Review
Endocrinology & Metabolism
Huamin Zeng, Ying Zhang, Sikai Huang, Jinghua Wu, Wenrui Ren, Lingru Zhou, Leneng Huang, Yuyin Ye
Summary: Metformin combined with spironolactone therapy may be more effective in reducing BMI and serum androgen levels in PCOS patients. However, it does not have a significant effect on hirsutism score or gonadotropin hormone levels, and is not associated with an elevation in side-effects. When the treatment course is greater than 6 months, combination therapy can effectively reduce FBG and improve insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Paul Zarogoulidis, Haidong Huang, Zhenli Hu, Ning Wu, Jiannan Wang, Dimitris Petridis, Kosmas Tsakiridis, Dimitris Matthaios, Christoforos Kosmidis, Wolfgang Hohenforst-Schmidt, Christos Tolis, Ioannis Boukovinas, Nikolaos Courcoutsakis, George Nikolaidis, Chrysanthi Sardeli, Chong Bai, Chrysanthi Karapantzou
Summary: This retrospective study evaluated the cost-effectiveness of performing EBUS-TBNA before or after PET-CT in diagnosing lung lesions and undiagnosed lymphadenopathy. The results showed that conducting PET-CT prior to biopsy was more cost-effective in general, with different needle sizes offering varying levels of effectiveness for different types of lesions.
Article
Acoustics
Sheng-Ping Li, Zhen-Ming Zhang, Yu Bao, Ling-Xiao Zhou, Rui Zhao, Ji-Man Li, Ye-Han Zhou, Xi Chen, Shang-Zhi Hu, Wu-Song Liu
Summary: This study assessed the diagnostic and prognostic significance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for suspected intrathoracic metastasis after head and neck cancer (HNC) treatment. A retrospective analysis was conducted on 75 patients who underwent EBUS-TBNA for suspected intrathoracic metastases. The results showed that EBUS-TBNA is a safe and effective procedure for assessing suspected intrathoracic metastasis in HNC patients after treatment. Detection of intrathoracic metastasis through EBUS-TBNA is a significant independent prognostic factor for previously treated HNC patients.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Clinical Neurology
Zhen-Ye Ji, Yi-Qian Huang, Wen-Zhen He
Summary: Sodium valproate combined with topiramate is more effective than sodium valproate alone for treating refractory epilepsy, and it also shows better control over the frequency of absence seizures, atonic seizures, and tonic-clonic seizures.
FRONTIERS IN NEUROLOGY
(2022)
Review
Pediatrics
Karan Madan, Hariharan Iyer, Neha K. Madan, Saurabh Mittal, Pawan Tiwari, Vijay Hadda, Anant Mohan, Ravindra M. Pandey, Sushil K. Kabra, Randeep Guleria
Summary: EBUS-TBNA and EUS-B-FNA are safe and effective modalities for evaluating mediastinal lymphadenopathy in children, with high sampling adequacy and diagnostic yield. These techniques may be considered as first-line diagnostic modalities in pediatric patients.
PEDIATRIC PULMONOLOGY
(2021)
Article
Oncology
Yimin Wang, Hedong Han, Fang Zhang, Tangfeng Lv, Ping Zhan, Mingxiang Ye, Yong Song, Hongbing Liu
Summary: Through network meta-analyses, we found that chemo-ICI had significantly improved objective response rate (ORR) and progression-free survival (PFS) compared to immune checkpoint inhibitors alone (ICI) in non-small cell lung cancer patients with high PD-L1 expression. Subgroup analysis showed significant differences in ORR and PFS in non-squamous, PD-1 inhibitor, and first-line treatment cohorts, but not in squamous, PD-L1 inhibitor, and previously treated cohorts.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Eliano P. Navarese, Alexandra J. Lansky, Michael E. Farkouh, Klaudyna Grzelakowska, Marc P. Bonaca, Diana A. Gorog, Paolo Raggi, Malte Kelm, Brandon Yeo, Julia Uminska, Nick Curzen, Jacek Kubica, William Wijns, Dean J. Kereiakes
Summary: This study conducted a large-scale meta-analysis to compare the effect of coronary revascularization plus medical therapy (MT) versus MT alone on noncardiac mortality in patients with chronic coronary syndrome (CCS). The results showed that there was no significant difference in noncardiac mortality between the two treatment groups in long-term follow-up.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Oncology
Anthony V. Serritella, Niraj K. Shenoy
Summary: This meta-analysis found that the addition of ipilimumab to standard-dose nivolumab did not significantly improve overall survival and progression-free survival in advanced cancers other than melanoma. However, the combination therapy was associated with higher-grade treatment-related toxicities and discontinuations.
