Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension

Bone Morphogenetic Protein Receptor Type II Deficiency and Increased Inflammatory Cytokine Production. A Gateway to Pulmonary Arterial Hypertension

(2015) Elaine Soon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension

(2015) Sherry E. Adesina et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

(2015) Kurt R. Stenmark et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial dynamics in pulmonary arterial hypertension

(2015) John Ryan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

(2014) Scott A. Barman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

The Metabolic Theory of Pulmonary Arterial Hypertension

(2014) Roxane Paulin et al.   CIRCULATION RESEARCH

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Complex I Deficiency Due to Selective Loss of Ndufs4 in the Mouse Heart Results in Severe Hypertrophic Cardiomyopathy

(2014) Edward T. Chouchani et al.   PLoS One

Mitochondria: from cell death executioners to regulators of cell differentiation

(2014) Atsuko Kasahara et al.   TRENDS IN CELL BIOLOGY

MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts

(2013) Daren Wang et al.   CIRCULATION RESEARCH

Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect

(2013) Katherine A. Cottrill et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Suppression of Mitochondrial Complex I Influences Cell Metastatic Properties

(2013) Xuelian He et al.   PLoS One

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

(2013) Luke Barron et al.   PLoS One

Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension

(2012) Adil Anwar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Adventitia: Essential Regulator of Vascular Wall Structure and Function

(2012) Kurt R. Stenmark et al.   Annual Review of Physiology

Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling

(2012) Evgeniy Panzhinskiy et al.   CARDIOVASCULAR RESEARCH

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases

(2012) S. Koene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Targeting the Adventitial Microenvironment in Pulmonary Hypertension: A Potential Approach to Therapy that Considers Epigenetic Change

(2012) Kurt R. Stenmark et al.   Pulmonary Circulation

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Activation of the cAMP cascade in human fibroblast cultures rescues the activity of oxidatively damaged complex I

(2011) Domenico De Rasmo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension

(2011) M. Li et al.   JOURNAL OF IMMUNOLOGY

Pharmacological targeting of mitochondrial complex I deficiency: The cellular level and beyond

(2011) Peggy Roestenberg et al.   MITOCHONDRION

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

(2010) Iwona Fijalkowska et al.   AMERICAN JOURNAL OF PATHOLOGY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall

(2009) Maria G. Frid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

(2009) Paul M. Hassoun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKC  in the pulmonary artery adventitia

(2008) M. Das et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Complex I superoxide production is attenuated by uncoupling

(2008) Andrea Dlasková et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Gene Transfer of Extracellular Superoxide Dismutase Ameliorates Pulmonary Hypertension in Rats

(2007) Fumihiko Kamezaki et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fibroblasts as novel therapeutic targets in chronic inflammation

(2007) S J Flavell et al.   BRITISH JOURNAL OF PHARMACOLOGY