Article
Oncology
Seungbum Wi, Bo-Guen Kim, Sun Hye Shin, Byung Woo Jhun, Hongseok Yoo, Byeong-Ho Jeong, Kyungjong Lee, Hojoong Kim, O. Jung Kwon, Joungho Han, Jhingook Kim, Sang-Won Um
Summary: This study assessed the clinical utility of EBUS-TBNA for station 10/11/12 lymph nodes in patients with primary lung cancer. The overall diagnostic sensitivity, specificity, and accuracy of EBUS-TBNA were high, with better performance for LNs >=10 mm in size. There was no significant difference in diagnostic performance based on nodal station or left-right location.
Article
Multidisciplinary Sciences
Maja Guberina, Ken Herrmann, Christoph Poettgen, Nika Guberina, Hubertus Hautzel, Thomas Gauler, Till Ploenes, Lale Umutlu, Axel Wetter, Dirk Theegarten, Clemens Aigner, Wilfried E. E. Eberhardt, Martin Metzenmacher, Marcel Wiesweg, Martin Schuler, Ruediger Karpf-Wissel, Alina Santiago Garcia, Kaid Darwiche, Martin Stuschke
Summary: This study aimed to predict lymph node involvement in non-small cell lung cancer patients using machine learning models, and the results showed that PET/CT-based machine learning classifiers can achieve high sensitivity to detect lymph node involvement at a low misclassification rate.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Olivia Lucey, Jessica Potter, William Ricketts, Lianne Castle, Mark Melzer
Summary: This study characterises and describes the diagnostic utility of Endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) in intrathoracic tuberculosis. The results show that EBUS-TBNA has high sensitivity and specificity for tuberculosis, and it is recommended to perform mycobacterial culture in all cases in high tuberculosis incidence areas.
JOURNAL OF INFECTION
(2022)
Article
Oncology
M. P. J. Visser, I van Grimbergen, J. Holters, W. B. Barendregt, L. C. Vermeer, W. Vreuls, J. Janssen
Summary: This retrospective study evaluated the performance of EBUS and mediastinoscopy in mediastinal lymph node staging in NSCLC patients. The results showed a higher percentage of unforeseen N2 cases after negative EBUS, and a difference in survival between surgically confirmed N2 metastases and EBUS/mediastinoscopy-proven N2 metastases. Despite optimization of mediastinal staging procedures, it remains challenging to identify all N2 metastases in NSCLC workup.
Review
Medicine, General & Internal
Valentina Scano, Alessandro Giuseppe Fois, Andrea Manca, Francesca Balata, Angelo Zinellu, Carla Chessa, Pietro Pirina, Panos Paliogiannis
Summary: Mediastinal lymphadenopathy refers to the enlargement of mediastinal lymph nodes due to malignant or benign causes, and can be diagnosed using EBUS. EBUS is a reliable alternative to surgery for non-neoplastic mediastinal lymphadenopathy, but more evidence is needed for granulomatous diseases.
Article
Medicine, General & Internal
Jurgen Hetzel, Laetitia A. A. Mauti, Jonas Winkler, Sabine Cardoso Almeida, Philip Jermann, Miklos Pless, Lukas Bubendorf, Peter Karl Bode, Maik Haentschel
Summary: Personalized treatment of metastatic non-squamous NSCLC requires comprehensive molecular characterization of the tumor, including detection of driver mutations and PD-L1 expression. Different sampling techniques may be necessary to obtain sufficient tumor material. This case report highlights the importance of biopsy technique for precise tumor characterization. Only EBUS-TBLNC provided complete characterization, demonstrating PD-L1 expression without actionable genetic alterations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alice Stanton, Kevin Conroy, Graham Miller
Summary: A 72-year-old female patient underwent endobronchial ultrasound and transbronchial needle aspirate sampling of mediastinal lymph nodes to investigate a middle lobe abnormality following an urgent referral. CT imaging completed the following day demonstrated a pneumomediastinum. At clinical review, the patient remained clinically stable and no intervention was required.
Article
Oncology
Roberto Martin-Deleon, Cristina Teixido, Carmen Ma Lucena, Daniel Martinez, Ainhoa Fontana, Roxana Reyes, Mireia Garcia, Nuria Vinolas, Ivan Vollmer, Marcelo Sanchez, Pedro Jares, Francisco Manuel Perez, Naiara Vega, Elba Marin, Ramon Ma Marrades, Carlos Agusti, Noemi Reguart
Summary: The study evaluated the reliability of EBUS-TBNA samples for comprehensive molecular and immunohistochemical testing in NSCLC, showing that they are a feasible alternative for genotyping and can improve patient selection for personalized therapies with high concordance when compared with traditional biopsy samples.
