Activation of the PI3K/AKT Pathway in Merkel Cell Carcinoma

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

(2011) Masahiro Shuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens

(2010) R. Houben et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma

(2009) S. A. Aziz et al.   CLINICAL CANCER RESEARCH

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma

(2009) Supriya Gaitonde et al.   Pigment Cell & Melanoma Research

Quantitation of Human Seroresponsiveness to Merkel Cell Polyomavirus

(2009) Diana V. Pastrana et al.   PLoS Pathogens

Merkel cell carcinoma

(2008) J. C. Becker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

p14ARF Hypermethylation Is Common but INK4a-ARF Locus or p53 Mutations Are Rare in Merkel Cell Carcinoma

(2008) Anita Lassacher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Array-CGH Reveals Recurrent Genomic Changes in Merkel Cell Carcinoma Including Amplification of L-Myc

(2008) Kelly G. Paulson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MC Polyomavirus Is Frequently Present in Merkel Cell Carcinoma of European Patients

(2008) Jürgen C. Becker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interaction between Simian Virus 40 Large T Antigen and Insulin Receptor Substrate 1 Is Disrupted by the K1 Mutation, Resulting in the Loss of Large T Antigen-Mediated Phosphorylation of Akt

(2008) Y. Yu et al.   JOURNAL OF VIROLOGY

AKT1 E17K in human solid tumours

(2008) F E Bleeker et al.   ONCOGENE

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

(2008) M. Shuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE