Regulation of cannabinoid CB2 receptor constitutive activity in vivo: repeated treatments with inverse agonists reverse the acute activation of JNK and associated apoptotic signaling in mouse brain

The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats

(2016) Cristiane R. de Carvalho et al.   EPILEPSY RESEARCH

Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus

(2016) Yong Li et al.   HIPPOCAMPUS

The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons

(2016) Isa Guha et al.   NEUROBIOLOGY OF AGING

Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus

(2016) A. Vanessa Stempel et al.   NEURON

CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory

(2016) Yong Li et al.   NEURAL PLASTICITY

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

(2016) Gemma Navarro et al.   Frontiers in Neuroscience

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex

(2016) Rebeca Diez-Alarcia et al.   Frontiers in Pharmacology

The neuroplastic index p-FADD/FADD and phosphoprotein PEA-15, interacting at GABAA receptor, are upregulated in brain cortex during midazolam-induced hypnosis in mice

(2015) María Álvaro-Bartolomé et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus

(2015) Y. Li et al.   NEUROSCIENCE

Identification of CB2 receptors in human nigral neurons that degenerate in Parkinson’s disease

(2015) María Concepción García et al.   NEUROSCIENCE LETTERS

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?

(2015) Nick J. Spencer   Frontiers in Cellular Neuroscience

P.1.g.040 Effects of CB2 receptor inverse agonists on JNK activation and pro-apoptotic Bax in mouse brain

(2014) G. Salort et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB–Bcl-2 pathway after subarachnoid hemorrhage in rats

(2014) Mutsumi Fujii et al.   EXPERIMENTAL NEUROLOGY

Cannabinoid CB2receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

(2014) Hai-Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What we know and do not know about the cannabinoid receptor 2 (CB2)

(2014) Anna Maria Malfitano et al.   SEMINARS IN IMMUNOLOGY

The vital role of constitutive GPCR activity in the mesolimbic dopamine system

(2014) F J Meye et al.   Translational Psychiatry

Identification of raloxifene as a novel CB2 inverse agonist

(2013) Pritesh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors

(2013) Pietro Marini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Changes in CB1and CB2receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxias

(2013) Carmen Rodríguez-Cueto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid Receptor 2 Suppresses Leukocyte Inflammatory Migration by Modulating the JNK/c-Jun/Alox5 Pathway

(2013) Yi-Jie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors

(2013) María S. García-Gutiérrez et al.   NEUROPHARMACOLOGY

Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents

(2013) M. Álvaro-Bartolomé et al.   NEUROSCIENCE

The Endocannabinoid System and the Brain

(2012) Raphael Mechoulam et al.   Annual Review of Psychology

The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats

(2012) Przemysław Adamczyk et al.   BRAIN RESEARCH

Cannabinoid Receptors CB1and CB2Form Functional Heteromers in Brain

(2012) Lucía Callén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocannabinoid tone versus constitutive activity of cannabinoid receptors

(2011) Allyn C. Howlett et al.   BRITISH JOURNAL OF PHARMACOLOGY

AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor

(2011) Daniele Bolognini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABAA receptors

(2011) María S García-Gutiérrez et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB2Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling

(2011) Javier Palazuelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity

(2011) Emmanuel S Onaivi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

CB2: Therapeutic target-in-waiting

(2011) Brady K. Atwood et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antibody validation

(2010) Jennifer Bordeaux et al.   BIOTECHNIQUES

Regulation of Fas receptor/Fas-asssociated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain

(2010) M Álvaro-Bartolomé et al.   BRITISH JOURNAL OF PHARMACOLOGY

Depression-resistant endophenotype in mice overexpressing cannabinoid CB2 receptors

(2010) MS García-Gutiérrez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of α2-adrenoceptors and extracellular signal-regulated kinases

(2010) Alfredo Ramos-Miguel et al.   JOURNAL OF PSYCHOPHARMACOLOGY

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Brain Cannabinoid CB2 Receptor in Schizophrenia

(2009) Hiroki Ishiguro et al.   BIOLOGICAL PSYCHIATRY

Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242

(2009) I Mancini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of the CB1 receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices

(2009) Aitziber Mendiguren et al.   BRITISH JOURNAL OF PHARMACOLOGY

The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: Role of PEA-15 as a FADD-ERK binding partner in striatal plasticity

(2009) Alfredo Ramos-Miguel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142

(2009) K.S. Sink et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anandamide enhances IL-10 production in activated microglia by targeting CB2receptors: Roles of ERK1/2, JNK, and NF-κB

(2009) Fernando Correa et al.   GLIA

Selective CB2 Receptor Agonism Protects Central Neurons from Remote Axotomy-Induced Apoptosis through the PI3K/Akt Pathway

(2009) M. T. Viscomi et al.   JOURNAL OF NEUROSCIENCE

Functional CB2 type cannabinoid receptors at CNS synapses

(2009) Nicola H. Morgan et al.   NEUROPHARMACOLOGY

Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: Relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity

(2009) A. Ramos-Miguel et al.   NEUROSCIENCE

All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death

(2008) Benny Björkblom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: Functional interactions with casein kinase Iα, Gαi proteins, and ERK1/2 signaling

(2008) M. Julia García-Fuster et al.   NEUROPHARMACOLOGY

Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers

(2008) M.J. García-Fuster et al.   NEUROSCIENCE

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Biology and therapeutic potential of cannabinoid CB2receptor inverse agonists

(2007) C A Lunn et al.   BRITISH JOURNAL OF PHARMACOLOGY