Regulation of cannabinoid CB2 receptor constitutive activity in vivo: repeated treatments with inverse agonists reverse the acute activation of JNK and associated apoptotic signaling in mouse brain
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Regulation of cannabinoid CB2 receptor constitutive activity in vivo: repeated treatments with inverse agonists reverse the acute activation of JNK and associated apoptotic signaling in mouse brain
Authors
Keywords
Cannabinoid CB<sub>2</sub> receptors, Constitutive activity, Inverse agonists, AM630, JTE907, Raloxifene
Journal
PSYCHOPHARMACOLOGY
Volume 234, Issue 6, Pages 925-941
Publisher
Springer Nature
Online
2017-01-27
DOI
10.1007/s00213-017-4537-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats
- (2016) Cristiane R. de Carvalho et al. EPILEPSY RESEARCH
- Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus
- (2016) Yong Li et al. HIPPOCAMPUS
- The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons
- (2016) Isa Guha et al. NEUROBIOLOGY OF AGING
- Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus
- (2016) A. Vanessa Stempel et al. NEURON
- CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory
- (2016) Yong Li et al. NEURAL PLASTICITY
- Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders
- (2016) Gemma Navarro et al. Frontiers in Neuroscience
- Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex
- (2016) Rebeca Diez-Alarcia et al. Frontiers in Pharmacology
- The neuroplastic index p-FADD/FADD and phosphoprotein PEA-15, interacting at GABAA receptor, are upregulated in brain cortex during midazolam-induced hypnosis in mice
- (2015) María Álvaro-Bartolomé et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus
- (2015) Y. Li et al. NEUROSCIENCE
- Identification of CB2 receptors in human nigral neurons that degenerate in Parkinson’s disease
- (2015) María Concepción García et al. NEUROSCIENCE LETTERS
- Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?
- (2015) Nick J. Spencer Frontiers in Cellular Neuroscience
- P.1.g.040 Effects of CB2 receptor inverse agonists on JNK activation and pro-apoptotic Bax in mouse brain
- (2014) G. Salort et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB–Bcl-2 pathway after subarachnoid hemorrhage in rats
- (2014) Mutsumi Fujii et al. EXPERIMENTAL NEUROLOGY
- Cannabinoid CB2receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice
- (2014) Hai-Ying Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- What we know and do not know about the cannabinoid receptor 2 (CB2)
- (2014) Anna Maria Malfitano et al. SEMINARS IN IMMUNOLOGY
- The vital role of constitutive GPCR activity in the mesolimbic dopamine system
- (2014) F J Meye et al. Translational Psychiatry
- Identification of raloxifene as a novel CB2 inverse agonist
- (2013) Pritesh Kumar et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors
- (2013) Pietro Marini et al. BRITISH JOURNAL OF PHARMACOLOGY
- Changes in CB1and CB2receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxias
- (2013) Carmen Rodríguez-Cueto et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabinoid Receptor 2 Suppresses Leukocyte Inflammatory Migration by Modulating the JNK/c-Jun/Alox5 Pathway
- (2013) Yi-Jie Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors
- (2013) María S. García-Gutiérrez et al. NEUROPHARMACOLOGY
- Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
- (2013) M. Álvaro-Bartolomé et al. NEUROSCIENCE
- The Endocannabinoid System and the Brain
- (2012) Raphael Mechoulam et al. Annual Review of Psychology
- The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats
- (2012) Przemysław Adamczyk et al. BRAIN RESEARCH
- Cannabinoid Receptors CB1and CB2Form Functional Heteromers in Brain
- (2012) Lucía Callén et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endocannabinoid tone versus constitutive activity of cannabinoid receptors
- (2011) Allyn C. Howlett et al. BRITISH JOURNAL OF PHARMACOLOGY
- AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor
- (2011) Daniele Bolognini et al. BRITISH JOURNAL OF PHARMACOLOGY
- Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABAA receptors
- (2011) María S García-Gutiérrez et al. BRITISH JOURNAL OF PHARMACOLOGY
- CB2Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling
- (2011) Javier Palazuelos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity
- (2011) Emmanuel S Onaivi et al. JOURNAL OF PSYCHOPHARMACOLOGY
- CB2: Therapeutic target-in-waiting
- (2011) Brady K. Atwood et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Antibody validation
- (2010) Jennifer Bordeaux et al. BIOTECHNIQUES
- Regulation of Fas receptor/Fas-asssociated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain
- (2010) M Álvaro-Bartolomé et al. BRITISH JOURNAL OF PHARMACOLOGY
- Depression-resistant endophenotype in mice overexpressing cannabinoid CB2 receptors
- (2010) MS García-Gutiérrez et al. BRITISH JOURNAL OF PHARMACOLOGY
- Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of α2-adrenoceptors and extracellular signal-regulated kinases
- (2010) Alfredo Ramos-Miguel et al. JOURNAL OF PSYCHOPHARMACOLOGY
- International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
- (2010) R. G. Pertwee et al. PHARMACOLOGICAL REVIEWS
- Brain Cannabinoid CB2 Receptor in Schizophrenia
- (2009) Hiroki Ishiguro et al. BIOLOGICAL PSYCHIATRY
- Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242
- (2009) I Mancini et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effect of the CB1 receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices
- (2009) Aitziber Mendiguren et al. BRITISH JOURNAL OF PHARMACOLOGY
- The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: Role of PEA-15 as a FADD-ERK binding partner in striatal plasticity
- (2009) Alfredo Ramos-Miguel et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142
- (2009) K.S. Sink et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Anandamide enhances IL-10 production in activated microglia by targeting CB2receptors: Roles of ERK1/2, JNK, and NF-κB
- (2009) Fernando Correa et al. GLIA
- Selective CB2 Receptor Agonism Protects Central Neurons from Remote Axotomy-Induced Apoptosis through the PI3K/Akt Pathway
- (2009) M. T. Viscomi et al. JOURNAL OF NEUROSCIENCE
- Functional CB2 type cannabinoid receptors at CNS synapses
- (2009) Nicola H. Morgan et al. NEUROPHARMACOLOGY
- Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: Relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity
- (2009) A. Ramos-Miguel et al. NEUROSCIENCE
- All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death
- (2008) Benny Björkblom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: Functional interactions with casein kinase Iα, Gαi proteins, and ERK1/2 signaling
- (2008) M. Julia García-Fuster et al. NEUROPHARMACOLOGY
- Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers
- (2008) M.J. García-Fuster et al. NEUROSCIENCE
- JNK signaling in apoptosis
- (2008) D N Dhanasekaran et al. ONCOGENE
- Biology and therapeutic potential of cannabinoid CB2receptor inverse agonists
- (2007) C A Lunn et al. BRITISH JOURNAL OF PHARMACOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started