N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges

Therapeutic Potential of Selectively Targeting the α2C-Adrenoceptor in Cognition, Depression, and Schizophrenia—New Developments and Future Perspective

(2017) Madeleine Monique Uys et al.   Frontiers in Psychiatry

A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis

(2016) Justin Davis et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol

(2016) Madeleine Uys et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neurodevelopmental Animal Models Reveal the Convergent Role of Neurotransmitter Systems, Inflammation, and Oxidative Stress as Biomarkers of Schizophrenia: Implications for Novel Drug Development

(2015) M. Möller et al.   ACS Chemical Neuroscience

Anxiety in Patients with Schizophrenia: Epidemiology and Management

(2015) Henk Temmingh et al.   CNS DRUGS

A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates

(2015) Sarel Brand et al.   Current Neuropharmacology

Developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the PFC and hippocampus of offspring at weaning

(2015) Mary Gemmel et al.   DEVELOPMENTAL PSYCHOBIOLOGY

The long-term effects of methamphetamine exposure during pre-adolescence on depressive-like behaviour in a genetic animal model of depression

(2015) Moné Mouton et al.   METABOLIC BRAIN DISEASE

Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood

(2015) A.M. Depino   NEUROSCIENCE

Fetal programming of schizophrenia: Select mechanisms

(2015) Monojit Debnath et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Prenatal LPS-exposure – a neurodevelopmental rat model of schizophrenia – differentially affects cognitive functions, myelination and parvalbumin expression in male and female offspring

(2015) Lena Wischhof et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and Cognitive Problems in Adults with and without Methamphetamine Dependence: An Exploratory Protein Array Study

(2015) Marilyn Huckans et al.   Frontiers in Psychiatry

Neuroprogression in schizophrenia: Pathways underpinning clinical staging and therapeutic corollaries

(2014) Justin Davis et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Additive effects of maternal iron deficiency and prenatal immune activation on adult behaviors in rat offspring

(2014) Louise Harvey et al.   BRAIN BEHAVIOR AND IMMUNITY

The different effects of LPS and poly I:C prenatal immune challenges on the behavior, development and inflammatory responses in pregnant mice and their offspring

(2014) Dany Arsenault et al.   BRAIN BEHAVIOR AND IMMUNITY

Schizophrenia: from dopaminergic to glutamatergic interventions

(2014) Marc Laruelle   CURRENT OPINION IN PHARMACOLOGY

The Novel Object Recognition Test in Rodents in Relation to Cognitive Impairment in Schizophrenia

(2014) Lakshmi Rajagopal et al.   CURRENT PHARMACEUTICAL DESIGN

Late-Life Effects of Chronic Methamphetamine Exposure during Puberty on Behaviour and Corticostriatal Mono-Amines in Social Isolation-Reared Rats

(2014) Laetitia Strauss et al.   DEVELOPMENTAL NEUROSCIENCE

Time to relapse following treatment for methamphetamine use: A long-term perspective on patterns and predictors

(2014) Mary-Lynn Brecht et al.   DRUG AND ALCOHOL DEPENDENCE

Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood

(2014) Anne-Laure Dinel et al.   Journal of Neuroinflammation

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats

(2014) Michèle Crumeyrolle-Arias et al.   PSYCHONEUROENDOCRINOLOGY

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of ‘schizophrenia-like’ behaviour in the rat

(2014) Philip LR Gaskin et al.   PSYCHOPHARMACOLOGY

N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats

(2013) Marisa Möller et al.   METABOLIC BRAIN DISEASE

A “double hit” murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus

(2013) Javier Gilabert-Juan et al.   NEUROBIOLOGY OF DISEASE

Effect of Maternal Lipopolysaccharide Administration on the Development of Dopaminergic Receptors and Transporter in the Rat Offspring

(2013) Moogeh Baharnoori et al.   PLoS One

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine

(2012) Marisa Möller et al.   BRAIN BEHAVIOR AND IMMUNITY

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings

(2012) William J. Panenka et al.   DRUG AND ALCOHOL DEPENDENCE

Maternal N-acetyl-cysteine (NAC) protects the rat fetal brain from inflammatory cytokine responses to lipopolysaccharide (LPS)

(2012) Ron Beloosesky et al.   Journal of Maternal-Fetal & Neonatal Medicine

Cognitive impairment is related to oxidative stress and chemokine levels in first psychotic episodes

(2012) Mónica Martínez-Cengotitabengoa et al.   SCHIZOPHRENIA RESEARCH

Methamphetamine-Associated Psychosis

(2011) Kathleen M. Grant et al.   Journal of Neuroimmune Pharmacology

A stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy

(2011) Louise Harvey et al.   NEUROPHARMACOLOGY

Discrete Forebrain Neuronal Networks Supporting Noradrenergic Regulation of Sensorimotor Gating

(2011) Karen M Alsene et al.   NEUROPSYCHOPHARMACOLOGY

Prenatal lipopolysaccharide treatment enhances MK-801-induced psychotomimetic effects in rats

(2011) A. Basta-Kaim et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Developmental neuroinflammation and schizophrenia

(2011) Urs Meyer   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

(2010) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Amphetamine toxicities

(2010) Bryan K. Yamamoto et al.   Annals of the New York Academy of Sciences

Prenatal inflammation impairs adult neurogenesis and memory related behavior through persistent hippocampal TGFβ1 downregulation

(2010) Mariana Graciarena et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of prenatal infection on brain development and behavior: A review of findings from animal models

(2010) Patricia Boksa   BRAIN BEHAVIOR AND IMMUNITY

Prenatal LPS increases Inflammation in the Substantia Nigra of Gdnf Heterozygous Mice

(2010) Ann-Charlotte Granholm et al.   BRAIN PATHOLOGY

Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin

(2010) Joana Gonçalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration

(2010) Marisa Möller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Oxidative stress in schizophrenia: An integrated approach

(2010) Byron K.Y. Bitanihirwe et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Methamphetamine Causes Persistent Immune Dysregulation: A Cross-Species, Translational Report

(2010) Jennifer M. Loftis et al.   NEUROTOXICITY RESEARCH

Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice

(2010) Curtis E. Grace et al.   NEUROTOXICOLOGY AND TERATOLOGY

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

A meta-analysis of oxidative stress markers in schizophrenia

(2010) Ming Zhang et al.   Science China-Life Sciences

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-d-aspartate and D1 receptor binding in rats

(2009) C. Toua et al.   NEUROSCIENCE

Schizophrenia, “just the facts” 4. Clinical features and conceptualization

(2009) Rajiv Tandon et al.   SCHIZOPHRENIA RESEARCH

Antidepressant-like effects of N-acetyl-L-cysteine in rats

(2008) Frederico F. Ferreira et al.   BEHAVIOURAL PHARMACOLOGY

N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial

(2008) Michael Berk et al.   BIOLOGICAL PSYCHIATRY

LateN-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation

(2008) Fabien Lanté et al.   HIPPOCAMPUS

The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress

(2008) Jorge Limón-Pacheco et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats

(2008) J. L. Rogers et al.   PSYCHOPHARMACOLOGY

A Review of the Fetal Brain Cytokine Imbalance Hypothesis of Schizophrenia

(2008) U. Meyer et al.   SCHIZOPHRENIA BULLETIN