Microphysiological Human Brain and Neural Systems-on-a-Chip: Potential Alternatives to Small Animal Models and Emerging Platforms for Drug Discovery and Personalized Medicine
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Title
Microphysiological Human Brain and Neural Systems-on-a-Chip: Potential Alternatives to Small Animal Models and Emerging Platforms for Drug Discovery and Personalized Medicine
Authors
Keywords
Organ-on-a-chip, Brain-on-a-chip, Nervous system-on-a-chip, Microfluidics, 3D bioprinting, 3D cell culture
Journal
Stem Cell Reviews and Reports
Volume 13, Issue 3, Pages 381-406
Publisher
Springer Nature
Online
2017-05-10
DOI
10.1007/s12015-017-9738-0
References
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Related references
Note: Only part of the references are listed.- 3D-Printed Microfluidics
- (2016) Anthony K. Au et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Compartmental microfluidic system for studying muscle–neuron communication and neuromuscular junction maintenance
- (2016) Ariel Ionescu et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome
- (2016) G. E. Rooney et al. JOURNAL OF NEUROSCIENCE
- 3D printed nervous system on a chip
- (2016) Blake N. Johnson et al. LAB ON A CHIP
- Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems
- (2016) Fuyin Zheng et al. Small
- Functional 3D Neural Mini-Tissues from Printed Gel-Based Bioink and Human Neural Stem Cells
- (2016) Qi Gu et al. Advanced Healthcare Materials
- 3D Printed Anatomical Nerve Regeneration Pathways
- (2015) Blake N. Johnson et al. ADVANCED FUNCTIONAL MATERIALS
- 3D printing of layered brain-like structures using peptide modified gellan gum substrates
- (2015) Rodrigo Lozano et al. BIOMATERIALS
- 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways
- (2015) Peter DelNero et al. BIOMATERIALS
- Microfluidic 3D cell culture: from tools to tissue models
- (2015) Vincent van Duinen et al. CURRENT OPINION IN BIOTECHNOLOGY
- A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions
- (2015) E. E. Zahavi et al. JOURNAL OF CELL SCIENCE
- Microengineered peripheral nerve-on-a-chip for preclinical physiological testing
- (2015) Renee M. Huval et al. LAB ON A CHIP
- 3D printed microfluidics for biological applications
- (2015) Chee Meng Benjamin Ho et al. LAB ON A CHIP
- Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease
- (2015) JiSoo Park et al. LAB ON A CHIP
- Organs-on-chips at the frontiers of drug discovery
- (2015) Eric W. Esch et al. NATURE REVIEWS DRUG DISCOVERY
- Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
- (2015) Ana Perestrelo et al. SENSORS
- Engineering-Aligned 3D Neural Circuit in Microfluidic Device
- (2015) Seokyoung Bang et al. Advanced Healthcare Materials
- A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip
- (2015) Sudhir P. Deosarkar et al. PLoS One
- 3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs
- (2014) David B. Kolesky et al. ADVANCED MATERIALS
- Incidence, Prevalence, Costs, and Impact on Disability of Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury, Traumatic Brain Injury, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis, Limb Loss, and Back Pain
- (2014) Vincent Y. Ma et al. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
- Biological and medical applications of a brain-on-a-chip
- (2014) David Pamies et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Minimum conditions for the induction of cortical spreading depression in brain slices
- (2014) Yujie T. Tang et al. JOURNAL OF NEUROPHYSIOLOGY
- A two-compartment organotypic model of mammalian peripheral nerve repair
- (2014) Rezina Siddique et al. JOURNAL OF NEUROSCIENCE METHODS
- A microfluidic based in vitro model of synaptic competition
- (2014) Ainsley Coquinco et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons
- (2014) Xi Lu et al. Molecular Neurodegeneration
- The present and future role of microfluidics in biomedical research
- (2014) Eric K. Sackmann et al. NATURE
- 3D bioprinting of tissues and organs
- (2014) Sean V Murphy et al. NATURE BIOTECHNOLOGY
- Block-Cell-Printing for live single-cell printing
- (2014) K. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bioengineered functional brain-like cortical tissue
- (2014) M. D. Tang-Schomer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sensory axon guidance with semaphorin 6A and nerve growth factor in a biomimetic choice point model
- (2014) J Lowry Curley et al. Biofabrication
- Engineering a functional neuro-muscular junction model in a chip
- (2014) Ziqiu Tong et al. RSC Advances
- Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three-Dimensional Extracellular Matrix
- (2014) Yoojin Shin et al. Advanced Healthcare Materials
- β-Amyloid is transmitted via neuronal connections along axonal membranes
- (2013) Ha-Lim Song et al. ANNALS OF NEUROLOGY
- Size-controllable networked neurospheres as a 3D neuronal tissue model for Alzheimer's disease studies
- (2013) Yoon Jung Choi et al. BIOMATERIALS
- Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D
- (2013) Jennifer Laurent et al. BMC CANCER
- Efficient Retrograde Transport of Pseudorabies Virus within Neurons Requires Local Protein Synthesis in Axons
- (2013) Orkide O. Koyuncu et al. Cell Host & Microbe
- Integration of microfluidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration
- (2013) Kwang Ho Lee et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Microfluidic primary culture model of the lower motor neuron–neuromuscular junction circuit
- (2013) Katherine A. Southam et al. JOURNAL OF NEUROSCIENCE METHODS
- Selective pharmacological manipulation of cortical–thalamic co-cultures in a dual-compartment device