Review
Cardiac & Cardiovascular Systems
Abhinav Agrawal, Uzair Ghori, Udit Chaddha, Septimiu Murgu
Summary: The combination of EBUS-IFB and EBUS-TBNA improves the overall diagnostic yield of sampling intrathoracic adenopathy when compared with EBUS-TBNA alone, although it has a higher complication rate.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Paul Zarogoulidis, Wolfgang Hohenforst-Schmidt, Haidong Huang, Jun Zhou, Qin Wang, Xiangqi Wang, Ying Xia, Yinfeng Ding, Chong Bai, Christoforos Kosmidis, Konstantinos Sapalidis, Chrysanthi Sardeli, Kosmas Tsakiridis, Bojan Zaric, Tomi Kovacevic, Vladimir Stojsic, Tatjana Sarcev, Daliborka Bursac, Biljana Kukic, Sofia Baka, Evagelia Athanasiou, Dimitrios Hatzibougias, Electra Michalopoulou-Manoloutsiou, Savvas Petanidis, Dimitris Drougas, Konstantinos Drevelegas, Dimitris Paliouras, Nikolaos Barbetakis, Anastasios Vagionas, Lutz Freitag, Aimilios Lallas, Ioannis Boukovinas, Dimitris Petridis, Aris Ioannidis, Dimitris Matthaios, Konstantinos Romanidis, Chrisanthi Karapantzou
Summary: Immunotherapy has shown great success in the past five years as a first-line or second-line treatment for non-small cell lung cancer. Chemotherapy and radiotherapy have been used in combination with immunotherapy to enhance treatment outcomes. This study recruited 74 patients in their second-line treatment, with some receiving intravenous immunotherapy and others receiving intravenous cisplatin with immunotherapy. The findings suggest that both types of therapy can be effective under certain conditions.
Article
Respiratory System
Joao Pedro Steinhauser Motta, Jose Roberto Lapa e Silva, Amir Szklo, Ricardo E. Steffen
Summary: This study assesses the cost differences between EBUS-TBNA and mediastinoscopy for the mediastinal staging of non-small cell lung cancer. The study concludes that EBUS-TBNA is the least costly strategy in the Brazilian public health care system.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Oncology
Hans-Jonas Meyer, Benedikt Schnarkowski, Johanna Pappisch, Teresa Kerkhoff, Hubert Wirtz, Anne-Kathrin Hoehn, Sebastian Kraemer, Timm Denecke, Jakob Leonhardi, Armin Frille
Summary: The study demonstrates that CT texture analysis and Node-RADS can be used to differentiate benign from malignant mediastinal lymph nodes in patients with lung cancer, aiding in diagnosis.
Article
Engineering, Biomedical
Allan F. F. Alves, Sergio A. Souza, Raul L. Ruiz, Tarcisio A. Reis, Aglaia M. G. Ximenes, Erica N. Hasimoto, Rodrigo L. Pires, Jose Ricardo A. Miranda, Diana R. Pina
Summary: This study evaluated whether texture analysis combined with machine learning approaches could differentiate between malignant and benign lymph nodes. The results demonstrate that this method has the potential value in distinguishing malignant from benign lymph nodes, with low variability among different operators.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2021)
Article
Medicine, General & Internal
Ying-Yi Chen, Ying-Shian Chen, Tsai-Wang Huang
Summary: The study aimed to verify the importance and timing of EBUS TBNA in lung adenocarcinoma patients. The results showed that lung adenocarcinoma patients with recurrences who received EBUS TBNA had higher SUVmax and better survival. EBUS TBNA is a reliable tool for early diagnosis and obtaining adequate tissue specimens for further analysis in patients with recurrent lung adenocarcinoma.
Review
Cardiac & Cardiovascular Systems
Maribel Botana-Rial, Irene Lojo-Rodriguez, Virginia Leiro-Fernandez, Cristina Ramos-Hernandez, Almudena Gonzalez-Montaos, Luis Pazos-Area, Manuel Nunez-Delgado, Alberto Fernandez-Villar
Summary: CryoEBUS has shown higher diagnostic usefulness compared to EBUS-TBNA for mediastinal and hilar involvement, especially in cases of benign pathologies and other tumor types such as lymphomas. Samples obtained by cryoEBUS also allow for better histological subtyping of lymphoma and complete molecular characterization in cases of lung cancer.
RESPIRATORY MEDICINE
(2023)
