Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia

Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium

(2017) S Stern et al.   MOLECULAR PSYCHIATRY

Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity

(2016) S. Sarkar et al.   BRAIN RESEARCH

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Neural Subtype Specification from Human Pluripotent Stem Cells

(2016) Yunlong Tao et al.   Cell Stem Cell

Therapeutic Mechanisms of Lithium in Bipolar Disorder: Recent Advances and Current Understanding

(2016) Gin S. Malhi et al.   CNS DRUGS

Simultaneous quantification of neuroactive dopamine serotonin and kynurenine pathway metabolites in gender-specific youth urine by ultra performance liquid chromatography tandem high resolution mass spectrometry

(2016) Haihua Lu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models

(2016) J Xu et al.   MOLECULAR PSYCHIATRY

Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain

(2016) Jinju Han et al.   NEURON

Lithium in Bipolar Disorder: Optimizing Therapy Using Prolonged-Release Formulations

(2016) Paolo Girardi et al.   Drugs in research & development

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

(2016) Aaron Topol et al.   Cell Reports

Analysis of induced pluripotent stem cells carrying 22q11.2 deletion

(2016) M Toyoshima et al.   Translational Psychiatry

Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses

(2015) Motoko Maekawa et al.   BIOLOGICAL PSYCHIATRY

Activin A directs striatal projection neuron differentiation of human pluripotent stem cells

(2015) C. Arber et al.   DEVELOPMENT

Psychostimulants affect dopamine transmission through both dopamine transporter-dependent and independent mechanisms

(2015) Ike dela Peña et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

(2015) Rosalind Norkett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder

(2015) S Bavamian et al.   MOLECULAR PSYCHIATRY

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

(2015) J M Madison et al.   MOLECULAR PSYCHIATRY

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Spatiotemporal 16p11.2 Protein Network Implicates Cortical Late Mid-Fetal Brain Development and KCTD13-Cul3-RhoA Pathway in Psychiatric Diseases

(2015) Guan Ning Lin et al.   NEURON

MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del

(2015) Dejian Zhao et al.   PLoS One

Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree

(2015) Kwi Hye Kim et al.   PLoS One

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

(2014) Ki-Jun Yoon et al.   Cell Stem Cell

MicroRNA and epilepsy

(2014) David C. Henshall   CURRENT OPINION IN NEUROLOGY

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

(2014) K Brennand et al.   MOLECULAR PSYCHIATRY

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Mobile DNA elements in the generation of diversity and complexity in the brain

(2014) Jennifer A. Erwin et al.   NATURE REVIEWS NEUROSCIENCE

Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders

(2014) Kazue Hashimoto-Torii et al.   NEURON

Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia

(2014) Miki Bundo et al.   NEURON

Efficient Specification of Interneurons from Human Pluripotent Stem Cells by Dorsoventral and Rostrocaudal Modulation

(2014) Tae-Gon Kim et al.   STEM CELLS

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

(2014) H M Chen et al.   Translational Psychiatry

Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells

(2014) Diana Xuan Yu et al.   Stem Cell Reports

Lurasidone and Bipolar Disorder

(2013) R.H. Belmaker   AMERICAN JOURNAL OF PSYCHIATRY

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

(2013) Suleyman Gulsuner et al.   CELL

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

(2013) Asif M. Maroof et al.   Cell Stem Cell

Shining a light on CNTNAP2: complex functions to complex disorders

(2013) Pedro Rodenas-Cuadrado et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

(2013) Fumiaki Ogawa et al.   HUMAN MOLECULAR GENETICS

The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment

(2013) Ana C. Andreazza et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Genetics of bipolar disorder

(2013) Nick Craddock et al.   LANCET

High rate of disease-related copy number variations in childhood onset schizophrenia

(2013) K Ahn et al.   MOLECULAR PSYCHIATRY

Specificity of psychosis, mania and major depression in a contemporary family study

(2013) C L Vandeleur et al.   MOLECULAR PSYCHIATRY

Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients

(2013) O Robicsek et al.   MOLECULAR PSYCHIATRY

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

(2013) Yan Liu et al.   Nature Protocols

Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ

(2013) Matthew D. Shirley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Robust Formation and Maintenance of Continuous Stratified Cortical Neuroepithelium by Laminin-Containing Matrix in Mouse ES Cell Culture

(2013) Makoto Nasu et al.   PLoS One

Use of “MGE Enhancers” for Labeling and Selection of Embryonic Stem Cell-Derived Medial Ganglionic Eminence (MGE) Progenitors and Neurons

(2013) Ying-Jiun J. Chen et al.   PLoS One

Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures

(2013) Myrrhe van Spronsen et al.   PLoS One

Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia

(2013) Michael J. Berridge   Prion

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment Use and Costs Among Privately Insured Youths With Diagnoses of Bipolar Disorder

(2013) Stacie B. Dusetzina et al.   PSYCHIATRIC SERVICES

Maturation of the Human Dorsolateral Prefrontal Cortex Coincides With a Dynamic Shift in MicroRNA Expression

(2013) Natalie J. Beveridge et al.   SCHIZOPHRENIA BULLETIN

Subset specification of central serotonergic neurons

(2013) Marten P. Smidt et al.   Frontiers in Cellular Neuroscience

Drosophila cyfip Regulates Synaptic Development and Endocytosis by Suppressing Filamentous Actin Assembly

(2013) Lu Zhao et al.   PLoS Genetics

Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

(2013) Tewarit Sarachana et al.   Molecular Autism

The FMRP regulon: from targets to disease convergence

(2013) Esperanza Fernández et al.   Frontiers in Neuroscience

Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders

(2012) Jonathan T. Ting et al.   Annual Review of Neuroscience

The Role of Organizers in Patterning the Nervous System

(2012) Clemens Kiecker et al.   Annual Review of Neuroscience

Regional and Cell-Type-Specific Effects of DAMGO on Striatal D1 and D2 Dopamine Receptor-Expressing Medium-Sized Spiny Neurons

(2012) Yao-Ying Ma et al.   ASN Neuro

Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains

(2012) Antonia Alonso et al.   Brain Structure & Function

Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGFβ Suppression

(2012) Michael Ginsberg et al.   CELL

Dorsal-ventral patterning of the neural tube: A tale of three signals

(2012) Gwenvael Le Dréau et al.   Developmental Neurobiology

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis

(2012) Ruth Simon et al.   EMBO JOURNAL

A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide

(2012) Paul R. Matthews et al.   JOURNAL OF AFFECTIVE DISORDERS

Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case–control sample

(2012) E K Green et al.   MOLECULAR PSYCHIATRY

Association at SYNE1 in both bipolar disorder and recurrent major depression

(2012) E K Green et al.   MOLECULAR PSYCHIATRY

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

(2012) M Ayalew et al.   MOLECULAR PSYCHIATRY

Serotonergic transcriptional networks and potential importance to mental health

(2012) Evan S Deneris et al.   NATURE NEUROSCIENCE

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations

(2012) Annapurna Poduri et al.   NEURON

The involvement of Reelin in neurodevelopmental disorders

(2012) Timothy D. Folsom et al.   NEUROPHARMACOLOGY

MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc

(2012) Karin Wibrand et al.   PLoS One

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients

(2012) Harold W. Koenigsberg et al.   PSYCHIATRY RESEARCH

Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells

(2012) Jiajie Xi et al.   STEM CELLS

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder

(2011) Sven Cichon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Predictive animal models of mania: hits, misses and future directions

(2011) Jared W Young et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived from a Schizophrenic Patient

(2011) Bruna Da Silveira Paulsen et al.   CELL TRANSPLANTATION

Meta-Analysis of Epidemiologic Studies of Pediatric Bipolar Disorder

(2011) Anna R. Van Meter et al.   JOURNAL OF CLINICAL PSYCHIATRY

Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells

(2011) Erika Pedrosa et al.   JOURNAL OF NEUROGENETICS

Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex

(2011) F. H. F. Lee et al.   JOURNAL OF NEUROSCIENCE

Generation of Induced Pluripotent Stem Cells from Urine

(2011) T. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Co-ordinated action of DISC1, PDE4B and GSK3β in modulation of cAMP signalling

(2011) B C Carlyle et al.   MOLECULAR PSYCHIATRY

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

(2011) Koko Ishizuka et al.   NATURE

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

The NMDA receptor co-agonists, d-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex

(2011) Darrick T. Balu et al.   NEUROBIOLOGY OF DISEASE

DISC1-binding proteins in neural development, signalling and schizophrenia

(2011) Nicholas J. Bradshaw et al.   NEUROPHARMACOLOGY

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

(2011) O. Karalay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The construction of transgenic and gene knockout/knockin mouse models of human disease

(2011) Alfred Doyle et al.   TRANSGENIC RESEARCH

DISC1 at 10: connecting psychiatric genetics and neuroscience

(2011) David J. Porteous et al.   TRENDS IN MOLECULAR MEDICINE

The contribution of GABAergic dysfunction to neurodevelopmental disorders

(2011) Kartik Ramamoorthi et al.   TRENDS IN MOLECULAR MEDICINE

Confirmed rare copy number variants implicate novel genes in schizophrenia

(2010) Gloria W.C. Tam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Upregulation of Dicer and MicroRNA Expression in the Dorsolateral Prefrontal Cortex Brodmann Area 46 in Schizophrenia

(2010) Danielle M. Santarelli et al.   BIOLOGICAL PSYCHIATRY

Altered MicroRNA Expression Profiles in Postmortem Brain Samples from Individuals with Schizophrenia and Bipolar Disorder

(2010) Michael P. Moreau et al.   BIOLOGICAL PSYCHIATRY

Endoxifen is a new potent inhibitor of PKC: A potential therapeutic agent for bipolar disorder

(2010) Shoukath M. Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?

(2010) Joshua T. Kantrowitz et al.   BRAIN RESEARCH BULLETIN

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume

(2010) K. I. Erickson et al.   JOURNAL OF NEUROSCIENCE

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

(2010) Q Wang et al.   MOLECULAR PSYCHIATRY

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

(2010) Francis J McMahon et al.   NATURE GENETICS

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

(2010) F. Bedogni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of depression and anxiety: What do they tell us about human condition?

(2010) I.D. Neumann et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders

(2010) Albert H. Kim et al.   SCHIZOPHRENIA RESEARCH

Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia

(2009) Jun-Feng Wang et al.   BIPOLAR DISORDERS

Generation of induced pluripotent stem cells from human blood

(2009) Y.-H. Loh et al.   BLOOD

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

The Management of Individuals with Bipolar Disorder

(2009) Gin S. Malhi et al.   DRUGS

Support for the involvement of large copy number variants in the pathogenesis of schizophrenia

(2009) George Kirov et al.   HUMAN MOLECULAR GENETICS

Bipolar disorder: from genes to behavior pathways

(2009) Keri Martinowich et al.   JOURNAL OF CLINICAL INVESTIGATION

Schizophrenia is associated with an increase in cortical microRNA biogenesis

(2009) N J Beveridge et al.   MOLECULAR PSYCHIATRY

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

(2009) Tomoko Kuwabara et al.   NATURE NEUROSCIENCE

Neurod1 is essential for the survival and maturation of adult-born neurons

(2009) Zhengliang Gao et al.   NATURE NEUROSCIENCE

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

(2009) P. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

(2009) E. P. Papapetrou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Wnt Signaling Maintains Neural Progenitor Cell Potency

(2009) Eric M. Wexler et al.   STEM CELLS

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

An intrinsic mechanism of corticogenesis from embryonic stem cells

(2008) Nicolas Gaspard et al.   NATURE

Heterogeneous dysregulation of microRNAs across the autism spectrum

(2008) Kawther Abu-Elneel et al.   NEUROGENETICS

Satb2 Is a Postmitotic Determinant for Upper-Layer Neuron Specification in the Neocortex

(2008) Olga Britanova et al.   NEURON

Satb2 Regulates Callosal Projection Neuron Identity in the Developing Cerebral Cortex

(2008) Elizabeth A. Alcamo et al.   NEURON

Evidence for Selective microRNAs and Their Effectors as Common Long-Term Targets for the Actions of Mood Stabilizers

(2008) Rulun Zhou et al.   NEUROPSYCHOPHARMACOLOGY

Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: The therapeutic potentials for schizophrenia

(2008) Charles R. Yang et al.   PHARMACOLOGY & THERAPEUTICS

Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate

(2008) V. S. Mangale et al.   SCIENCE

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator

(2008) Noriko Osumi et al.   STEM CELLS

Schizophrenia and 22q11.2 deletion syndrome

(2008) Anne S. Bassett et al.   Current Psychiatry Reports