- (2013) Thirukumaran T. Kanagasabapathi et al. JOURNAL OF NEUROSCIENCE METHODS
- A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments
- (2013) Jaewon Park et al. JOURNAL OF NEUROSCIENCE METHODS
- Control of neural network patterning using collagen gel photothermal etching
- (2013) Aoi Odawara et al. LAB ON A CHIP
- Formation of microvascular networks in vitro
- (2013) John P Morgan et al. Nature Protocols
- Spheroid culture as a tool for creating 3D complex tissues
- (2013) Eelco Fennema et al. TRENDS IN BIOTECHNOLOGY
- Overflow Microfluidic Networks: Application to the Biochemical Analysis of Brain Cell Interactions in Complex Neuroinflammatory Scenarios
- (2012) Fabio Bianco et al. ANALYTICAL CHEMISTRY
- Chronic Excitotoxin-Induced Axon Degeneration in a Compartmented Neuronal Culture Model
- (2012) Katherine A Hosie et al. ASN Neuro
- Structural and molecular micropatterning of dual hydrogel constructs for neural growth models using photochemical strategies
- (2012) Elaine L. Horn-Ranney et al. BIOMEDICAL MICRODEVICES
- Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures
- (2012) Ju Hun Yeon et al. BIOMEDICAL MICRODEVICES
- BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
- (2012) L. M. Griep et al. BIOMEDICAL MICRODEVICES
- Three-dimensional cell culture: the missing link in drug discovery
- (2012) Susan Breslin et al. DRUG DISCOVERY TODAY
- Functional connectivity and dynamics of cortical–thalamic networks co-cultured in a dual compartment device
- (2012) Thirukumaran T Kanagasabapathi et al. Journal of Neural Engineering
- A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons
- (2012) Xi Lu et al. JOURNAL OF NEUROSCIENCE METHODS
- Multi-compartment neuron–glia co-culture platform for localized CNS axon–glia interaction study
- (2012) Jaewon Park et al. LAB ON A CHIP
- Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices
- (2012) Philip J. Kitson et al. LAB ON A CHIP
- Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
- (2012) Ross Booth et al. LAB ON A CHIP
- SyM-BBB: a microfluidic blood brain barrier model
- (2012) Balabhaskar Prabhakarpandian et al. LAB ON A CHIP
- A modular approach to create a neurovascular unit-on-a-chip
- (2012) Anil Kumar H. Achyuta et al. LAB ON A CHIP
- Microfluidic Chips for In Vivo Imaging of Cellular Responses to Neural Injury in Drosophila Larvae
- (2012) Mostafa Ghannad-Rezaie et al. PLoS One
- Alphaherpesvirus axon-to-cell spread involves limited virion transmission
- (2012) M. P. Taylor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Co-pathological connected primary neurons in a microfluidic device for alzheimer studies
- (2011) Anja Kunze et al. BIOTECHNOLOGY AND BIOENGINEERING
- FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy
- (2011) S. Kehoe et al. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
- Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers
- (2011) Jean-Michel Peyrin et al. LAB ON A CHIP
- Psychiatric and neurologic aspects of war: an overview and perspective
- (2010) JoAnn Difede et al. Annals of the New York Academy of Sciences
- Co-culture of neurons and glia in a novel microfluidic platform
- (2010) Devi Majumdar et al. JOURNAL OF NEUROSCIENCE METHODS
- Building and manipulating neural pathways with microfluidics
- (2010) Yevgeny Berdichevsky et al. LAB ON A CHIP
- Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices
- (2010) Larry J. Millet et al. LAB ON A CHIP
- Microfluidic Local Perfusion Chambers for the Visualization and Manipulation of Synapses
- (2010) Anne M. Taylor et al. NEURON
- The Path to Personalized Medicine
- (2010) Margaret A. Hamburg et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nanowire transistor arrays for mapping neural circuits in acute brain slices
- (2010) Q. Qing et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reconstituting Organ-Level Lung Functions on a Chip
- (2010) D. Huh et al. SCIENCE
- 3D printing based on imaging data: review of medical applications
- (2010) F. Rengier et al. International Journal of Computer Assisted Radiology and Surgery
- Microfluidic compartmentalized co-culture platform for CNS axon myelination research
- (2009) Jaewon Park et al. BIOMEDICAL MICRODEVICES
- Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport
- (2009) Will Stoothoff et al. JOURNAL OF NEUROCHEMISTRY
- Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates
- (2009) Gregory J. Brewer et al. JOURNAL OF NEUROSCIENCE METHODS
- Three-dimensional micro-electrode array for recording dissociated neuronal cultures
- (2009) Katherine Musick et al. LAB ON A CHIP
- Chamber and microfluidic probe for microperfusion of organotypic brain slices
- (2009) Arthur Queval et al. LAB ON A CHIP
- Differentiation of Neural Progenitor Cells in a Microfluidic Chip-Generated Cytokine Gradient
- (2009) Joong Yull Park et al. STEM CELLS
- Modeling the Nonlinear Properties of the in vitro Hippocampal Perforant Path-Dentate System Using Multielectrode Array Technology
- (2008) A. Dimoka et al. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
- Three-dimensional neural constructs: a novel platform for neurophysiological investigation
- (2008) Hillary R Irons et al. Journal of Neural Engineering
- Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture
- (2008) Bradley J. Dworak et al. LAB ON A CHIP
- The coming acceleration of global population ageing
- (2008) Wolfgang Lutz et al. NATURE
- Causal Measures of Structure and Plasticity in Simulated and Living Neural Networks
- (2008) Alex J. Cadotte et al. PLoS One
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