Review
Biochemistry & Molecular Biology
Marcelo Villagran, Jorge Ferreira, Miquel Martorell, Lorena Mardones
Summary: Vitamin C plays a significant role in cancer prevention and treatment, with studies showing its potential benefits in preventing pulmonary and breast cancer, as well as its synergistic effects with pancreatic cancer drugs. However, a Mendelian randomized study did not find an association between vitamin C and cancer prevention. Ongoing research is needed to further explore the therapeutic role of vitamin C in cancer through new phase II and III clinical trials.
Review
Oncology
Franziska Bottger, Andrea Valles-Marti, Loraine Cahn, Connie R. Jimenez
Summary: Vitamin C has potential as a potent anti-cancer agent when administered intravenously and in high doses. It demonstrates multi-targeting effects as a cancer-specific, pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator, and immune modulator. Despite lacking strong clinical data and phase III studies, there is a need for more awareness and utilization of this promising, non-toxic cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Nutrition & Dietetics
Olga Brzezinska, Filip Styrzynski, Joanna Makowska, Konrad Walczak
Summary: Gout is a common disease affected by environmental factors like diet. Vitamin C may play a role in prevention and treatment of gout, but further research is needed to fully understand its benefits.
Article
Cell Biology
Luciano Ferrada, Maria Jose Barahona, Matias Vera, Brent R. Stockwell, Francisco Nualart
Summary: The combination therapy of imidazole ketone erastin (IKE) and oxidized form of vitamin C (DHAA) can restore sensitivity to ferroptosis in previously resistant tumor cells and induce lipid droplet peroxidation, leading to ferroptosis.
CELL DEATH & DISEASE
(2023)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Critical Care Medicine
Adham Mohamed, Mohamed Abdelaty, Mohamed O. Saad, Ahmed Shible, Hassan Mitwally, Abdel-Rauof Akkari, Abdurrahmaan Elbuzidi, Awadh Bintaher, Ahmed Hashim, Magid Abdelrahim, Mohammad Afzal, Rasha El-Enany, Maha El-Hamid, Dana Bakdach, Edin Karic, Ahmed Shehatta, Abdul-Salam Ibrahim, Marcus Lance, Ali Ait Hssain, Ibrahim Hassan
Summary: The purpose of the study is to evaluate the effect of combined hydrocortisone, vitamin C, and thiamine (triple therapy) on the mortality of patients with septic shock. The results showed that triple therapy did not improve in-hospital mortality at 60 days in critically ill patients with septic shock or reduce the vasopressor duration or SOFA score at 72 h.
Review
Biochemistry & Molecular Biology
Louise Idalgo Vasques, Cristina Wohlke Vendruscolo, Gislaine Ricci Leonardi
Summary: The topical application of vitamin C and its derivatives in skincare is essential, but there is still a lack of scientific data regarding their efficacy, especially in vivo. Studies on the stability, safety, adverse reactions, and efficacy with standardized parameters and a relevant number of subjects are necessary for better understanding their effects.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Nayef Chahin, Miheret S. Yitayew, Alicia Richards, Brielle Forsthoffer, Jie Xu, Karen D. Hendricks-Munoz
Summary: Little is known about the nutritional needs of premature infants <37 weeks gestation. This study investigated the relationship between infant characteristics, maternal health, and plasma ascorbic acid (AscA) levels in premature infants during postnatal development. The results suggest that prenatal and postnatal factors influence the initial AscA levels, potentially impacting organ health and disease risk. Dietary targets may need to be adjusted for this population.
Review
Immunology
Leonce Kouakanou, Christian Peters, Christine E. Brown, Dieter Kabelitz, Leo D. Wang
Summary: Vitamin C at high doses has direct anti-cancer activity through oxidant and epigenetic mechanisms, killing tumor cells. Recent studies also suggest that pharmacologic-dose Vitamin C can control tumor growth by modulating the immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gwendolyn van Gorkom, Birgit Gijsbers, Erik-Jan Ververs, Ahmed El Molla, Cindy Sarodnik, Celine Riess, Will Wodzig, Gerard Bos, Catharina Van Elssen
Summary: Given the growing interest in ascorbic acid (AA), a method to measure AA levels in the human body is needed. This study presents a method using hydrophilic interaction liquid chromatography (HILIC) to measure AA in peripheral blood mononuclear cells (PBMCs). The method is also applicable to plasma and other leukocyte subsets. The study found that the method is reliable and accurate in measuring AA in PBMCs and plasma.
Review
Biochemistry & Molecular Biology
Mariam Markouli, Dimitrios Strepkos, Christina Piperi
Summary: Hematologic malignancies are closely related to the abnormal regulation of histone modifications. Deregulation of epigenetic enzymes can lead to chromatin remodeling and altered gene expression. Recent advances in epigenetics have identified new therapeutic targets and a variety of drugs are being investigated in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
David C. Noriega-Gonzalez, Franchek Drobnic, Alberto Caballero-Garcia, Enrique Roche, Daniel Perez-Valdecantos, Alfredo Cordova
Summary: Tendinopathies account for 30-50% of all sports injuries, with collagen I being the main component of tendons. Vitamin C supplementation potentially aids in tendinopathy recovery by increasing collagen synthesis, while vitamin C deficiency hinders tendon repair by reducing procollagen synthesis and hydroxylation of specific residues.