Review
Medicine, General & Internal
Dongrui Zhou, Liandi Xie, Xiaowei Shi, Fengzhi Liu, Shuang Wu, Shuangshuang Zhang, Ruijia Liu, Jingling Chang, Lingqun Zhu
Summary: The combination of Tanreqing injection (TRQI) and antibiotics is effective in treating pulmonary infection after intracerebral hemorrhage (ICH), improving clinical efficacy, shortening hospital stays, improving physiological indicators, and causing no adverse reactions. Further high-quality multicenter randomized controlled trials are needed to confirm the clinical efficacy of TRQI due to potential publication bias and low methodological quality in existing studies.
Review
Medicine, General & Internal
Jie Zhan, Xiaojing Wei, Chenyang Tao, Xiaoting Yan, Peiming Zhang, Rouhao Chen, Yu Dong, Hongxia Chen, Jianhua Liu, Liming Lu
Summary: This study evaluated the effect and safety of acupuncture combined with rehabilitation training (AR) versus rehabilitation training alone (RT) on post-stroke shoulder pain (PSSP). The results showed that AR was more effective than RT alone in reducing shoulder pain, improving upper limb motor function, ADL, and shoulder range of motion (ROM), without obvious adverse events.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Tommi Jarvinen, Juuso Paajanen, Ilkka Ilonen, Jari Rasanen
Summary: The treatment of malignant mesothelioma with high-temperature chemotherapeutic instillation seems beneficial, especially for epithelioid MPM patients. However, further high-quality studies are needed to validate these findings and standardize the approach.
Review
Medicine, General & Internal
Jiani Zhao, Chen Liao, Qian Wu, Li Wang, Fumou Deng, Wenxiong Zhang
Summary: The study compared the efficacy and safety of ropivacaine alone and in combination with dexmedetomidine for epidural anesthesia. It was found that the combination group had shorter onset times for sensory and motor blocks, as well as longer duration of anesthesia, but safety considerations are important.
Review
Medicine, General & Internal
Viktoriya L. Nikolova, Anthony J. Cleare, Allan H. Young, James M. Stone
Summary: This review evaluated the efficacy of probiotics for clinical depression, showing that probiotics are effective in reducing depressive symptoms when used adjunctively with antidepressants, but not as a stand-alone treatment. Potential mechanisms of action may involve increases in BDNF and decreases in CRP levels, but more evidence is needed to support this.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jian-Hong Yu, Zao-Zao Wang, Ying-Chong Fan, Mao-Xing Liu, Kai Xu, Nan Zhang, Zhen-Dan Yao, Hong Yang, Cheng-Hai Zhang, Jia-Di Xing, Ming Cui, Xiang-Qian Su
Summary: In comparing neoadjuvant chemotherapy followed by surgery (NACS) with surgery alone (SA) for locally advanced gastric cancer, no significant difference was found in overall survival, but the NACS group had a longer operation time, higher R0 resection rate, lower reoperation rate, and lower anastomotic leakage rate.
CHINESE MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Pattraporn Tajarernmuang, Linda Ofiara, Stephane Beaudoin, Hangjun Wang, Andrea Benedetti, Anne Gonzalez
Summary: The study indicates that PD-L1 results in EBUS-TBNA samples can guide ICI therapy, with treatment outcomes comparable to those of patients in whom PD-L1 expression was assessed in histological specimens.
Article
Critical Care Medicine
Joseph L. Simonson, Juliana A. Rosentsveyg, Noah G. Schwartz, Abhinav Agrawal, Seth Koenig, Gulrukh Z. Zaidi
Summary: This study investigated the target hemoglobin level for transfusion and optimal modality in treating acute chest syndrome. The results showed that transfusing to a hemoglobin level of >= 8 g/dL was associated with shorter hospital length of stay, and there was no difference in length of stay between patients who received exchange transfusion and those who did not.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Abhinav Agrawal
Summary: Interventional pulmonology is a rapidly evolving subspecialty of pulmonary medicine that offers advanced consultative and procedural services to patients with airway diseases, pleural diseases, as well as in the diagnosis and management of patients with thoracic malignancy. With continued high quality research and an increasing body of evidence, interventional bronchoscopy has enormous potential to provide both safe and effective options for patients with a variety of lung diseases.
