Complete attenuation of genetically engineeredPlasmodium falciparumsporozoites in human subjects

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

(2016) Kristian E. Swearingen et al.   PLoS Pathogens

Novel approaches to whole sporozoite vaccination against malaria

(2015) Else M. Bijker et al.   VACCINE

Susceptibility to Plasmodium yoelii Preerythrocytic Infection in BALB/c Substrains Is Determined at the Point of Hepatocyte Invasion

(2014) Alexis Kaushansky et al.   INFECTION AND IMMUNITY

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals

(2014) Susanne H. Hodgson et al.   JOURNAL OF INFECTIOUS DISEASES

A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

(2014) Sebastian A Mikolajczak et al.   MOLECULAR THERAPY

Soluble HIV-1 Envelope Immunogens Derived from an Elite Neutralizer Elicit Cross-Reactive V1V2 Antibodies and Low Potency Neutralizing Antibodies

(2014) Sara Carbonetti et al.   PLoS One

Safety and Comparability of Controlled Human Plasmodium falciparum Infection by Mosquito Bite in Malaria-Naïve Subjects at a New Facility for Sporozoite Challenge

(2014) Angela K. Talley et al.   PLoS One

Immunization with genetically attenuated P. falciparum parasites induces long-lived antibodies that efficiently block hepatocyte invasion by sporozoites

(2014) Olivia C. Finney et al.   VACCINE

Model forIn VivoAssessment of Humoral Protection against Malaria Sporozoite Challenge by Passive Transfer of Monoclonal Antibodies and Immune Serum

(2013) Brandon K. Sack et al.   INFECTION AND IMMUNITY

Immune mechanisms in malaria: new insights in vaccine development

(2013) Eleanor M Riley et al.   NATURE MEDICINE

Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure

(2013) Ally Olotu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

(2013) R. A. Seder et al.   SCIENCE

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

(2013) Michele Spring et al.   VACCINE

Pre-erythrocytic antibody profiles induced by controlled human malaria infections in healthy volunteers under chloroquine prophylaxis

(2013) Philip L. Felgner et al.   Scientific Reports

Genetic engineering of attenuated malaria parasites for vaccination

(2012) Shahid M Khan et al.   CURRENT OPINION IN BIOTECHNOLOGY

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

(2012) Ashley M. Vaughan et al.   JOURNAL OF CLINICAL INVESTIGATION

Laser Cutting Eliminates Nucleic Acid Cross-Contamination in Dried-Blood-Spot Processing

(2012) S. C. Murphy et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A transgenic Plasmodium falciparum NF54 strain that expresses GFP–luciferase throughout the parasite life cycle

(2012) Ashley M. Vaughan et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Development of a quantitative flow cytometry-based assay to assess infection by Plasmodium falciparum sporozoites

(2012) Alexis Kaushansky et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines

(2012) Matthew B. Laurens et al.   VACCINE

Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

(2011) Noah S. Butler et al.   Cell Host & Microbe

The RTS,S vaccine candidate for malaria

(2011) Jason A Regules et al.   Expert Review of Vaccines

Protective Immunity Induced with the RTS,S/AS Vaccine Is Associated with IL-2 and TNF-α Producing Effector and Central Memory CD4+ T Cells

(2011) Joanne M. Lumsden et al.   PLoS One

Development of a metabolically active, non-replicating sporozoite vaccine to preventPlasmodium falciparummalaria

(2010) Stephen L. Hoffman et al.   Human vaccines & immunotherapeutics

Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

(2010) Nathan W. Schmidt et al.   PLoS Pathogens

Advances and challenges in malaria vaccine development

(2009) Ruobing Wang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Protection against a Malaria Challenge by Sporozoite Inoculation

(2009) Meta Roestenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

(2009) K. M. VanBuskirk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving the expression of recombinant soluble HIV Envelope glycoproteins using pseudo-stable transient transfection

(2009) George Sellhorn et al.   VACCINE

Distinct Malaria Parasite Sporozoites Reveal Transcriptional Changes That Cause Differential Tissue Infection Competence in the Mosquito Vector and Mammalian Host

(2008) S. A. Mikolajczak et al.   MOLECULAR AND CELLULAR BIOLOGY