Surface Plasmon Resonance Sensing of Biorecognition Interactions within the Tumor Suppressor p53 Network

Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis

(2016) Senem Aykul et al.   ANALYTICAL BIOCHEMISTRY

Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family

(2016) Sebastian Kehrloesser et al.   CELL DEATH AND DIFFERENTIATION

MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance

(2016) Salvatore Cannistraro et al.   International Journal of Nanomedicine

Molecular design and validation of halogen bonding orthogonal to hydrogen bonding in breast cancer MDM2–peptide complex

(2016) Anzhong Huang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Phase I trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors: A Pediatric Brain Tumor Consortium Study

(2016) Rishi R. Lulla et al.   NEURO-ONCOLOGY

Flexibility is important for inhibition of the MDM2/p53 protein–protein interaction by cyclic β-hairpins

(2016) Emma Danelius et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rescuing the guardian of the genome

(2016) R. F. Service   SCIENCE

The dominant-negative interplay between p53, p63 and p73: A family affair

(2016) Olivier Billant et al.   Oncotarget

A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53

(2016) John Bechill et al.   PLoS One

Structural basis of how stress-induced MDMX phosphorylation activates p53

(2015) X Chen et al.   ONCOGENE

Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding

(2015) GuoZhen Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications

(2015) Hoang Nguyen et al.   SENSORS

Surface plasmon resonance applications in clinical analysis

(2014) Stefano Mariani et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study

(2014) Simona Santini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix

(2014) Jessica M. Smith et al.   CHEMICAL COMMUNICATIONS

A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins

(2014) Salvatore Cannistraro et al.   International Journal of Nanomedicine

Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery

(2013) Simon G. Patching   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours

(2013) M A Warso et al.   BRITISH JOURNAL OF CANCER

p28, A first in class peptide inhibitor of cop1 binding to p53

(2013) T Yamada et al.   BRITISH JOURNAL OF CANCER

p28, an Anionic Cell-Penetrating Peptide, Increases the Activity of Wild Type and Mutated p53 without Altering Its Conformation

(2013) Tohru Yamada et al.   MOLECULAR PHARMACEUTICS

Activation and control of p53 tetramerization in individual living cells

(2013) G. Gaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway

(2013) C Lv et al.   Cell Death & Disease

Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor

(2013) David C. Fry et al.   ACS Medicinal Chemistry Letters

Small molecules that bind the Mdm2 RING stabilize and activate p53

(2012) P. Roxburgh et al.   CARCINOGENESIS

Mdm2 and MdmX partner to regulate p53

(2012) Xinjiang Wang et al.   FEBS LETTERS

Does azurin bind to the transactivation domain of p53? A Trp phosphorescence study

(2011) Edi Gabellieri et al.   BIOPHYSICAL CHEMISTRY

Interaction of an anticancer peptide fragment of azurin with p53 and its isolated domains studied by atomic force spectroscopy

(2011) Anna Rita Bizzarri et al.   International Journal of Nanomedicine

Azurin modulates the association of Mdm2 with p53: SPR evidence from interaction of the full-length proteins

(2011) Fabio Domenici et al.   JOURNAL OF MOLECULAR RECOGNITION

Modelling the interaction between the p53 DNA-binding domain and the p28 peptide fragment of Azurin

(2011) Simona Santini et al.   JOURNAL OF MOLECULAR RECOGNITION

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements

(2011) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

(2011) V. Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

(2011) L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-family proteins and their regulators: hubs and spokes in tumor suppression

(2010) L Collavin et al.   CELL DEATH AND DIFFERENTIATION

Reactivation of p53 by Novel MDM2 Inhibitors: Implications for Pancreatic Cancer Therapy

(2010) A.S. Azmi et al.   CURRENT CANCER DRUG TARGETS

S100 proteins interact with the N-terminal domain of MDM2

(2010) Jan van Dieck et al.   FEBS LETTERS

Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53

(2010) Elena Kashuba et al.   INTERNATIONAL JOURNAL OF CANCER

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53

(2010) S. Rajagopalan et al.   NUCLEIC ACIDS RESEARCH

p53 Research: The Past Thirty Years and the Next Thirty Years

(2010) D. Lane et al.   Cold Spring Harbor Perspectives in Biology

Studies of interaction of tumor suppressor p53 with apo-MT using surface plasmon resonance

(2009) Ning Xia et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The application of atomic force spectroscopy to the study of biological complexes undergoing a biorecognition process

(2009) Anna Rita Bizzarri et al.   CHEMICAL SOCIETY REVIEWS

A combined atomic force microscopy imaging and docking study to investigate the complex between p53 DNA binding domain and Azurin

(2009) Anna Rita Bizzarri et al.   JOURNAL OF MOLECULAR RECOGNITION

Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy

(2009) Gloria Funari et al.   JOURNAL OF MOLECULAR RECOGNITION

Atomic Force Spectroscopy in Biological Complex Formation: Strategies and Perspectives

(2009) Anna Rita Bizzarri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells

(2009) T. Yamada et al.   MOLECULAR CANCER THERAPEUTICS

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

(2009) M. Pazgier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the MDM2-p53 Interaction for Cancer Therapy

(2008) S. Shangary et al.   CLINICAL CANCER RESEARCH

Probing the interaction between p53 and the bacterial protein azurin by single molecule force spectroscopy

(2008) Monia Taranta et al.   JOURNAL OF MOLECULAR RECOGNITION

Study on the Spatial Architecture of p53, MDM2, and p14ARF Containing Complexes

(2008) Andrej Savchenko et al.   MOLECULAR BIOTECHNOLOGY