TLR-Induced SMPD3 Defects Enhance Inflammatory Response of B Cell and Macrophage in the Pathogenesis of SLE

TLR9-induced miR-155 and Ets-1 decrease expression of CD1d on B cells in SLE

(2015) Fei Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation

(2015) Kristin Baudiß et al.   EUROPEAN RESPIRATORY JOURNAL

miR-155 Deficiency Ameliorates Autoimmune Inflammation of Systemic Lupus Erythematosus by TargetingS1pr1inFaslpr/lprMice

(2015) Qian Xin et al.   JOURNAL OF IMMUNOLOGY

Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides

(2015) Lisa Kain et al.   MOLECULAR IMMUNOLOGY

Cognate interaction with iNKT cells expands IL-10–producing B regulatory cells

(2015) Emilie E. Vomhof-DeKrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRR-signaling pathways: Learning from microbial tactics

(2015) Gernot Sellge et al.   SEMINARS IN IMMUNOLOGY

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus

(2015) Ji Hyun Sim et al.   ARTHRITIS RESEARCH & THERAPY

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

(2015) Leonhard X. Heinz et al.   Cell Reports

Type I Interferon-Mediated Skewing of the Serotonin Synthesis Is Associated with Severe Disease in Systemic Lupus Erythematosus

(2015) Christian Lood et al.   PLoS One

The efficacy of novel B cell biologics as the future of SLE treatment: A review

(2014) Ameer Kamal et al.   AUTOIMMUNITY REVIEWS

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus

(2014) H Fan et al.   Cell Death & Disease

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages

(2013) Junfei Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases

(2013) Jing Li et al.   PHARMACOLOGY & THERAPEUTICS

Sphingolipid Signaling in Metabolic Disorders

(2012) Timothy Hla et al.   Cell Metabolism

Lipid-Antigen Presentation by CD1d+ B Cells Is Essential for the Maintenance of Invariant Natural Killer T Cells

(2012) Anneleen Bosma et al.   IMMUNITY

Metabolic Disturbances Associated with Systemic Lupus Erythematosus

(2012) Tianfu Wu et al.   PLoS One

Acid sphingomyelinase in macrophage biology

(2011) Jean-Philip Truman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exogenous Ceramide-1-phosphate Reduces Lipopolysaccharide (LPS)-mediated Cytokine Expression

(2011) Jody L. Hankins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brief Treatment with iNKT Cell Ligand α-Galactosylceramide Confers a Long-term Protection Against Lupus

(2011) Jun-Qi Yang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional repression of ceramide kinase in LPS-challenged macrophages

(2010) Philipp Rovina et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ceramide and Ceramide 1-Phosphate Are Negative Regulators of TNF-  Production Induced by Lipopolysaccharide

(2010) S. Jozefowski et al.   JOURNAL OF IMMUNOLOGY

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

Alpha versus beta: are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?

(2009) Y. Ilan   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages

(2008) Jeniter E. Hughes et al.   CIRCULATION RESEARCH

A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-α and induces interleukin-10 production in activated macrophages

(2008) Meir Goldsmith et al.   IMMUNOLOGY

Dexamethasone cyclophosphamide pulse therapy in systemic lupus erythematosus: A case report

(2008) Ramji Gupta et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE