLC6A4 (5-HTTLPR), and FTO (rs9939609) genes, considering sex and BMI. The findings revealed a significant association between BDNF rs962369 variant and completed suicide, particularly in males. Furthermore, an association between BDNF rs962369 variant and BMI was observed, indicating that heterozygotes with the TC genotype had lower average BMI. The FTO polymorphism did not influence BMI in Slovak suicide completers, but an inverse association between BMI and completed suicide was found.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Marie Obdrzalkova, Libor Ustohal, Natasa Hlavacova, Michaela Mayerova, Eva Ceskova, Tomas Kasparek, Daniela Jezova
Summary: This pilot study aimed to investigate whether dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treatment outcome. The study revealed that lower baseline aldosterone and higher baseline cortisol concentrations may predict a more favorable treatment outcome for patients with the first episode of psychosis.
Article
Psychology, Experimental
Alexandra Garafova, Zuzana Romanova, Henrieta Oravcova, Lubomira Izakova, Natasa Hlavacova, Daniela Jezova
Summary: The ongoing study aims to investigate the impact of post-partum maternal mood fluctuations on child development and explore the correlation between the neuroendocrine function of mothers and their neonates. The study design involves testing the hypothesis under stress and non-stress conditions in mothers and babies at different ages. Preliminary analyses indicate the feasibility of saliva sampling in neonates and reveal increased cortisol concentrations during the third trimester of pregnancy. Results also show a positive correlation between salivary cortisol values before and after a stress test in mother-infant dyads. Understanding the mechanisms involved in the mother-child relationship will facilitate the development of interventions for mothers in the early postpartum period.
