Identification of an optimized 2′- O -methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8

TLR7 Structure: Cut in Z-Loop

(2016) Kazuhiko Maeda et al.   IMMUNITY

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

(2016) Zhikuan Zhang et al.   IMMUNITY

Toll-like receptors: potential targets for lupus treatment

(2015) Yan-wei Wu et al.   ACTA PHARMACOLOGICA SINICA

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

(2015) A. Kru ger et al.   EMBO REPORTS

Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses

(2015) Tatjana Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition ofStreptococcus pyogenes

(2015) Tatjana Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

TLR8 SensesStaphylococcus aureusRNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

(2015) Bjarte Bergstrøm et al.   JOURNAL OF IMMUNOLOGY

2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells

(2015) Katharina Rimbach et al.   Journal of Innate Immunity

Synergistic activation of Toll-like receptor 8 by two RNA degradation products

(2015) Matthias Geyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synergistic activation of Toll-like receptor 8 by two RNA degradation products

(2015) Matthias Geyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Single Naturally Occurring 2’-O-Methylation Converts a TLR7- and TLR8-Activating RNA into a TLR8-Specific Ligand

(2015) Stephanie Jung et al.   PLoS One

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Modifications in Small Interfering RNA That Separate Immunostimulation from RNA Interference

(2014) F. Eberle et al.   JOURNAL OF IMMUNOLOGY

A modified dinucleotide motif specifies tRNA recognition by TLR7

(2014) Steffen Kaiser et al.   RNA

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

(2013) Fu-Gang Zhu et al.   AUTOIMMUNITY

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes

(2013) Jorge L. Cervantes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Suppression of Molecular Inflammatory Pathways by Toll-Like Receptor 7, 8, and 9 Antagonists in a Model of IL-23-Induced Skin Inflammation

(2013) Mayte Suárez-Fariñas et al.   PLoS One

The 2′-O-methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition

(2012) Stefanie Jöckel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

(2012) Stefanie Gehrig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

RNA nucleotide methylation

(2011) Yuri Motorin et al.   Wiley Interdisciplinary Reviews-RNA

Macrophages recognize streptococci through bacterial single-stranded RNA

(2010) Sachin D Deshmukh et al.   EMBO REPORTS

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

Bacterial RNA is recognized by different sets of immunoreceptors

(2009) Florian Eberle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

(2009) Svetlana Hamm et al.   IMMUNOBIOLOGY

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE