期刊
SEMINARS IN CANCER BIOLOGY
卷 51, 期 -, 页码 59-67出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2017.11.001
关键词
Vitamin C; Epigenetics; Cancer treatment; Hematological malignancies; Ascorbic acid
类别
资金
- Danish Cancer Society
- Rigshospitalets Research Foundation
- Lundbeck Foundation
- Novo Nordisk Foundation
- National Institute of Health [R35CA209858]
- Van Andel Research Institute through the Van Andel Research Institute Stand Up To Cancer Epigenetics Dream Team
- NATIONAL CANCER INSTITUTE [R35CA209859] Funding Source: NIH RePORTER
- Lundbeck Foundation [R180-2014-3675] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0003435] Funding Source: researchfish
- The Danish Cancer Society [R124-A7695] Funding Source: researchfish
- Novo Nordisk Foundation Section for Basic Stem Cell Biology [Gr�nb�k group NNF] Funding Source: researchfish
Over the past few years it has become clear that vitamin C, as a provider of reduced iron, is an essential factor for the function of epigenetic regulators that initiate the demethylation of DNA and histones. Vitamin C deficiency is rare in the general population, but is frequently observed in patients with cancer. Genes encoding epigenetic regulators are often mutated in cancer, underscoring their central roles in carcinogenesis. In hematological cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), drugs that reverse epigenetic aberrations are now the standard of care. Recent in vitro studies suggest that vitamin C at physiological concentrations, combined with hypomethylating agents may act synergistically to cause DNA demethylation through active and passive mechanisms, respectively. Additionally, several recent studies have renewed interest in the use of pharmacological doses of vitamin C injected intravenously to selectively kill tumor cells. This review will focus on the potential of vitamin C to optimize the outcome of epigenetic therapy in cancer patients and alternatively to act as a therapeutic at high doses.
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