Article
Obstetrics & Gynecology
Matthew A. Nestander, Kathryn Berryman, Robert Brady, James Aden, Gayle Haischer-Rollo
Summary: This study aimed to describe the patterns of postmortem investigations for perinatal deaths and compare the degree of investigation between stillbirths and early neonatal deaths. The findings indicate that stillbirths are more likely to undergo autopsies and genetic testing compared to neonatal deaths, highlighting the need for improved investigation methods for neonatal deaths.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Review
Medicine, General & Internal
Sarah Cullen, Eoghan Mooney, Paul Downey
Summary: The amendment to the 1962 Coroner's Act in the Republic of Ireland mandated reporting all cases of stillbirths and neonatal deaths to the local coroner's office. A study following this amendment found that introducing a modified pathway for placental examination improved care for bereaved parents by providing timely information on the cause of stillbirth, thus reducing the need for autopsies in most cases.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Immunology
Salome Maswime, Caroline Pule, Zama Mtshali, Richard Chawana, Mushi Matjila
Summary: Africa has the highest number of pregnant women with HIV, which is associated with adverse perinatal outcomes. The use of antiretroviral therapy has helped reduce transmission and adverse fetal outcomes, but further research is needed to understand the placental mechanisms and fetal immune responses to maternal HIV infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Acoustics
S. C. Shelmerdine, N. J. Sebire, O. J. Arthurs
Summary: The diagnostic accuracy of postmortem ultrasound (PM-US) and postmortem magnetic resonance imaging (PM-MRI) for perinatal autopsy is similar, with high concordance rates for overall diagnosis and individual anatomical regions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Lisa M. Bebell, Joseph Ngonzi, Frederick A. B. Meier, Chrystalle Katte Carreon, Abraham J. Birungi, Vanessa B. Kerry, Raymond Atwine, Drucilla J. Roberts
Summary: This study highlights the importance of placental examination in understanding the causes of perinatal death and improving child health outcomes in resource-limited settings. The authors developed a training program for health workers to collect and examine placentas, resulting in a significant increase in diagnostic capacity. This model can be applied to other research endeavors to enhance diagnostics and management in similar settings.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jialu Qian, Honghe Wu, Shiwen Sun, Man Wang, Xiaoyan Yu
Summary: The study translated the Perinatal Bereavement Care Confidence Scale (PBCCS) into Chinese and confirmed its validity and reliability for use with Chinese midwives and nurses. The results indicated that the Chinese version of PBCCS, known as C-PBCCS, is a psychometrically sound measurement tool that can evaluate the confidence and psychosocial factors affecting Chinese-speaking midwives' and nurses' ability to provide perinatal bereavement care.
Article
Pediatrics
Susan C. Shelmerdine, Neil J. Sebire, Owen J. Arthurs
Summary: A study conducted 2-D and 3-D postmortem ultrasound on 11 fetuses, showing that 3-D did not provide additional information compared to 2-D, therefore routine 3-D postmortem ultrasound is not recommended based on the findings.
PEDIATRIC RADIOLOGY
(2021)
Article
Infectious Diseases
Torsten Hansen, Ulf Titze, Nidhi Su Ann Kulamadayil-Heidenreich, Sabine Glombitza, Johannes Josef Tebbe, Christoph Roecken, Birte Schulz, Michael Weise, Ludwig Wilkens
Summary: An 86-year-old man who was previously asymptomatic received the COVID-19 vaccine and tested positive for SARS-CoV-2 postmortem, showing immunogenicity without sterile immunity. Despite the cause of death being acute bronchopneumonia and tubular failure, characteristic morphological features of COVID-19 were not observed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Rinat Levi, Gali Pariente, Eyal Sheiner, Tamar Wainstock
Summary: This study identified risk factors in first pregnancy for perinatal mortality in the subsequent pregnancy, concluding that complications in first pregnancy ending with live birth are associated with increased risk for perinatal mortality in a subsequent pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Multidisciplinary Sciences
Stefanie Elisabeth Damhuis, Hester Dorien Kamphof, Anita C. J. Ravelli, Sanne Jehanne Gordijn, Wessel J. Ganzevoort
Summary: This study aimed to evaluate the burden of hypoxia-related adverse perinatal outcomes among (near) term births, reflected in an association with birth weight centiles as a proxy for placental function. The study found that the incidence of hypoxia-related outcomes was highest in fetuses with lowest birth weight centiles but can be identified throughout the entire spectrum. Additional diagnostic modalities that indicate placental dysfunction at (near) term gestation are urgently needed.