Review
Biochemistry & Molecular Biology
Ahmad Machmouchi, Laudy Chehade, Sally Temraz, Ali Shamseddine
Summary: Targeted monoclonal antibody therapy against EGFR is a leading treatment for mCRC. However, resistance due to KRAS and BRAF mutations has emerged. Cells with these mutations overexpress GLUT1 and SVCT2, leading to intracellular vitamin C transport and cell death. High dose vitamin C shows promise in overcoming EGFR resistance in mCRC with wild KRAS mutation and in patients with KRAS and BRAF mutations, but more clinical trials are needed.
Article
Nutrition & Dietetics
Xiaoqin Luo, Wanyu Zhang, Zhangya He, Hexiang Yang, Jiayi Gao, Pei Wu, Zheng Feei Ma
Summary: This study found that increasing dietary vitamin C intake can improve glucose metabolism and liver function, possibly by reducing iron accumulation indicated by ferritin.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Burton Dunlap, G. Taylor Patterson, Sandeep Kumar, Sagar Vyavahare, Samarth Mishra, Carlos Isales, Sadanand Fulzele
Summary: 14% of US adults have been diagnosed with or show symptoms of osteoarthritis, with incidence gradually increasing over the past 30 years. The aging population and obesity prevalence exacerbate the situation. Research on antioxidant supplementation, particularly vitamin C, for treating osteoarthritis is controversial and further randomized controlled trials in humans are urgently needed.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Oncology
Staffan Holmberg-Thyden, Inge Hogh Dufva, Anne Ortved Gang, Marie Fredslund Breinholt, Lone Schejbel, Mette Klarskov Andersen, Mohammad Kadivar, Inge Marie Svane, Kirsten Gronbaek, Sine Reker Hadrup, Daniel El Fassi
Summary: This study aimed to combine a multi-peptide cancer vaccine with epigenetic therapy in high-risk MDS patients, but no specific immune responses were detected and all patients progressed to AML shortly after initiating the combination therapy. Despite the negative results, the study highlights the challenges of inducing immune reactivity in high-risk MDS patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Mette Dahl, Simon Husby, Christian W. Eskelund, Soren Besenbacher, Soren Fjelstrup, Christophe Come, Sara Ek, Arne Kolstad, Riikka Raty, Mats Jerkeman, Christian H. Geisler, Jorgen Kjems, Lasse S. Kristensen, Kirsten Gronbaek
Summary: Circular RNAs (circRNAs) show promise as prognostic biomarkers in mantle cell lymphoma (MCL); the circSCORE signature improves the identification of high-risk disease in younger patients receiving cytarabine-containing chemoimmunotherapy and autologous stem cell transplant.
Article
Biology
Morteza Chalabi Hajkarim, Ella Karjalainen, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L. Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Gronbaek, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won
Summary: In this article, the authors introduce a toolkit called compaRe for large-scale multiparameter data analysis. The toolkit integrates quality control, data bias correction, and data visualization methods, and provides faster and more reliable analysis results through a mass-aware gridding algorithm-based similarity analysis. The results show that compaRe can reveal interpatient heterogeneity and recognizable phenotypic profiles, as well as identify multiple types of phenotypic response patterns in drug response data.
Letter
Oncology
Bengt Rasmussen, Gudrun Gohring, Elsa Bernard, Lars Nilsson, Magnus Tobiasson, Martin Jadersten, Hege Garelius, Ingunn Dybedal, Kirsten Gronbaek, Elisabeth Ejerblad, Fryderyk Lorenz, Max Flogegard, Claus Werenberg Marcher, Annette oster Fernstrom, Lucia Cavelier, Elli Papaemmanuil, Freja Ebeling, Astrid Olsnes Kittang, Jan Maxwell Norgaard, Leonie Saft, Lars Mollgard, Eva Hellstrom-Lindberg
Article
Hematology
Dicte Traeden, Morten Tulstrup, Jack Bernard Cowland, Lene Dissing Sjo, Martin Bogsted, Kirsten Gronbaek, Mette Klarskov Andersen, Jakob Werner Hansen
Summary: This study demonstrates that next-generation sequencing (NGS) combined with clinical data can predict the presence of abnormal bone marrow morphology in patients with unexplained cytopenia, providing a potential alternative to bone marrow biopsy.
Review
Oncology
Djordje Marina, Ase Krogh Rasmussen, Kristian Buch-Larsen, Linn Gillberg, Michael Andersson, Peter Schwarz
Summary: Tamoxifen treatment in breast cancer patients may lead to mild and transient thyroid dysfunction, while letrozole treatment does not appear to have significant effects. Current literature has not focused on subclinical hypothyroidism as a potential cause of weight gain in breast cancer patients.