AMERICAN JOURNAL OF THERAPEUTICS
(2021)
Article
Critical Care Medicine
Udit Chaddha, Abhinav Agrawal, David Feller-Kopman, Viren Kaul, Samira Shojaee, Fabien Maldonado, Mark K. Ferguson, Kevin G. Blyth, Horiana B. Grosu, John P. Corcoran, Ashutosh Sachdeva, Alex West, Eihab Bedawi, Adnan Majid, Ravindra M. Mehta, Erik Folch, Moishe Liberman, Momen M. Wahidi, Sidhu P. Gangadharan, Mark E. Roberts, Malcolm M. DeCamp, Najib M. Rahman
Summary: There is still ongoing debate on the optimal management of adult patients with empyema, especially in the use of intrapleural therapy. In response to the lack of comprehensive guidance in this area, an international expert group formulated a Position Paper with graded and ungraded recommendations based on a systematic evaluation of evidence and provider experience. This paper aims to bridge the knowledge gap and offer consensus-based recommendations for clinical decision making in this patient population.
LANCET RESPIRATORY MEDICINE
(2021)
Letter
Otorhinolaryngology
Abhinav Agrawal, Vinciya Pandian, Septimiu Murgu
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Letter
Respiratory System
Abhinav Agrawal, Laura Frye
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Abhinav Agrawal, Elliot Ho, Udit Chaddha, Baris Demirkol, Sivasubramanium Bhavani, Kyle Hogarth, Septimiu Murgu
Summary: This study reviewed consecutive cases in which robotic bronchoscopy (RB) was used for diagnosing lung lesions at the University of Chicago Medical Center from June 15, 2018, to December 15, 2019. The overall diagnostic accuracy was 77%, with radial endobronchial ultrasound (r-EBUS) views playing a significant role. Rating: 8/10.
ANNALS OF THORACIC SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Christian M. Lo Cascio, Viren Kaul, Sahajal Dhooria, Abhinav Agrawal, Udit Chaddha
Summary: Tuberculous pleural effusion is a common presentation of extrapulmonary tuberculosis, posing diagnostic challenges. In addition to biomarkers and PCR methods, pleural biopsies are important for confirming the diagnosis.
RESPIRATORY MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Abhinav Agrawal, Brandon J. Baird, Maria Lucia L. Madariaga, Elizabeth A. Blair, Septimiu Murgu
Summary: Accurate diagnosis and appropriate treatment of airway strictures are crucial, and collaborative multidisciplinary teams can better manage patients, avoiding unnecessary surgeries and worsening disease course.
RESPIRATORY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gaurav Mohan, Poorva Bhide, Abhinav Agrawal, Viren Kaul, Udit Chaddha
Summary: This article discusses a practical approach to correctly classify effusions that may be pseudoexudates. Common causes of pseudoexudates include diuretic therapy, traumatic pleural taps, and coronary artery bypass grafting. The suggested diagnostic algorithm involves using serum-pleural effusion albumin gradient (SPAG) > 1.2 g/dL and serum-pleural effusion protein gradient (SPPG) > 3.1 g/dL.
RESPIRATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bertin D. Salguero, Abhinav Agrawal, Christian M. Lo Cascio, Matsuo So, Udit Chaddha
Summary: This study reviewed the outcomes of airway stent removal at Mount Sinai Hospital from 2018 to 2022. The results show that, with modern stent technology and advancements in cancer treatment and surveillance bronchoscopies, the removal of airway stents can be safely performed.
RESPIRATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Rutuja R. Sikachi, Udit Chaddha, Abhinav Agrawal
Summary: Pleuroscopy, also known as medical thoracoscopy, is a commonly used procedure in interventional pulmonology. It is mainly used for pleural biopsies and other interventions in patients with undiagnosed pleural effusions and empyema. The procedure can be done under local anesthesia with moderate sedation or under monitored anesthesia care. This article discusses the technical aspects of pleuroscopy and the peri-operative considerations for proceduralists and anesthesiologists.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Abhinav Agrawal, Udit Chaddha, Baris Demirkol, Septimiu Murgu
JOURNAL OF THORACIC DISEASE
(2021)
Letter
Respiratory System
Elliot Ho, Abhinav Agrawal, Douglas Kyle Hogarth, Septimiu Murgu
JOURNAL OF THORACIC DISEASE
(2021)
Article
Respiratory System
Udit Chaddha, Abhinav Agrawal, Sivasubramanium V. Bhavani, Kimberly Sivertsen, D. Jessica Donington, Mark K. Ferguson, Septimiu Murgu
Summary: In patients with MPE, thoracic ultrasound at the time of IPC removal accurately predicts the success of pleurodesis, reducing the risk of pleural effusion recurrence or the need for pleural intervention for at least 3 months post-IPC removal.
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)