Article
Health Care Sciences & Services
Gelsomina Mansueto, Mariavictoria De Simone, Paola Ciamarra, Emanuele Capasso, Alessandro Feola, Carlo Pietro Campobasso
Summary: Enterobiasis is a common infectious disease caused by Enterobius vermicularis, usually characterized by anal itching, intestinal or nervous disorders, and rarely fatal outcomes. However, in rare cases, it can lead to death, even in advanced populations, highlighting the importance of awareness and understanding of the potential dangers associated with the disease.
Article
Developmental Biology
Hein Odendaal, Robert Pattinson, Pawel Schubert, Deidre Mason, Lucy Brink, Stefan Gebhardt, Coenraad Groenewald, Colleen Wright
Summary: The clinical cause of death in stillbirths can be modified by adding placental histology and autopsy findings. This study found that combining clinical information with examination of the placenta can provide sufficient information to diagnose the most probable cause of death in a majority of cases.
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Tracey G. Simon, Jonas Soderling, Jonas F. Ludvigsson
Summary: This study investigated the frequency of cirrhosis being discovered at autopsy and not being reported on death certificates. Using register-based data from liver biopsies in Sweden, it was found that out of 6187 patients with postmortem liver biopsies showing cirrhosis, 2523 (41%) did not have a corresponding diagnosis on their death certificates.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Naomi O. Riches, Tsegaselassie Workalemahu, Erin P. Johnson, Robert M. Silver, Sarah Lopez, Jessica Page, Brittney Sartori, Erin Rothwell
Summary: This study conducted interviews with parents who received stillbirth care to understand their needs and preferences in postmortem decision-making. The study suggests the development of a decision aid to provide balanced information and support couple's decision-making.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Pathology
Robert Pell, S. Kim Suvarna, Nigel Cooper, Guy Rutty, Anna Green, Michael Osborn, Peter Johnson, Alison Hayward, Justine Durno, Theodore Estrin-Serlui, Marion Mafham, Ian S. D. Roberts
Summary: This UK multicentre study examined the disruption of healthcare services and excess mortality during the COVID-19 lockdown using coroners' autopsy reports. The study found that while a small number of deaths were directly attributed to COVID-19, delays in accessing medical care and the lockdown were potential factors contributing to death, particularly in cases of suicide and drug/alcohol-related deaths.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Obstetrics & Gynecology
M. A. Beesley, J. R. Davidson, F. Panariello, S. Shibuya, D. Scaglioni, B. C. Jones, K. Maksym, O. Ogunbiyi, N. J. Sebire, D. Cacchiarelli, A. L. David, P. De Coppi, M. F. M. Gerli
Summary: The study indicates that fetal lungs are unlikely to be a route of SARS-CoV2 infection, while the gastrointestinal tract of the fetus may be susceptible due to high expression of both proteins and exposure to potentially infected amniotic fluid. Despite having the required proteins, the fetal kidneys are anatomically protected from virus exposure.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
A. Fagan, O. J. Arthurs, N. J. Sebire, S. C. Shelmerdine
Summary: Cinematic rendering (CR) is a novel post-processing technique that allows for more realistic imaging reconstruction by using a complex light modelling algorithm. It has been shown to provide better realism and expressiveness experience compared to volume rendering (VR) techniques in adult imaging. Additionally, CR improves visualization of musculoskeletal and vascular anatomy and may aid non-radiologists in understanding complex patient anatomy. This review focuses on the potential applications of CR in pediatric musculoskeletal imaging, highlighting its advantages over VR and areas for further research.