Article
Oncology
Agnete Marie Granau, Pilar Aaroe Andersen, Theresa Jakobsen, Konstantina Taouxi, Nawar Dalila, Johanne Bay Mogensen, Lasse Sommer Kristensen, Kirsten Gronbaek, Konstantinos Dimopoulos
Summary: Targeting BCL-2 through venetoclax is an effective therapy for hematological cancers, but resistance is a challenge that needs to be overcome. Through genetic, epigenetic and transcriptomic analyses, we found that venetoclax-resistant cells acquired a TP53 mutation and showed an upregulation of the PI3K/Akt pathway. Inhibition of Akt and ERK with TIC-10 induced apoptosis in venetoclax-resistant cells. TIC-10 might be a potential treatment option for venetoclax-resistant patients.
Article
Biochemistry & Molecular Biology
Tina Ronn, Alexander Perfilyev, Josefine Jonsson, Karl-Fredrik Eriksson, Sine W. Jorgensen, Charlotte Brons, Linn Gillberg, Allan Vaag, Elisabet Stener-Victorin, Charlotte Ling
Summary: This study found an association between DNA methylation levels in adipose tissue and circulating lipid levels, and identified novel epigenetic changes associated with lipid levels. These findings provide insights into the relationship between dysregulation of circulating lipids and epigenetic mechanisms in adipose tissue, and have important implications for the study of metabolic syndrome.
HUMAN MOLECULAR GENETICS
(2023)
Article
Oncology
Katja Kaastrup, Linn Gillberg, Stine U. Mikkelsen, Andreas D. orskov, Claudia Schollkopf, Bo K. Mortensen, Bo Porse, Jakob W. Hansen, Kirsten Gronbaek
Summary: Idiopathic non-clonal cytopenia (ICUS) and clonal cytopenia (CCUS) are common in the elderly population. Aberrant DNA methylation, including hypermethylation of the LEP promoter, is associated with these disorders and myeloid neoplasms such as myelodysplastic syndrome (MDS). Hypermethylation of the LEP promoter is an early event in myeloid neoplasms and is associated with a worse prognosis.
CLINICAL EPIGENETICS
(2023)
Editorial Material
Physiology
Arthur Ingersen, Casper Soendenbroe, Haboon Ismail Ahmed, Jacob Borch, Kristine Frosig Moseholm, Mette Hyldig Dal, Olsi Kusta, Sofie Olsgaard Bergien, Linn Gillberg
Article
Hematology
Jesper Therkelsen, Dicte Wilhjelm Traeden, Ida Schjodt, Mette Klarskov Andersen, Lene Dissing Sjo, Jakob Werner Hansen, Kirsten Gronbaek, Konstantinos Dimopoulos
Summary: A novel score, ProGraME, combining flow cytometry (FC), morphology, and cytogenetic/molecular assessment, is developed for the diagnosis of low-risk myelodysplasia without minimal requirements of flow analysis other than accurate population gating.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Genetics & Heredity
Marwa Almosailleakh, Sofia Bentivegna, Samuele Narcisi, Sebasitien J. Benquet, Linn Gillberg, Carmen P. Montano-Almendras, Simonas Savickas, Erwin M. Schoof, Amelie Wegener, Herve Luche, Henrik E. Jensen, Christophe Come, Kirsten Gronbaek
Summary: KANK1 is a proposed tumour suppressor gene that is reduced or absent in several types of tumour tissue. A new germline loss of heterozygosity mutation in the KANK1 gene was found in a patient diagnosed with myelodysplastic neoplasm. KANK1 knockout mice showed altered colony forming and proliferative potential of bone marrow cells, as well as a decrease in hematopoietic stem and progenitor cells.
Article
Endocrinology & Metabolism
Chih-Hsiang Yang, Luca Fagnocchi, Stefanos Apostle, Vanessa Wegert, Salvador Casani-Galdon, Kathrin Landgraf, Ilaria Panzeri, Erez Dror, Steffen Heyne, Till Woerpel, Darrell P. Chandler, Di Lu, Tao Yang, Elizabeth Gibbons, Rita Guerreiro, Jose Bras, Martin Thomasen, Louise G. Grunnet, Allan A. Vaag, Linn Gillberg, Elin Grundberg, Ana Conesa, Antje Korner, J. Andrew Pospisilik
Summary: This study identifies neuronatin (NNAT) as a factor that buffers against unexplained phenotypic variation (UPV), independent of genetics or environment. NNAT-dependent variations can stratify human cohorts into four metabolic subtypes, including two distinct types of obesity.
Article
Oncology
Lavanya Lokhande, Venera Kuci Emruli, Christian Winther Eskelund, Arne Kolstad, Martin Hutchings, Riikka Raty, Carsten Utoft Niemann, Kirsten Gronbaek, Mats Jerkeman, Sara Ek
Summary: Analyzing changes in the serum proteome of relapsed MCL patients before and after treatment provides insights into the biological mechanisms underlying treatment response in specific patient sub-groups.