CLINICAL RADIOLOGY
(2022)
Article
Infectious Diseases
Emma Vestesson, John Booth, James Hatcher, Orlagh McGarrity, Neil J. Sebire, Adam Steventon, Carlos Suarez Alonso, Stephen Tomlin, Joseph F. Standing
Summary: This study evaluated the impact of the COVID-19 pandemic on antibiotic prescribing in a pediatric hospital in London. The results showed an increase in antibiotic usage during the pandemic, but after adjusting for changes in patient characteristics, there was no evidence of a significant impact on antibiotic prescribing.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G. H. Lindeboom, Colin R. Butler, Natsuhiko Kumasaka, Cecilia Dominguez Conde, Lira Mamanova, Liam Bolt, Laura Richardson, Krzysztof Polanski, Elo Madissoon, Josephine L. Barnes, Jessica Allen-Hyttinen, Eliz Kilich, Brendan C. Jones, Angus de Wilton, Anna Wilbrey-Clark, Waradon Sungnak, J. Patrick Pett, Elena Prigmore, Henry Yung, Puja Mehta, Aarash Saleh, Anita Saigal, Vivian Chu, Jonathan M. Cohen, Clare Cane, Aikaterini Iordanidou, Soichi Shibuya, Ann-Kathrin Reuschl, Ivan T. Herczeg, A. Christine Argento, Richard G. Wunderink, Sean B. Smith, Taylor A. Poor, Catherine A. Gao, Jane E. Dematte, Gary Reynolds, Muzlifah Haniffa, Georgina S. Bowyer, Matthew Coates, Menna R. Clatworthy, Fernando J. Calero-Nieto, Berthold Goettgens, Christopher O'Callaghan, Neil J. Sebire, Clare Jolly, Paolo de Coppi, Claire M. Smith, Alexander Misharin, Sam M. Janes, Sarah A. Teichmann, Marko Z. Nikolic, Kerstin B. Meyer
Summary: Higher innate interferon responses in children may restrict viral replication and disease progression, while the response to SARS-CoV-2 infection differs between children and adults.
Letter
Developmental Biology
T. Yee Khong, Neil J. Sebire, Alexander E. P. Heazell, Wessel Ganzevoort, Frank H. Bloomfield, Elisabeth M. W. Kooi, Mauritia C. Marijnen, Sanne J. Gordijn
Article
Obstetrics & Gynecology
Dimitrios Siassakos, Isabella Bourne, Neil Sebire, Lindsay Kindinger, Sara Melissa Whitten, Clarissa Battaglino
Summary: This study found a correlation between distal villous immaturity (DVI) in the placenta and stillbirth, suggesting a link to glucose dysmetabolism. Some women with DVI, despite not being formally diagnosed with diabetes, had high glucose test results during pregnancy, with a higher risk of stillbirth for their babies.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Pediatrics
Sheena Visram, Deirdre Leyden, Oceiah Annesley, Dauda Bappa, Neil J. Sebire
Summary: This article investigates the attitudes of children and young people towards the application of Artificial Intelligence (AI) in medicine and healthcare. It found that they were more open to certain applications of AI than others, with a focus on human-centeredness, governance, and trust. The article suggests that educational workshops and practical examples can help address concerns and build trust in AI.
PEDIATRIC RESEARCH
(2023)
Article
Chemistry, Analytical
Christian Baker, Miguel Xochicale, Fang-Yu Lin, Sunish Mathews, Francois Joubert, Dzhoshkun I. I. Shakir, Richard Miles, Charles A. A. Mosse, Tianrui Zhao, Weidong Liang, Yada Kunpalin, Brian Dromey, Talisa Mistry, Neil J. J. Sebire, Edward Zhang, Sebastien Ourselin, Paul C. C. Beard, Anna L. L. David, Adrien E. E. Desjardins, Tom Vercauteren, Wenfeng Xia
Summary: Ultrasound needle tracking is an essential tool for minimally-invasive procedures. This study presents a new real-time ultrasound needle tracking system for guidance of fetal interventions, demonstrating its accuracy and clinical compatibility.
Article
Oncology
Laura Privitera, Layla Musleh, Irene Paraboschi, Olumide Ogunlade, Olumide Ogunbiyi, J. Ciaran Hutchinson, Neil Sebire, Paul Beard, Stefano Giuliani
Summary: Neuroblastoma (NB), the most common extracranial tumor in children, can be better treated with the help of imaging techniques such as photoacoustic imaging (PAI) to distinguish viable malignant tissue from necrotic and surrounding healthy tissue. The study found that post-chemotherapy, viable areas of differentiating NBs and ganglioneuroblastomas have higher vascular density, while early necrotic regions have higher vascular density than late necrotic and viable regions. Calcified areas have significantly lower vascular density. The results suggest that PAI can potentially guide surgical resection by identifying different vasculature signatures.
Article
Multidisciplinary Sciences
Bojidar Rangelov, Alexandra Young, Watjana Lilaonitkul, Shahab Aslani, Paul Taylor, Eyjolfur Guomundsson, Qianye Yang, Yipeng Hu, John R. Hurst, David J. Hawkes, Joseph Jacob
Summary: The COVID-19 pandemic has presented a significant challenge to healthcare systems worldwide. This study developed an unsupervised data-driven model called SuStaIn, which can be used to predict short-term infectious diseases like COVID-19 based on commonly recorded clinical measures. The model identified three COVID-19 subtypes and introduced disease severity stages, both of which were predictive of in-hospital mortality or escalation of treatment. This model can be adapted for future outbreaks of COVID-19 or other infectious diseases.
SCIENTIFIC REPORTS
(2023)
Article
Developmental Biology
Nada Mufti, Joanna Chappell, Patrick O'Brien, George Attilakos, Hassna Irzan, Magda Sokolska, Priya Narayanan, Trevor Gaunt, Paul D. Humphries, Premal Patel, Elspeth Whitby, Eric Jauniaux, J. Ciaran Hutchinson, Neil J. Sebire, David Atkinson, Giles Kendall, Sebastien Ourselin, Tom Vercauteren, Anna L. David, Andrew Melbourne
Summary: The study investigates the use of super-resolution reconstruction (SRR) MRI to improve placental assessment and predict adverse maternal outcomes. The results show that SRR imaging and paired imaging can enhance the detection of pathological MRI markers, aiding in surgical planning.
Article
Multidisciplinary Sciences
Taryn D. Treger, John E. G. Lawrence, Nathaniel D. Anderson, Tim H. H. Coorens, Aleksandra Letunovska, Emilie Abby, Henry Lee-Six, Thomas R. W. Oliver, Reem Al-Saadi, Kjell Tullus, Guillaume Morcrette, J. Ciaran Hutchinson, Dyanne Rampling, Neil Sebire, Kathy Pritchard-Jones, Matthew D. Young, Thomas J. Mitchell, Philip H. Jones, Maxine Tran, Sam Behjati, Tanzina Chowdhury
Summary: In this study, we examined somatic changes in reninoma and discovered structural variants involving NOTCH1 and NRARP, resulting in excessive renin and NOTCH1 signaling but normal expression of NRARP. Additionally, our findings were supported by previous studies that also found dysregulated Notch pathway signaling in reninoma.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Rebecca Spencer, Kasia Maksym, Kurt Hecher, Karel Marsal, Francesc Figueras, Gareth Ambler, Harry Whitwell, Nuno Rocha Nene, Neil J. Sebire, Stefan R. Hansson, Anke Diemert, Jana Brodszki, Eduard Gratacos, Yuval Ginsberg, Tal Weissbach, Donald M. Peebles, Ian Zachary, Neil Marlow, Angela Huertas-Ceballos, Anna L. David
Summary: This study investigates the use of maternal serum protein and ultrasound measurements to predict outcomes in pregnancies affected by severe, early-onset fetal growth restriction (FGR). The results demonstrate that ultrasound measurements and maternal serum PlGF concentration can predict important pregnancy outcomes for patients and clinicians.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Correction
Multidisciplinary Sciences
Gerda Kildisiute, Waleed M. Kholosy, Matthew D. Young, Kenny Roberts, Rasa Elmentaite, Sander R. van Hooff, Clarissa N. Pacyna, Eleonora Khabirova, Alice Piapi, Christine Thevanesan, Eva Bugallo-Blanco, Christina Burke, Lira Mamanova, Lira Mamanova, Kaylee M. Keller, Karin P. S. Langenberg-Ververgaert, Philip Lijnzaad, Thanasis Margaritis, Frank C. P. Holstege, Michelle L. Tas, Marc H. W. A. Wijnen, Max M. van Noesel, Ignacio Del Valle, Giuseppe Barone, Reinier van der Linden, Catriona Duncan, John Anderson, John C. Achermann, Muzlifah Haniffa, Sarah A. Teichmann, Dyanne Rampling, Neil J. Sebire, Xiaoling He, Ronald R. de Krijger, Roger A. Barker, Kerstin B. Meyer, Omer Bayraktar, Karin Straathof, Jan J. Molenaar, Sam Behjati
Article
Pediatrics
Milagros Ruiz Nishiki, Melissa Cabecinha, Rachel Knowles, Catherine Peters, Helen Aitkenhead, Adeboye Ifederu, Nadia Schoenmakers, Neil J. Sebire, Erin Walker, Pia Hardelid
Summary: This study aims to determine risk factors for congenital hypothyroidism with gland in situ (CH-GIS) and describe long-term health and education outcomes for affected children using linked administrative health, education and clinical data. Logistic/multinomial regression models will be used to identify risk factors for CH-GIS, while generalised linear models or Cox proportional hazards regression models will assess the association between type of CH and school performance or health outcomes. The study has received ethical approval and its findings will be disseminated through peer-reviewed journals and academic conferences.
BMJ PAEDIATRICS OPEN
(2022)
